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Production method of medical artificial skin

A technology of artificial skin and production method, applied in medical science, prosthesis, etc., can solve the problems of incomplete safety guarantee, complex and cumbersome preparation process, residual organic solvents, etc., achieve shortened preparation cycle and good skin biocompatibility , no harm to human body and environment

Inactive Publication Date: 2017-11-21
江西高大生物医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After testing, the porous silicon rubber film prepared by this method has a smaller pore size, although it can resist the invasion of external bacteria to a certain extent, but the gas permeability is not strong; Long, low production efficiency; at the same time, a series of organic solvents need to be used in the preparation process. On the one hand, the volatilization of organic solvents and waste liquid will cause great harm to the environment. On the other hand, there are Possibility of residual organic solvents, its safety cannot be fully guaranteed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A method for producing medical artificial skin, specifically comprising the steps of:

[0026] A. According to the mass percentage, take 65% of injection addition type liquid silicone rubber component A and 35% of purified water, mix and stir evenly at room temperature, and the stirring speed is 1500r / min to obtain mixture 1.

[0027] B. According to the mass percentage, take 65% of the injection addition type liquid silicone rubber component B and 35% of purified water, mix and stir evenly at room temperature, and the stirring speed is 1500r / min to obtain the mixture 2.

[0028] C. According to the mass percentage, take 50% of the mixture 1 and 50% of the mixture 2, mix and stir evenly at room temperature, the stirring speed is 500r / min, and obtain the mixture 3.

[0029]D. Input the mixture three into the salivation machine for salivation film formation, solidify after the salivation film formation, the curing temperature is 70°C, the curing time is 35 minutes, and th...

Embodiment 2

[0033] A method for producing medical artificial skin, specifically comprising the steps of:

[0034] A. According to the mass percentage, take 70% injection addition type liquid silicone rubber component A and 30% purified water, mix and stir evenly at room temperature, and the stirring speed is 2300r / min to obtain mixture 1.

[0035] B. According to the mass percentage, take 70% of injection addition type liquid silicone rubber component B and 30% of purified water, mix and stir evenly at room temperature, and the stirring speed is 2300r / min to obtain mixture 2.

[0036] C. According to the mass percentage, take 50% of the mixture 1 and 50% of the mixture 2, mix and stir evenly at room temperature, the stirring speed is 500r / min, and obtain the mixture 3.

[0037] D. Input the mixture three into the salivation machine for salivation film formation, solidify after the salivation film formation, the curing temperature is 80°C, the curing time is 30 minutes, and then evaporate ...

Embodiment 3

[0041] A method for producing medical artificial skin, specifically comprising the steps of:

[0042] A. According to the mass percentage, take 75% of injection addition type liquid silicone rubber component A and 25% of purified water, mix and stir evenly at room temperature, and the stirring speed is 3000r / min to obtain mixture 1.

[0043] B. According to the mass percentage, take 75% of the injection addition type liquid silicone rubber component B and 25% of purified water, mix and stir evenly at room temperature, and the stirring speed is 3000r / min to obtain the mixture 2.

[0044] C. According to the mass percentage, take 50% of the mixture 1 and 50% of the mixture 2, mix and stir evenly at room temperature, the stirring speed is 500r / min, and obtain the mixture 3.

[0045] D. Input the mixture three into the salivation machine for salivation film formation, solidify after the salivation film formation, the curing temperature is 90°C, the curing time is 25 minutes, and t...

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PUM

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Abstract

The invention discloses a production method of a medical artificial skin. The method comprises the following steps: according to steps A-E, feeding a component A and a component B of injecting and forming liquid silicone rubber according to a certain mass ratio under a certain condition, separately mixing the component A and the component B with purified water uniformly at first, then mixing the component A and the component B uniformly under a certain condition, feeding the mixture into a slobbering machine and carrying out slobbering film forming, curing and evaporating at the specifically selected temperature and for a specifically selected time, and then carrying out steps such as puncturing, slitting and rolling to obtain the finished medical artificial skin. The method is simple, convenient and practical, is short in preparation period and high in efficiency, does not use organic solvents in a production process, is safe and environmentally friendly, meanwhile can provide a wet environment for a wound to facilitate healing of the wound, and is not adhered to the wound when used, so that pain of a patient when the medical artificial skin is changed is relieved; and moreover, the produced medical artificial skin is good in resistance of bacteria and breathability.

Description

technical field [0001] The invention belongs to the field of preparation of medical polymer materials, and in particular relates to a production method of medical artificial skin. Background technique [0002] The skin is the outermost structure of the human body and the largest organ of the human body. It is not only a sensory organ of the nervous system, but also an effector. Mechanical and chemical stimuli such as cold, heat, pain, and emotional changes all reflexively cause skin vasoconstriction and relaxation, arrector pili muscle contraction, sweat gland secretion, and skin capillary permeability. sexual change. The skin covers the whole body, and it protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microorganisms. [0003] The skin is a natural barrier to protect the body. For patients with severe skin defects, a large amount of body fluid loss and wound infection are the main factors that threaten the lives of patien...

Claims

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Application Information

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IPC IPC(8): A61L27/60A61L27/18A61L27/08A61L27/02
CPCA61L27/025A61L27/08A61L27/18A61L27/60C08L83/04
Inventor 郭勇夏和生罗高兴李雪波何显文曾凡平
Owner 江西高大生物医疗科技有限公司
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