Preparation method of nonionic vesicle with whitening effect
A non-ionic, non-ionic surface technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of poor product stability, single whitening mechanism, and low whitening efficiency, and achieve the goal of overcoming poor stability and improving Stability, the effect of simplifying the formulation process
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Embodiment 1
[0035] A preparation method of non-ionic vesicles with whitening effect:
[0036] A. Weigh the traditional whitening agent, hydroxyphenoxypropionic acid, phloretin, hydroxytyrosol, and blue ear root extract according to the mass ratio of 3:1:3:2:1, wherein the traditional whitening agent is Glabridin and nicotinamide with a mass ratio of 1:1; the whitening active composition and dipropylene glycol are mixed in a mass ratio of 1:5 and heated to 70~80 o C, stirring at a low speed with an ordinary propeller stirrer until it is clear and transparent, and cooling to room temperature to obtain a whitening active composition solution;
[0037] B. Weigh glycerol oleate citrate, cetearyl glucoside, polyglycerol-3 methylglucose distearate by mass ratio 0.5: 2: 1 to form a nonionic surfactant mixture, After mixing, heat to 50~60°C, mix honokiol and non-ionic surfactant mixture according to the mass ratio of 1:10, then stir at low speed with a common propeller stirrer until it is clear a...
Embodiment 2
[0041] A preparation method of non-ionic vesicles with whitening effect:
[0042] A. Weigh the traditional whitening agent, hydroxyphenoxypropionic acid, phloretin, hydroxytyrosol, and blue ear root extract according to the mass ratio of 5:1:3:2:1, wherein the traditional whitening agent is Arbutin and 4-butylresorcinol with a mass ratio of 1:1; the whitening active composition and 1,3-butanediol are mixed in a mass ratio of 1:6 and heated to 70~80 o C, stirring at a low speed with an ordinary propeller stirrer until it is clear and transparent, and cooling to room temperature to obtain a whitening active composition solution;
[0043] B. Take glyceryl oleate citrate, cetearyl glucoside, polyglycerol-3 methylglucose distearate by mass ratio 1.5: 2: 1 to form a nonionic surfactant mixture, After mixing, heat to 50~60°C, mix honokiol and non-ionic surfactant mixture according to the mass ratio of 1:10, then stir at low speed with a common propeller stirrer until it is clear and...
Embodiment 3
[0047] A preparation method of non-ionic vesicles with whitening effect:
[0048] A. Weigh the traditional whitening agent, hydroxyphenoxypropionic acid, phloretin, hydroxytyrosol, and blue ear root extract according to the mass ratio of 6:1:3:2:1, wherein the traditional whitening agent is Ascorbyl glucoside and ascorbyl palmitate with a mass ratio of 1:1; the whitening active composition and glycerin are mixed in a mass ratio of 1:8 and heated to 70~80 o C, stirring at a low speed with an ordinary propeller stirrer until it is clear and transparent, and cooling to room temperature to obtain a whitening active composition solution;
[0049] B. Take glyceryl oleate citrate, cetearyl glucoside, polyglycerol-3 methylglucose distearate by mass ratio 2.5: 2: 1 to form a nonionic surfactant mixture, After mixing, heat to 50~60°C, mix honokiol and non-ionic surfactant mixture according to the mass ratio of 1:10, then stir at low speed with a common propeller stirrer until it is cle...
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