Soluble microneedle for delivering proteins or peptides

A protein and microneedle technology, applied in the field of soluble microneedles for protein or peptide delivery, can solve the problems of increased molecular weight of peptides and difficulty in improving skin absorption

Active Publication Date: 2017-12-05
LG HOUSEHOLD & HEALTH CARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, in this case, the molecular weight of the peptide increases, and there is a problem that it is substantially difficult to improve skin absorption

Method used

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  • Soluble microneedle for delivering proteins or peptides
  • Soluble microneedle for delivering proteins or peptides
  • Soluble microneedle for delivering proteins or peptides

Examples

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Embodiment Construction

[0072] In order to facilitate understanding of the present invention, examples are given below in detail. However, various modifications can be made to the examples of the present invention, and the scope of the present invention is not limited to the following examples. The embodiments of the present invention are provided to more completely describe the present invention to those skilled in the art.

[0073]

[0074] First, 1 g of polylactic-co-glycolic acid (PLGA) was dissolved in 10 mL of methylene chloride (MethyleneChloride). A solution of 200 mg of polypeptide (epidermal growth factor, EGF) dissolved in 2 mL of purified water was slowly added to the PLGA solution to make the first W / O emulsion. The W / O emulsion produced for the first time was added to a 0.2% polyvinyl alcohol aqueous solution (100 mL) with stirring. The thus-produced W / O / W double emulsion was stirred at room temperature for 24 hours, methylene chloride as an organic solvent was evaporated, and EGF-l...

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Abstract

The present invention relates to a skin administration system capable of ensuring the stability of peptides or proteins and enhancing the delivery rate of peptides or proteins through the skin and, more particularly, to a microneedle comprising peptides or proteins.

Description

technical field [0001] This application claims the benefit of Korean Patent Application 10-2015-0048462 filed on April 6, 2015, Korean Patent Application 10-2015-0159966 filed on November 13, 2015, Korean Patent Application filed on April 6, 2015 Patent application 10-2015-0048471, the priority of Korean patent application 10-2015-0144873 filed on October 16, 2015, is hereby incorporated by reference as if fully disclosed herein. [0002] The present invention relates to a soluble microneedle, a transdermal drug delivery system capable of stably delivering protein or peptide to skin, and a transdermal drug delivery system with improved stability of unstable protein or peptide. Background technique [0003] In recent years, in order to improve skin conditions (eg, wrinkles, elasticity, etc.), products containing growth factors (epidermal growth factor (EGF), human growth hormone (hGH), transforming gowth factor α and β) are being developed. (Transforming growth factor TGF-α,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/00A61K38/18A61K38/08A61K38/07A61K38/06A61K8/64A61K8/02A61M37/00A61Q19/00A61Q19/08A61P17/18
CPCA61K8/0204A61K8/64A61K9/0021A61K38/06A61K38/07A61K38/08A61K38/18A61M37/0015A61Q19/08A61M2037/0053A61K38/05A61K38/27A61K47/38A61K47/36A61K47/34A61K47/32A61P17/00A61K8/735A61K8/731A61K8/8129A61K8/8176A61K8/85A61M2037/0046A61K2800/91A61K38/1808A61K9/0024A61K9/1647A61K8/027A61K9/7023A61K2800/412A61P17/18A61K8/0208A61K38/00A61M37/00A61K8/02A61K9/70
Inventor 沈愚先李鲜和黄英暋姜来圭
Owner LG HOUSEHOLD & HEALTH CARE LTD
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