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Thymol nanoemulsion and preparation method thereof

A technology of thymol and nanoemulsion, which is applied in the direction of emulsion transportation, digestive system, active ingredients of hydroxyl compounds, etc., can solve the problems of restriction, lack of solubility and stability of thymol, and achieve good stability

Inactive Publication Date: 2018-01-09
CHENGDU LINGXI SHANGPIN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can promote the movement of tracheal cilia, which is beneficial to the secretion of tracheal mucus. It is easy to eliminate phlegm and has a bactericidal effect. However, the solubility and stability of thymol are lacking, and it is greatly restricted in clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] Thymol nanoemulsion of this example, by mass fraction: w (thymol) = 8%, w (EL-40) = 32%, w (1,2-propylene glycol) = 3%, w (distilled water) = 57%.

[0025] Its preparation method comprises the following steps:

[0026] (1) Add EL-40 and thymol into the four-necked flask, and stir to make it evenly mixed;

[0027] (2) Fix the four-necked flask under the condition of water bath, keep the water temperature at 40~60℃, after the raw materials are fully melted, start the stirrer, and the stirring speed is 150~200rpm;

[0028] (3) After the temperature of the raw materials in the four-neck flask reaches 40~60°C, stop stirring, add oil and 1,2-propanediol, and continue stirring for 30 minutes;

[0029] (4) Stop stirring, add hot distilled water at 40~60°C dropwise with a rubber dropper, after 3~8h of dropping, keep warm at 40~60°C for 1h;

[0030] (5) Turn off the water bath heating, cool down to room temperature, add fungicide, and continue stirring for 30 minutes;

[0031...

Embodiment 2

[0035] In order to better realize the preparation of nanoemulsions in this example, it is further limited that the stirrers used in the preparation process are all magnetic stirrers. Other parts of this embodiment are the same as those of the foregoing embodiment, and will not be repeated here.

Embodiment 3

[0037] In order to better realize the preparation of nanoemulsions in this embodiment, it is further limited that in the step (4), the distilled water is dripped with a glue-tipped dropper. Other parts of this embodiment are the same as those of the foregoing embodiment, and will not be repeated here.

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PUM

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Abstract

The invention discloses thymol nanoemulsion and a preparation method thereof. The thymol nanoemulsion is mainly prepared from the following components in parts by weight: 30 to 50 parts of EL-40, 1 to10 parts of 1,2-propylene glycol, 1 to 10 parts of thymol and an sufficient amount of distilled water. According to the thymol nanoemulsion and the preparation method thereof, a thymol nanoemulsion prescription is screened by drawing a pseudo-ternary phase diagram, and the prepared thymol nanoemulsion has a particle size of 10 to 100nm and high stability; the obtained nanoemulsion is oil-in-watertype nanoemulsion, can be infinitely diluted with water, and under a transmission electron microscope, is spherical and nonadhesive. Detection with the transmission electron microscope shows that thediameters of drops are distributed between 10 and 100nm and the nanoemulsion is apparently yellow or colorless transparent liquid and has high stability.

Description

Technical field [0001] The invention relates to the field of nanoemulsion preparation, and specifically refers to a thymol nanoemulsion and a preparation method thereof. Background technique [0002] Nanoemulsion, also known as microemulsion, is a thermodynamically stable, isotropic, transparent or translucent particle with a particle size of 1 to 100nm formed spontaneously from water, oil, EL-40 and 1,2-propanediol. Homogeneous dispersion system. Generally speaking, nanoemulsions are divided into three types, namely oil-in-water nanoemulsion (O / W), water-in-oil nanoemulsion (W / O) and bicontinuous nanoemulsion (B.C) , this dispersion system was first discovered and reported by Hoar and Schulman in 1943. It was not until 1959 that Schulman proposed the concept of "microemulsion". Since then, the theoretical and applied research on nanoemulsion has developed rapidly. Currently, nanoemulsion The technology has penetrated into fields such as daily chemicals, fine chemicals, pet...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/05A61K47/44A61K47/10A61P1/02A61P11/04A61P31/10A61P23/02A61P27/16A61P11/00A61P11/10
Inventor 姜迪蛟
Owner CHENGDU LINGXI SHANGPIN TECH CO LTD
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