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Tibetan medicine composition used for viral pneumonia

A technology of viral pneumonia and composition, applied in the field of medicine, can solve the problems of large toxic and side effects, low cure rate and the like

Inactive Publication Date: 2017-07-04
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing therapeutic drugs are antiviral agents, antibiotics or hormones, which have great toxic and side effects on the human body and a low cure rate

Method used

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  • Tibetan medicine composition used for viral pneumonia
  • Tibetan medicine composition used for viral pneumonia
  • Tibetan medicine composition used for viral pneumonia

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0039] Experimental example 1, anti-influenza virus pneumonia pharmacodynamics experiment

[0040] 1. Experimental materials

[0041] Viruses: Type A H1N1, H2N2, H5N1 and Type B influenza viruses, cited from Institute of Virology, Chinese Academy of Preventive Medicine. After recovery, the virus amplifies and multiplies in the allantoic cavity of healthy fertilized chicken eggs and mice, and is stored at -80°C for later use.

[0042] Animals: BALB / c mice, 5-7 weeks old, half male and half female, body weight 12±2g, SPF grade, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. Animal certificate number: SCXK (Beijing) 2012— 2013.

[0043] Drug prescription: Gentiana flower 33g, crab carapace 48g, myrobalan 50g, sandalwood 11g, rock cabbage 30g, clove 11g, japonica 31g, gentiana gentiana 9g, and fenugreek 10.

[0044] Drug preparation:

[0045] Add water to decoct all the medicinal materials twice, add 10 times the amount of water for the first time, ...

experiment example 2

[0078] Experimental example 2, the effect of medicine of the present invention on respiratory syncytial virus pneumonia in vivo

[0079] 1. Experimental materials

[0080] The virus species Respiratory syncytial virus (RSV) Long strain was quoted from the Virus Laboratory of the Institute of Virology, Chinese Academy of Preventive Medicine, and the human laryngeal carcinoma cell line (Hep-2 cells), provided by the Microbiology Laboratory of the Basic Institute of Shandong Academy of Medical Sciences; BALB / c mice , 5-7 weeks, half male and half male, body weight 12±1g, SPF grade, cited from Shandong University Animal Center, SPF grade animal license number: SCXX (Lu) 2013004; Ribavirin, Yantai No. 2 Pharmaceutical Factory, batch number 20140617 . The drug preparation is the same as in Experimental Example 1.

[0081] 2. Experimental method

[0082] 1. Virus half infection dose (TCID50)

[0083] Use Hep-2 cell monolayer culture, inoculate 7 concentrations of 10-fold diluted ...

Embodiment 1

[0104] Embodiment 1, a kind of Tibetan medicine composition for viral pneumonia, the composition is as follows: Gentiana chinensis 33g, crab carapace 48g, myrobalan 50g, sandalwood 11g, rock cabbage 30g, clove 11g, ditch grass 31g, big flower gentian 9g and fenugreek 10g are used for the preparation of medicines for treating H1N1 viral pneumonia.

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Abstract

The invention provides a Tibetan medicine composition used for viral pneumonia. Results of animal experiments show that high dose of the Tibetan medicine composition enables the inhibition rate of the lung index of a mouse with pneumonia caused by influenza A H1N1 viruses, influenza A H2N2 viruses, influenza A H5N1 viruses, influenza B viruses and respiratory syncytial viruses (RSVs) to be greater than 40%; the lung index of a model mouse having taken the composition has no significant difference compared with the lung index of a normal mouse from a control group; medium dose and low dose of the composition also have substantial inhibitory effect, with the inhibition rates both greater than 15%; the Tibetan medicine composition can substantially reduce the mortality of mice caused by infection with RSVs and substantially resist reduction in the spleen indexes and thymus indexes of mice infected with RSVs; and the Tibetan medicine composition can substantially improve the immunologic functions of mice with RSV viral pneumonia and reduce the mortality of the mice.

Description

technical field [0001] The invention relates to a Tibetan medicine composition for viral pneumonia, which belongs to the field of medicine. Background technique [0002] At present, the pathogenic status of viruses in pneumonia has attracted more and more attention. In particular, the emergence of coronavirus, avian influenza virus A (H5N1), and pandemic influenza virus A (H1N1) has once again aroused people's attention to severe pneumonia caused by respiratory virus infection. The incidence of viral pneumonia and the aggravation of its symptoms. It is estimated that about 4 million people die from viral pneumonia every year in the world. This disease has become the third leading cause of death after ischemic heart disease and cerebrovascular disease. The demand for drugs to relieve and treat this disease is increasing Big. [0003] Viral pneumonia is caused by adenovirus, respiratory syncytial virus, influenza virus, parainfluenza virus, Coxsackie virus, echovirus, etc. ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P31/12A61P31/16A61P31/14A61P11/00
Inventor 张义智李怀平王海苹艾洛加马宏伟
Owner SHANDONG JINHE DRUG RES DEV
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