Purification preparation method of methadone standard substance used in forensic science drug testing

Abstract

The invention discloses a purification preparation method of a methadone standard substance used in forensic science drug testing. The method comprises the following steps: detecting the purity of methadone in captured methadone samples, and selecting the captured methadone sample with a methadone mass fraction greater than or equal to 50 wt% as a raw material for purification preparation of the methadone standard substance; (2) using a high performance liquid chromatography to prepare the methadone standard substance. The methadone obtained by using the purification preparation method is confirmed by means of nuclear magnetic resonance, and liquid chromatography-series mass spectrometry and infrared spectrum analysis, the purity of the methadone is determined and valued by means of liquid chromatography and gas chromatography, and impurities having no response to the chromatography are measured; according to the development requirements for the standard substances, the stability, uniformity, valuing and estimation of total uncertainty of the methadone standard substance meet the relevant regulations and reach the expected indexes.

Description

technical field [0001] The invention relates to the preparation of forensic science drug standard products. More specifically, it relates to a method for purifying and preparing methadone standard substances used in forensic drug detection. Background technique [0002] At present, the increasingly serious drug problem has become a global disaster. The proliferation of drugs directly endangers people's physical and mental health, and poses a huge threat to economic development and social progress. Therefore, establishing a forensic scientific drug detection quantity traceability system, improving the measurement technology of drug components, ensuring the reliability and comparability of measurement results, establishing the sharing and mutual recognition of measurement data, and providing accurate and reliable evidence for courts has become a national standard in the world. A general concern of drug identification agencies. [0003] Drug composition measurement technolog...

AI Technical Summary

Problems solved by technology

All of these bring certain uncertainties to the detection of drug-related cases, which directly affect the accuracy of quantitative results.

Moreover, the lack of domestic drug standard substances has become a major obstacle restricting my country from realizing the standardization of forensic scientific drug detection chemical measurement methods, traceability and mutual recognition of measurement results.

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