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Coated tablet of pepsin

A technology of pepsin and coated tablets, applied in the field of medicine, can solve the problems of unsatisfactory effect of pepsin tablets, too little pepsin, curing the symptoms but not the root cause, etc., and achieves the effect of solving indigestion symptoms

Inactive Publication Date: 2017-07-11
THE THIRD PEOPLES HOSPITAL OF QINGDAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Abnormal gastric sensory function and hypersensitivity of visceral nerves may increase the responsiveness of FD patients to various stimuli
The existing pepsin tablets only simply provide the pepsin needed by the human body, but they cannot fundamentally solve the essential problem of too little pepsin secreted by the principal cells of the gastric glands. In addition, pepsin needs to be activated by gastric acid to make pepsinogen Become active pepsin and provide a suitable acidic environment for pepsin. The secretion of gastric acid and pepsin reflects the digestive function of the stomach for food
At the same time, different enzymes have different optimal pH values, and the optimal pH value of pepsin is 1.8. Therefore, if a suitable gastric environment cannot be provided first, the effect of simply taking pepsin tablets is often not ideal, and the symptoms are not cured.

Method used

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  • Coated tablet of pepsin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A pepsin-coated tablet, consisting of a tablet core and a coating film, is characterized in that, based on the mass of the coated tablet, the tablet core contains 5% clove leaf extract, 5% hawthorn extract, Pepsin 0.01%, sucrose powder 75%, sodium starch glycolate 2%, magnesium stearate 0.3%.

[0021] The clove leaf extract is prepared by the following method: use the supercritical fluid extraction method, crush the medicinal material to 40-80 mesh, place it in the extraction pool, select the extraction temperature to be 45°C, the extraction pressure to be 14MPa, and the extraction time to be 45°C. The experiment was carried out for 2 hours and the carbon dioxide flow rate was 20L / h. The extract was extracted three times with 5% sodium hydroxide, acidified with 6mol / L hydrochloric acid until the blue litmus paper showed acidity; Sodium-dried, diethyl ether evaporated to obtain a light yellow oily liquid, which was spray-dried to obtain an ultra-fine powder with a water ...

Embodiment 2

[0027]A pepsin-coated tablet, consisting of a tablet core and a coating film, is characterized in that, based on the mass of the coated tablet, the tablet core contains 7% of clove leaf extract, 7% of hawthorn extract, Pepsin 0.015%, sucrose powder 70%, sodium starch glycolate 3%, magnesium stearate 0.5%.

[0028] The clove leaf extract is prepared by the following method: use the supercritical fluid extraction method, crush the medicinal material to 40-80 mesh, place it in the extraction pool, select the extraction temperature to be 40°C, the extraction pressure to be 12MPa, and the extraction time to be 40°C. The experiment was carried out for 3 hours and the flow rate of carbon dioxide was 15L / h. The extract was extracted three times with 5% sodium hydroxide, acidified with 6mol / L hydrochloric acid until the blue litmus paper showed acidity; Sodium-dried, diethyl ether evaporated to obtain a light yellow oily liquid, which was spray-dried to obtain an ultra-fine powder with...

Embodiment 3

[0034] A pepsin-coated tablet is composed of a tablet core and a coating film. Based on the mass of the coated tablet, the tablet core contains 10% clove leaf extract, 10% hawthorn extract, and 0.02% pepsin , 65% sucrose powder, 4% sodium starch glycolate, 1% magnesium stearate.

[0035] The clove leaf extract is prepared by the following method: use the supercritical fluid extraction method, crush the medicinal material to 40-80 mesh, place it in the extraction pool, select the extraction temperature to be 50°C, the extraction pressure to be 14MPa, and the extraction time to be 50°C. The experiment was carried out for 5 hours and the carbon dioxide flow rate was 20L / h. The extract was extracted three times with 5% sodium hydroxide, acidified with 6mol / L hydrochloric acid until the blue litmus paper showed acidity; Sodium-dried, diethyl ether evaporated to obtain a light yellow oily liquid, which was spray-dried to obtain an ultra-fine powder with a water content of ≤5% and ab...

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Abstract

The invention specifically relates to a coated tablet of pepsin, belonging to the field of medicines. The coated tablet of pepsin is composed of a tablet core and a coating film. The tablet core comprises, in terms of the mass of the coated tablet, 5 to 10% of clove leaf extract, 5 to 10% of haw extract and 0.01 to 0.02% of pepsin. The invention has the following advantages: a novel recipe is provided for a pepsin tablet; and since the clove leaf extract and the haw extract are added, the energy of the main cells and wall cells of the gastric gland can be activated and normal pepsinogen and gastric acid secretion capability is allowed to be recovered, so the problem of extremely low secretion of pepsin is fundamentally overcome, an appropriate acidic environment is provided for pepsin, the effect of pepsin is given to full play, and the symptoms of dyspepsia are eliminated.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a pepsin-coated tablet. Background technique [0002] Functional dyspepsia (FD) is a group of clinical syndromes with upper abdominal pain, discomfort, fullness, belching, loss of appetite and nausea as the main symptoms, and organic diseases causing these symptoms are excluded after examination. In recent years, the prevalence rate has been high, and the statistics in European and American countries have reached 19%-41%, with an average of 32%; in China, it has been 18%-45%, accounting for 20%-40% of patients with digestive tract diseases. [0003] The pathogenesis of FD is still unclear, and it may be closely related to gastrointestinal motor dysfunction and sensory dysfunction. Psychological and neurological factors, as well as environment, diet, gastrointestinal hormones, gastric acid and HP infection are involved in the pathogenesis, while strong tea, alcohol, high Fatty food and co...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K9/28A61K9/42A61K47/36A61K47/46A61P1/14A61K36/734
CPCA61K38/488A61K9/2059A61K9/2813A61K9/282A61K9/2826A61K36/61A61K36/734A61K2236/19A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2236/55C12Y304/23001A61K2300/00
Inventor 张国联
Owner THE THIRD PEOPLES HOSPITAL OF QINGDAO
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