Film agent containing alkannin and resisting oral ulcer inflammation and preparation and application thereof

Abstract

The invention discloses a film agent containing alkannin and resisting oral ulcer inflammation, and preparation and application thereof. The film agent is prepared from the following materials in parts by weight: 0.01--0.05 part of alkannin, 1-3 parts of gamma-cyclodextrin, 0.25-15 parts of chitosan quaternary ammonium salt, 0.5-5 parts of polyvinylpyrrolidone K90, 5-30 parts of bletilla hyacinthine gum, 0.5-2 parts of gelatin, 3-10 parts of ethyl cellulose, 90-97 parts of alcohol and 20-50 parts of distilled water. The film forming agent is prepared according to a certain method and comprises two layers, namely a complete drug-loaded film and a blank film, one side of the drug-loaded film is stuck to the affected part, the blank film can stop drug from dissolving out in an oral cavity, so that the effect of one-way drug release is achieved, simultaneously bad taste of main medicines is covered, the drug is gathered to the affected part, the treating effect is improved, further the pain of patients is greatly relieved and the action time of the medicines is prolonged; and the effective-component alkannin in the medicine film has the anti-inflammation and bacteriostatic effects, namely inflammation diminishing, astringency and antipyresis. Simultaneously, the film agent is convenient to store and carry and can be easily industrialized.

Description

technical field [0001] The invention relates to the field of medical medicaments, in particular to an anti-oral ulcer inflammation film containing shikonin, a preparation method and application thereof. Background technique [0002] Oral ulcers, also known as recurrent aphthous ulcers, are the most common oral mucosal diseases with a high incidence rate and very easy to relapse. Clinically, it mainly manifests as round or oval small erosions scattered in the oral cavity, surrounded by congestion and edema, and patients often feel pain, which affects daily life activities such as eating and speaking. At present, it is believed that the main pathogenic factors of oral ulcers are related to the decline of the body's immune function. In addition, endocrine factors and mental factors will also affect the onset. Diabetes and those with low immune function will delay the healing time of ulcers. But so far, there is no medicine or method in the world that can completely cure oral u...

AI Technical Summary

Problems solved by technology

[0006] Purpose of the invention: In order to overcome the problems in the prior art that the film preparations for oral ulcers have good antibacterial and anti-inflammatory effects on wounds, but it is difficult to avoid drug resistance and allergic reactions, the present invention proposes a film-forming, waterproof It can prevent wound infection and promote wound healing without causing allergic reactions and drug resistance in patients, and it is convenient to carry the anti-oral ulcer inflammation film containing shikonin and its preparation method and application