Compound undecylenic nanoemulsion and preparation method thereof
A technology of nanoemulsion and enoic acid, which is applied in the field of medicine, can solve the problems of low bioavailability, high irritation, and high volatility, and achieve the effects of improving solubility, storage stability, and high thermodynamic stability
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Embodiment 1
[0049] EL40 24.37g, absolute ethanol 3.15g, triacetin 3.00g, undecylenic acid 3.90g, cinnamaldehyde 0.80g, eugenol 0.80g, distilled water 63.98g.
[0050] Above-mentioned each component is made compound undecylenic acid nano-emulsion, comprises the following steps:
[0051] 1) Weigh the surfactant according to the formula, use it alone or compound it with the surfactant or co-surfactant in proportion, calculate the HLB value of the system, and stir well;
[0052] 2) Mix undecylenic acid, cinnamaldehyde, and eugenol according to the formula or mix them with one or more oils, and stir well;
[0053] 3) Mix the surfactant obtained in step 1) with the oil obtained in step 2), stir evenly, then slowly add distilled water dropwise to the mixture, and stir while adding, the mixture system will change from thin to viscous during the process of adding water and stirring Thick, and finally a series of changes from thick to thin, until the formation of nanoemulsions.
Embodiment 2
[0055] EL40 25.47g, ethyl oleate 3.50g, undecylenic acid 2.50g, cinnamaldehyde 1.00g, eugenol 2.50g, distilled water 65.03g.
Embodiment 3
[0057] RH40 22.80g, absolute ethanol 7.15g, 1,2-propanediol 2.00g, undecylenic acid 5.18g, cinnamaldehyde 2.00g, eugenol 0.5g, distilled water 60.37g.
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