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Emulsion composition containing 25-hydroxyvitamin d3 and preparation method thereof

A technology of hydroxyvitamin and emulsion composition, which is applied in the field of animal health care, can solve the problems of demulsification, poor product stability, high viscosity, etc., and achieve the effect of improving bone density or bone strength, good preparation stability, and good stability

Active Publication Date: 2021-04-02
ACT PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wherein, its emulsion dosage form is the state that the microencapsulated oil composition has not been spray-dried, and its viscosity is very high, is unfavorable for practical application
Moreover, 25-hydroxyvitamin D3 is unstable under conventional preparation conditions, resulting in a time-dependent loss of activity per unit dose. Especially at higher temperatures, the active ingredient is easy to degrade, and this degradation is harmful to 25-hydroxyvitamin D3 during use. Dosage of Vitamin D3 Adversely Affects
Chinese patent 201610070588.7 discloses a quick-acting energy-enhancing compound vitamin microemulsion preparation for pigs. The cost of medium-chain triglycerides in more than 80% of the composition is relatively high, and the obtained water-in-oil microemulsion will be diluted during use. It is inconvenient to use due to demulsification, it is necessary to prevent rancidity during storage, the stability of the product is poor, and the requirements for the preparation, storage and transportation of the product are more stringent

Method used

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  • Emulsion composition containing 25-hydroxyvitamin d3 and preparation method thereof
  • Emulsion composition containing 25-hydroxyvitamin d3 and preparation method thereof
  • Emulsion composition containing 25-hydroxyvitamin d3 and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052]The composition composition of the emulsion composition containing 25-hydroxy vitamin D3 is shown in Table 2:

[0053]Table 2

[0054] Composition Position / g Prescription ratio / % effect 25-hydroxy vitamin D3 1.5840.176Active ingredient Medium chain triglyceride 63.07.00Oil dispersion phase 2,6-di-tert-butyl-4-methylphenol 9.01.00Antioxidant Single oil glycerol 21.92.44Ionure emulsifier Tween-60 41.14.50Hydrophilic emulsifier water 763.484.8Continuous phase total About 900g 100--

[0055]The emulsion composition containing 25-hydroxy vitamin D3 is prepared by the following processes:

[0056]1, oil phase preparation:

[0057]The water bath is maintained at a water bath temperature, and the medium chain glycerol is added to the beaker, the temperature is detected to 70 ° C; the amount of 2,6-di-tert-butyl-4-methylphenol is added thereto, and the magnetic stirring equipment is employed. The stirring was dissolved, stirred for 15 min; the amount of 25-hydroxy vitamin D3 was added, s...

Embodiment 2

[0072]The composition of the emulsion composition containing 25-hydroxy vitamin D3 is shown in Table 4:

[0073]Table 4

[0074]

[0075]The emulsion composition containing 25-hydroxy vitamin D3 is prepared by the following processes:

[0076]1, oil phase preparation:

[0077]The water bath is maintained at a water bath temperature, and the medium chain glycerol is added to the beaker, the temperature is detected to 70 ° C; the amount of 2,6-di-tert-butyl-4-methylphenol is added thereto, and the magnetic stirring equipment is employed. The stirring was dissolved, stirred at 15 min; the amount of 25-hydroxy vitamin D3 was added, stirred, stirred, stirred for 60 min.

[0078]2, emulsifier preparation

[0079]Mix the monohydrate and Tween-20 and Tween-20 in the beaker;

[0080]3, early milk preparation

[0081]When the equivalent emulsifier is poured into the oil phase, stir the mixture to form colosmia, stir for 5 min;

[0082]4, water treatment

[0083]The aqueous phase maintains 70 ° C in the water bath, spare;

[008...

Embodiment 3

[0092]Stability Test: The sample prepared by the case 1 and the case 2 was placed under 25 ° C, 60% RH, and the content, traits, pH, etc. were examined.

[0093]The stability results are shown in Table 6:

[0094]Table 6

[0095]

[0096]The results show that the case 1 and the case 2 have good stability, and under the conditions of acceleration of 25 ° C, 60% RH, it is stable for 90 days.

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Abstract

The invention discloses an emulsion composition containing 25-hydroxyvitamin D3 and a preparation method thereof. The emulsion composition is prepared from an active ingredient 25-hydroxyvitamin D3, a lipophilic emulsifier, a hydrophilic emulsifier, an antioxidant, a disperse-phase oil-phase solvent and a continuous-phase aqueous-phase solvent. According to the invention, a more stable oil-in-water type emulsion dosage form is prepared by optimizing the emulsifier dosage and proportion and adjusting the types and proportions of the aqueous phase and oil phase; a product has high stability and is convenient to prepare, transport and store and more suitable for industrial application; the emulsion prepared by the preparation method can maintain relatively high preparation stability and can be dispersed in drinking water at a fixed dosage; thus, the 25-hydroxyvitamin D3 can be applied to feed for poultry and pigs more conveniently, and improves the bone density or bone strength as a nutritional supplement for the poultry and pigs.

Description

Technical field[0001]The present invention belongs to the field of animal health, and more particularly to an emulsion composition containing 25-hydroxy vitamin D3 and a preparation method thereof.Background technique[0002]Vitamin D (eg, wheat calculus D2 and girderoxide d3) is a group of fat-soluble compounds defined by biologically active, vitamin D can promote the reconnection of bone, and also regulate the function of cardiovascular, immunized and muscle system. Epidemiological study found vitamin D intake and its association between blood pressure or glucose metabolism. The activity of vitamin D is negative feedback control of the thyroid hormone. Vitamin D lacks disease in children, causing bone softening in adults. However, in a monthly chronic intake of more than 100 times, it is recommended that the daily allowable amount (i.e., 5 ~ 15μg or 200 ~ 600Iu), toxicity may occur after vitamin D, which can occur at the blood calcium at a blood of 375 nmol / l25 hydroxy vitamin D. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K20/174A23K50/30A23K50/75A23K40/30
CPCA23K20/174A23K40/30A23K50/30A23K50/75
Inventor 单鹏达张德臣
Owner ACT PHARMA CO LTD
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