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Novel production process of trollius chinensis heat clearing effervescent tablet

A production process and technology for effervescent tablets, applied in the field of effervescent tablets, can solve problems such as inability to disintegrate, and achieve the effects of being conducive to disintegration, increasing specific surface area, and increasing roughness

Inactive Publication Date: 2017-08-04
TIANJIN HORUS CANDK PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Added excipients include acids and bases. Acids and bases are directly mixed with extract powder and compressed into tablets. Generally, acids and bases will not react in the absence of water. However, a small amount of Water, causing acid and alkali ionization reaction, cannot disintegrate after long-term storage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A new production process of Jinlian Qingre Effervescent Tablets, including granulation, tablet compression, and internal packaging procedures.

[0025] The innovation point of the present invention is:

[0026] A drying program is added between the tablet pressing and inner packaging programs.

[0027] Specific steps are as follows:

[0028] (1) Add water and decoct twice by weight: Nasturtium: Daqingye: Gypsum: Anemarrhena: Rehmannia glutinosa: Scrophulariae: fried bitter almonds = 2:2:1.5:1:1:1:1.5, the first Add 7-8 times the amount of water for the first time, decoct for 2 hours; add 5-6 times the amount of water for the second time, decoct for 1 hour, and combine the decoction;

[0029] (2) The decoction is spray-dried to obtain a dry extract powder, and after adding certain auxiliary materials, the mixed material is pressed into a sheet with a pressure wheel;

[0030] (3) The sheet material obtained in step (2) is crushed into suitable particles by a crushing m...

Embodiment 2

[0036] The difference from Example 1 is that the drying temperature is 50°C.

Embodiment 3

[0038] The difference from Example 1 is that the drying temperature is 55°C.

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PUM

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Abstract

The invention relates to a new production process of Jinlian Qingre Effervescent Tablets, which includes granulation, tablet compression, and internal packaging procedures. A drying procedure is added between the tablet compression and internal packaging procedures. The drying process is to put the compressed tablets into In an oven, under normal pressure, adjust the temperature to 45-55°C, and dry for 24-72 hours. The new process is further dried after tablet molding to remove moisture in the tablet, avoid acid-base reaction, and improve the stability of the tablet for long-term storage.

Description

technical field [0001] The invention belongs to the field of effervescent tablets, and relates to a production process of effervescent tablets, in particular to a new production process of Jinlian heat-clearing effervescent tablets. Background technique [0002] An effervescent tablet is a tablet that contains an effervescent disintegrant. So-called effervescent disintegrating agent is usually the mixture of organic acid and sodium carbonate, sodium bicarbonate (baking soda); effervescent tablet itself is dry and does not contain moisture, and the two materials in the effervescent disintegrating agent are not ionized and cannot react; but When the effervescent tablet is put into water, the two substances undergo an acid-base reaction to generate a large amount of carbon dioxide, causing the tablet to disintegrate and melt rapidly. [0003] Usually, the production process of effervescent tablets includes the following procedures in sequence: batching, granulation, tabletting...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K36/8964A61P29/00A61K33/06
CPCA61K9/0007A61K9/20A61K33/06A61K36/195A61K36/315A61K36/704A61K36/71A61K36/736A61K36/804A61K36/808A61K36/855A61K36/8964A61K2236/331A61K2236/39A61K2236/51
Inventor 王建强王春磊许培立
Owner TIANJIN HORUS CANDK PHARMA CO LTD
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