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Antibacterial alginate composite functional dressing and preparation method thereof

A composite function, alginate technology, applied in the field of medical biopolymer materials, can solve problems such as limited wound healing ability, achieve the effects of good biocompatibility and biosafety, small medicinal amount, and low cost input

Inactive Publication Date: 2017-12-15
WUHAN YIJIABAO BIOMATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the ability of pure alginate dressings to promote wound healing is limited, so the development of alginate dressings with other functions will be the focus of future research

Method used

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  • Antibacterial alginate composite functional dressing and preparation method thereof
  • Antibacterial alginate composite functional dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1 Dissolve sodium alginate and sodium carboxymethylcellulose in purified water at a mass ratio of 9:1, stir mechanically at a stirring speed of 800 rpm / min, and dissolve at a temperature of 40°C. After the solution is completely dissolved and forms a viscous solution, use After degassing under reduced pressure and filtered under reduced pressure, the spinning stock solution is formed, which will be extruded through the spinneret hole into a coagulation bath containing calcium ions. The calcium ion coagulation bath is an aqueous or alcohol solution of 10 wt.% calcium salt, and the spinning The speed is 20m / min to form solid alginate fiber filaments. The filaments are stretched, washed with water, dehydrated and dried, crimped to form fibers.

[0028] 2 Prepare a 2 vt.% acetic acid solution, dissolve an appropriate amount of chitosan in the acetic acid solution to prepare a 0.04 g / ml chitosan solution, pour the chitosan solution into the dipping tank, and immerse the guid...

Embodiment 2

[0032] An in vitro degradation test was carried out on the antibacterial alginate composite functional dressing prepared in Example 1.

[0033] Simulated body fluid preparation: The formula of simulated body fluid is: 8.035g NaCl; 0.355g NaHCO3; 0.225g KCl; 0.231g K2HPO4 3H2O; 0.311g MgCl2 3H2O; 1~5ml 1.0M HCl. The temperature of the prepared solution needs to be kept at 36.5±1.5°C. During the preparation, the reagents should be added in order to adjust the pH to 7.40.

[0034]In vitro degradation test: Take a 10 cm × 10 cm alginate dressing, dry it to constant weight, and weigh it. Place the dried dressing in a 250mL Erlenmeyer flask, add 150mL simulated body fluid, seal it and sterilize it at 121°C for 20min. After the sterilization was completed, the Erlenmeyer flask was cooled to room temperature, and then placed in a shaker at 37°C to simulate degradation. Sampling was carried out at the following time points (1, 5, 10, 15, 20, 25 and 30d), and 3 parallel samples were ...

Embodiment 3

[0039] The antibacterial alginate composite functional dressing prepared in Example 1 was subjected to a rabbit ear artery hemostasis test.

[0040] Select healthy male New Zealand rabbits and divide them into medical gauze group and alginate dressing group. The ears of New Zealand rabbits were depilated and disinfected, and anesthetized by slowly injecting 3% sodium pentobarbital into the marginal ear vein of the rabbits at a rate of 30 mg / kg body weight. On the outer third of the ear, cut a wound with a length of 1 cm with a sterilized scalpel, so that the central aorta of the ear was incised but not penetrated. After 3 s, the wound was filled with blood and immediately covered with a pre-weighed hemostatic material ( 2 cm×3 cm), and covered with weighed medical gauze, 50 g weight for oppression to stop bleeding. Start timing while covering the dressing, and use the weighed cotton to absorb the bleeding around it, and time it every 10 s. If the wound does not ooze within 20...

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Abstract

The invention relates to an antibacterial alginate composite functional dressing and a preparation method thereof. The dressing is prepared from alginate, sodium carboxymethylcellulose, chitosan and a guanidine antibacterial agent and has good biosecurity, bleeding stopping performance and antibacterial performance. The preparation method comprises the steps as follows: firstly, sodium alginate and sodium carboxymethylcellulose are dissolved, the solution is extruded into a calcium ion coagulating bath via spinneret orifices, and fiber filaments are formed; then, a chitosan solution is prepared, and prepared alginate fiber is subjected to chitosan coating; next, a guanidine antibacterial agent solution is prepared and the fiber is impregnated in the guanidine antibacterial agent solution; finally, composite fiber is subjected to combing, needling and hot rolling treatment, cutting, packaging and sterilization are performed, and the dressing is prepared. The preparation method is simple and low in production cost. The prepared antibacterial alginate composite functional dressing has good antibacterial performance and can meet wound bleeding stopping, antibacterial and healing promoting requirements.

Description

technical field [0001] The invention belongs to the field of medical biopolymer materials, and relates to an antibacterial alginate composite functional dressing and a preparation method thereof. Background technique [0002] Bacterial infection produced during wound healing and a large number of inflammatory factors, proteases and free radicals contained in the exudate will slow down the recovery. Research experiments have confirmed that the healing effect of wounds in a moist environment is better than that in an open dry environment, and a theory of moist wound healing is proposed. At present, clinical requirements for wound dressings should not only have basic functions such as exudate control and bacterial growth inhibition, but also have good hygroscopicity, sealing performance, easy removal and antibacterial properties. [0003] Alginic acid is a kind of polysaccharide extracted from marine plants, which is bonded by α-L-guluronic acid (G) and β-D-mannuronic acid (M)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/20A61L15/42A61L15/44A61L15/46A61L15/64
CPCA61L15/20A61L15/28A61L15/42A61L15/44A61L15/46A61L15/64A61L2300/206A61L2300/404A61L2400/04C08L5/04C08L1/284C08L5/08
Inventor 柯林松雷勇夏田
Owner WUHAN YIJIABAO BIOMATERIAL CO LTD
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