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Radix astragali and radix puerariaegranule fingerprint spectrum and construction method thereof

A technique for fingerprinting and establishing methods, which is applied to the construction method of HPLC fingerprints of Qige granules and the field of fingerprints, which can solve the problems of inability to describe and evaluate the quality of Qige granules, complex chemical composition, and difficulty in fully reflecting the chemistry of Qige granules. Issues such as the type and quantity of ingredients, to achieve the effect of improving safety and effectiveness, high stability, and high precision

Active Publication Date: 2017-07-07
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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Problems solved by technology

Astragalus membranaceus, kudzu root, and tangerine peel contain complex chemical components, and the qualitative and quantitative analysis of individual components is difficult to fully reflect the types and quantities of chemical components contained in Qige granules, and it is impossible to describe and evaluate the quality of Qige granules as a whole

Method used

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  • Radix astragali and radix puerariaegranule fingerprint spectrum and construction method thereof
  • Radix astragali and radix puerariaegranule fingerprint spectrum and construction method thereof
  • Radix astragali and radix puerariaegranule fingerprint spectrum and construction method thereof

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Embodiment Construction

[0024] The present invention will be further described in detail through the following specific examples and accompanying drawings to facilitate the understanding of the technical solution of the present invention, but the embodiments of the present invention are not limited thereto.

[0025] 1. Preparation of Qige Granules:

[0026] (1) Remove impurities and wash astragalus, kudzu root, and tangerine peel, then soak in water 12 times the total weight of the medicinal materials for 30 minutes, boil with strong fire, simmer for 30 minutes, pour out the decoction, and decoct 3 times according to the same method, Combine the three decoctions, mix and stir well;

[0027] (2) concentrating the water decoction of step (1) to an extract whose relative density is 1.3, for subsequent use;

[0028] (3) Measure the weight of the extract in step (2), add the mixture of powdered sugar and dextrin, wherein the weight ratio of extract, powdered sugar and dextrin is 1:3:1, mix well and make ...

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Abstract

The invention discloses a method for establishing aradix astragaliand radix puerariae granuleHPLC (high performance liquid chromatography) fingerprint spectrum. The method comprises the steps: performing gradient elution by adopting an HPLC method to acquire an radix astragali and radix puerariae granule common mode fingerprint spectrum; analyzing the radix astragali and radix puerariae granulefingerprint spectrum information to acquire 22 common peaks; calculating the relative retention time and the relative peak area of the common peaks by taking daidzin as reference peak; and authenticating 12 common peaks through a control product comparison method. According to the method provided by the invention, the types and the quantity of the chemical components in the radix astragali and radix puerariae granules are reflectively comprehensively, so that the quality is subjected to global description and evaluation, the quality is effectively represented, comprehensive quality detection and overall quality control are benefited, and the clinical use safety and effectiveness of the medicine are improved. Meanwhile, the method provided by the invention has high stability, high precision degree, high repeatability and the like.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to a method for constructing an HPLC fingerprint of Qige granules and a fingerprint thereof. Background technique [0002] Fingerprint is an internationally recognized effective means to control the quality of traditional Chinese medicine or traditional Chinese medicine compound. It is based on the systematic research on the chemical components of traditional Chinese medicine and is mainly used to evaluate the authenticity, goodness and stability of the quality of Chinese medicinal materials and traditional Chinese medicine preparations. sex. Under certain conditions, fingerprints can fully reflect the relative amounts of components contained in traditional Chinese medicine or traditional Chinese medicine compound, so that the quality control index of traditional Chinese medicine and traditional Chinese medicine compound can be raised from the content determination of a single componen...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/86
CPCG01N30/02G01N30/8686
Inventor 柯雪红李东晓黄可儿方志刚代汝伟秦书敏冯小权罗艳
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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