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Ivermectin slow release injection

A technology of ivermectin and injection, applied in the direction of drug delivery, organic active ingredients, medical preparations containing active ingredients, etc., can solve the problems of different products, different product quality, and restrictions on the wide application of oral preparations, and achieve irritating Small size, low cost, and remarkable insect repellent effect

Inactive Publication Date: 2017-07-25
哈尔滨生物制品二厂有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the bioavailability of oral administration is only 41% of that of injection, this limits the wide application of oral preparations.
Although ivermectin injections have been developed now, different solvents are used in the preparation, which causes different problems in product quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] In this example, the ivermectin sustained-release injection is prepared from the following raw materials in parts by weight: 0.5g ivermectin, 4.0g glycerin formal, 15g propylene glycol, 3.5g ethyl cellulose, 7g oil Ethyl acetate, 0.25g Tween-80.

[0017] Concrete preparation steps are as follows:

[0018] 1) Weigh 0.5g ivermectin, 4.0g glycerol formal, 15g propylene glycol, 3.5g ethyl cellulose, 7g ethyl oleate, 0.25g Tween-80;

[0019] 2) Add ivermectin, glycerin formal, propylene glycol, ethyl cellulose, ethyl oleate and nonionic surfactant into the liquid preparation tank, stir at 25°C to dissolve all ivermectin, Filtering, potting, and sterilizing the ivermectin sustained-release injection.

Embodiment 2

[0021] In this example, the ivermectin sustained-release injection is prepared from the following raw materials in parts by weight: 0.3g ivermectin, 2.0g glycerin formal, 12g propylene glycol, 2.5g ethyl cellulose, 5g oil Ethyl acetate, 0.25g Tween-60.

[0022] Concrete preparation steps are as follows:

[0023] 1) Weigh 0.3g ivermectin, 2.0g glycerin formal, 12g propylene glycol, 2.5g ethyl cellulose, 5g ethyl oleate, 0.25g Tween-60;

[0024] 2) Add ivermectin, glycerin formal, propylene glycol, ethyl cellulose, ethyl oleate and nonionic surfactant into the liquid preparation tank, stir at 15°C to dissolve all ivermectin, Filtering, potting, and sterilizing the ivermectin sustained-release injection.

Embodiment 3

[0026] In this example, the ivermectin sustained-release injection is prepared from the following raw materials in parts by weight: 0.3g ivermectin, 3.0g glycerin formal, 14g propylene glycol, 3g ethyl cellulose, 6g oleic acid Ethyl ester, 0.3g Tween-40.

[0027] Concrete preparation steps are as follows:

[0028] 1) Weigh 0.4g ivermectin, 3.0g glycerin formal, 14g propylene glycol, 3g ethyl cellulose, 6g ethyl oleate, 0.3g Tween-40;

[0029] 2) Add ivermectin, glycerin formal, propylene glycol, ethyl cellulose, ethyl oleate and nonionic surfactant into the liquid preparation tank, stir at 20°C to dissolve all ivermectin, Filtering, potting, and sterilizing the ivermectin sustained-release injection.

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PUM

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Abstract

The invention discloses an ivermectin slow release injection, which is prepared from the following raw materials in parts by weight: 0.2 to 0.6 part of ivermectin, 1.5 to 4.5 parts of glycerol formal, 10 to 16 parts of propanediol, 2 to 4 parts of ethyl cellulose, 4 to 8 parts of ethyl oleate, 0.2 to 0.4 part of non-ionic surface active agents, wherein the non-ionic surface active agents are tween-80, tween-60 or tween-40. The propanediol and the glycerol formal are used as a solvent and a latent solvent; the ethyl oleate is used as a slow release agent; the product quality and the bioavailability can be well improved; the anthelminthic effect is obvious; the pharmacological activities of the ivermectin can be sufficiently achieved, so that the medicine effect is improved; a better solving scheme is provided for clinically expelling and treating parasites in bodies of livestock.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and relates to an ivermectin sustained-release injection for expelling parasites in livestock. Background technique [0002] Ivermectin is a new type of broad-spectrum, high-efficiency, and low-toxic antibiotic antiparasitic drug. It has good repellent effects on internal and external parasites, especially nematodes and arthropods. It is effective against larvae, and it is also effective against faecal garden filariae that are only in the intestinal tract. [0003] Ivermectin is widely used clinically, and the blood drug peaks in 2 to 4 hours after oral administration to livestock and poultry. However, because the bioavailability of oral administration is only 41% of that of injection, this limits the wide application of oral preparations. Although the ivermectin injection has been developed now, different solvents are used in the preparation, so that there are different problems in pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/10A61K47/14A61K31/7048A61P33/00
CPCA61K9/08A61K9/0002A61K9/0019A61K31/7048A61K47/10A61K47/14
Inventor 马兰孙玉胜
Owner 哈尔滨生物制品二厂有限责任公司
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