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Method for preparing mesoporous silicon nanoparticle coating loaded with heparin and Cu<2+> on surface of biological material

A technology of nanoparticles and biomaterials, applied in coatings, drug delivery, pharmaceutical formulations, etc., can solve the problem that the fixed amount of heparin on the surface is difficult to ensure the long-term sustained effect of implanted materials in blood vessels, and it is difficult to ensure the sustained and controlled release of heparin. Its activity and other issues can achieve good blood compatibility, improve the success rate of implantation, and improve the effect of biocompatibility

Active Publication Date: 2017-09-15
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently commonly used heparinization methods (such as ionic bonding, electrostatic adsorption, covalent binding, etc.) are difficult to ensure the sustained and controlled release behavior and activity of heparin, and the fixed amount of heparin on the surface is also difficult to ensure the long-term durability of intravascular implant materials. role requirements

Method used

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  • Method for preparing mesoporous silicon nanoparticle coating loaded with heparin and Cu&lt;2+&gt; on surface of biological material
  • Method for preparing mesoporous silicon nanoparticle coating loaded with heparin and Cu&lt;2+&gt; on surface of biological material
  • Method for preparing mesoporous silicon nanoparticle coating loaded with heparin and Cu&lt;2+&gt; on surface of biological material

Examples

Experimental program
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Effect test

Embodiment 1

[0046] Preparation of heparin and Cu on the surface of biomaterials 2+ A method for coating mesoporous silicon nanoparticles, comprising the steps of:

[0047] 1) Firstly, the surface of mesoporous silicon nanoparticles is modified to obtain MSN-NH 2 ;

[0048] 2) Then load heparin and Cu in the mesoporous channels 2+ ;

[0049] 3) Then modify the surface of nanoparticles with albumin;

[0050] 4) Finally, the nanoparticles were immobilized on the surface of dopamine-modified biomaterials to obtain MSN-NH 2 Coating of @He / Cu.

[0051] In the step 1), the surface modification method of mesoporous silicon nanoparticles is as follows:

[0052] 1.1) Fully mix mesoporous silicon nanoparticles and aminosilane molecular solution;

[0053] 1.2) Shake the reaction for 30 hours, and collect the nanoparticles by centrifugation;

[0054] 1.3) Wash with ethanol three times;

[0055] 1.4) MSN-NH was obtained after vacuum drying at 80 degrees Celsius 2 .

[0056] In the step 1.1),...

Embodiment 2

[0074] Preparation of heparin and Cu on the surface of biomaterials 2+ A method for coating mesoporous silicon nanoparticles, comprising the steps of:

[0075] 1) Firstly, the surface of mesoporous silicon nanoparticles is modified to obtain MSN-NH 2 ;

[0076] 2) Then load heparin and Cu in the mesoporous channels 2+ ;

[0077] 3) Then modify the surface of nanoparticles with albumin;

[0078] 4) Finally, the nanoparticles were immobilized on the surface of dopamine-modified biomaterials to obtain MSN-NH 2 Coating of @He / Cu.

[0079] In the step 1), the surface modification method of mesoporous silicon nanoparticles is as follows:

[0080] 1.1) Fully mix mesoporous silicon nanoparticles and aminosilane molecular solution;

[0081] 1.2) Shake the reaction for 30 hours, and collect the nanoparticles by centrifugation;

[0082] 1.3) Wash with ethanol three times;

[0083] 1.4) MSN-NH was obtained after vacuum drying at 80 degrees Celsius 2 .

[0084] In the step 1.1),...

Embodiment 3

[0102] Preparation of heparin and Cu on the surface of biomaterials 2+ A method for coating mesoporous silicon nanoparticles, comprising the steps of:

[0103] 1) Firstly, the surface of mesoporous silicon nanoparticles is modified to obtain MSN-NH 2 ;

[0104] 2) Then load heparin and Cu in the mesoporous channels 2+ ;

[0105] 3) Then modify the surface of nanoparticles with albumin;

[0106] 4) Finally, the nanoparticles were immobilized on the surface of dopamine-modified biomaterials to obtain MSN-NH 2 Coating of @He / Cu.

[0107] In the step 1), the surface modification method of mesoporous silicon nanoparticles is as follows:

[0108] 1.1) Fully mix mesoporous silicon nanoparticles and aminosilane molecular solution;

[0109] 1.2) Shake the reaction for 30 hours, and collect the nanoparticles by centrifugation;

[0110]1.3) Wash with ethanol three times;

[0111] 1.4) MSN-NH was obtained after vacuum drying at 80 degrees Celsius 2 .

[0112] In the step 1.1), ...

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Abstract

The invention discloses a method for preparing a mesoporous silicon nanoparticle coating loaded with heparin and Cu<2+> on the surface of a biological material. The method comprises the steps of carrying out surface modification on mesoporous silicon nanoparticles to obtain amino-modified mesoporous silicon nanoparticles to load heparin and Cu<2+> into a mesoporous duct; modifying the surfaces of the nanoparticles by using albumin; and finally fixing the nanoparticles on the surface of the dopamine-modified biological material to obtain the mesoporous silicon nanoparticle coating loaded with the heparin and the Cu<2+>. Surface modification is carried out on a material or device implanted into a blood vessel by adopting the method, so that the loading capacity and the release behavior of the heparin and the Cu<2+> on the surface of the material can be effectively controlled, the material is endowed with good blood compatibility and regeneration of blood vessel endothelium can be significantly promoted, thereby effectively improving the biocompatibility and the implant success rate of the material.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a method for preparing heparin and Cu on the surface of biological materials. 2+ A method for the coating of mesoporous silicon nanoparticles. Background technique [0002] The anticoagulant performance and endothelial repair performance of the surface of intravascular implant materials or devices (such as vascular stents, artificial blood vessels, etc.) are still the main problems in their clinical application, and the response to the surrounding environment of implantation can be adjusted by changing the surface properties of materials. Improving the performance and function of implanted materials is of great significance to the clinical application of intravascular implanted materials or devices. So far, many surface modification technologies have been used to improve the anticoagulant properties of materials and induce endothelial regeneration in situ, but the e...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/10A61L31/14A61L31/16A61L33/00
CPCA61L31/088A61L31/10A61L31/14A61L31/16A61L33/0011A61L2300/102A61L2300/232A61L2300/412A61L2300/606A61L2400/18A61L2420/02A61L2420/06C08L5/10C08L79/02C08L89/00
Inventor 潘长江刘涛龚韬
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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