A dual-phase tissue engineering scaffold

A dual-phase tissue and engineering technology, applied in tissue regeneration, prosthesis, coating, etc., can solve problems such as abnormal growth of fibrous tissue, infectious diseases, adverse effects of traditional surgery, etc., to promote regeneration and healing, simple preparation, and accelerated Effect of decellularization process

Active Publication Date: 2022-05-24
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, surgical treatment such as direct suture, allograft and autograft can improve the quality of tendon-cartilage interface injury repair to a certain extent, but there are still obvious limitations to be solved, such as abnormal growth of fibrous tissue at the defect site, infectious diseases and Immune rejection, etc., these have caused serious adverse effects on traditional surgery

Method used

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  • A dual-phase tissue engineering scaffold
  • A dual-phase tissue engineering scaffold
  • A dual-phase tissue engineering scaffold

Examples

Experimental program
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Embodiment Construction

[0021] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0022] like Figure 1 to Figure 3 As shown, an embodiment of the biphasic tissue engineering scaffold of the present invention includes a cartilage scaffold 1 and a tendon scaffold 2 that are stacked and integrated in sequence from top to bottom. The other end of 1 is transversely cut with a plurality of cartilage book pages 12 extending to the cartilage fixation wrapping part 11, and cartilage differentiation cell sheets 13 are arranged between each cartilage book page 12; one end of the tendon support 2 is set for tendon fixation The wrapping part 21, the other end of the tendon support 2 is transversely cut with a plurality of tendon-like book pages 22 extending to the teno-fixation wrapping part 21, and a tendon differentiation cell sheet 23 is arranged between the tendon-like book pages 22; the cartilage support 1. The cartilage-l...

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Abstract

The invention discloses a two-phase tissue engineering support, which comprises a cartilage support and a tendon support stacked and integrated sequentially from top to bottom. The cartilage leaf sheet extending to the cartilage-fixed wrapping part, and the cartilage-differentiated cell sheet is arranged between each cartilage-like book sheet; one end of the tendon support is set as the tendon fixation wrapping part, and the other end of the tendon support is cut transversely with multiple The tendon leaf sheet extends to the tendon-like leaf of the tendon-fixed wrapping part, and there is a tendon-like leaf sheet between each tendon-like leaf; the cartilage-like leaf at the bottom of the cartilage scaffold is connected with the tendon-like leaf at the top of the tendon scaffold. The biphasic tissue engineering scaffold has the advantages of simple preparation, convenient use, reduced decellularization time, and improved repair quality.

Description

technical field [0001] The invention mainly relates to a repairing technique for tendon cartilage interface damage, in particular to a biphasic tissue engineering scaffold. Background technique [0002] Bone-tendon interface injuries caused by sports trauma are very common in the field of sports medicine. The bone-tendon interface is a composite structure composed of tendon-fibrocartilage-bone. Histologically, it can be subdivided into four layers: tendon, unmineralized fibrocartilage, mineralized fibrocartilage and bone. Because it is difficult to restore the normal tissue structure after bone-tendon interface injury, and the mechanical properties of the repair site are poor, how to improve the repair quality of bone-tendon interface injury is a major challenge for clinicians. [0003] The repair of bone-tendon interface injury involves two parts: tendon-cartilage interface and cartilage-bone interface injury repair. Among them, the injury repair of tendon-cartilage inter...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/36A61L27/34
CPCA61L27/34A61L27/3604A61L27/3612A61L2430/10A61L2430/06A61L2400/18C08L89/00
Inventor 吕红斌胡建中瞿瑾李骁宁陈灿
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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