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Traditional Chinese medicine composition for treating coronary heart disease and preparation method thereof

A composition and technology for coronary heart disease, applied in drug combination, pharmaceutical formulation, drug delivery, etc., can solve unresolved clinical problems and achieve good application prospects, clear curative effect, and low toxicity

Inactive Publication Date: 2017-06-23
青岛友诚高新技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Modern medicine has made significant progress in drug intervention and interventional therapy, but many clinical problems remain unsolved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) A Chinese medicine for the treatment of coronary heart disease, which is formed by the proportioning of the following raw materials by weight:

[0034] 30 parts of lip vanilla, 25 parts of ginseng reed, 20 parts of hairy rabbit lip flower, 15 parts of an umbrella, 15 parts of Gan Mutong, 10 parts of ginkgo leaf, 10 parts of Chuanqiong, 10 parts of long-tube bat grass, 10 parts of poria cocos, tooth 5 parts of Ye Liwu and 5 parts of white milk mushroom.

[0035] (2) Preparation method:

[0036] In the first step, the ginseng reed and the rhizoma chinensis are mixed in proportion, extracted twice with n-propanol having an alcohol concentration of 70% which is equivalent to twice the mass of the mixture, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder, Then purify with ethanol for 1-2 times, combine the extracts, recover the ethanol under reduced pressure and concentrate to a paste with a relative density of 1.21-1...

Embodiment 2

[0041](1) A kind of Chinese medicine for the treatment of coronary heart disease is formed by the proportioning of following raw materials by weight: same as embodiment 1.

[0042] (2) Preparation method:

[0043] In the first step, the ginseng reed and the rhizoma chinensis are mixed in proportion, extracted twice with n-propanol having an alcohol concentration of 70% which is equivalent to twice the mass of the mixture, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder, Then purify once with ethanol, combine the extracts, recover ethanol under reduced pressure and concentrate to a paste with a relative density of 1.21-1.24 at 60°C, dry and pulverize into powder;

[0044] In the second step, an umbrella, Ganmusong, ginkgo leaves, and Chuanqiong are extracted twice with n-propanol with an alcohol concentration of 80%, and the extracts are combined, concentrated under reduced pressure, dried, and pulverized into powder, and th...

Embodiment 3

[0048] 1. Long-term toxicity test process:

[0049] Apply Wistar rats (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. provides) experimental medicine is set to high, medium and low three dosages, be respectively the capsule 8g / kg, 4g / kg, 2g of embodiment 1 formula / kg. Calculated according to the human dose of 0.1g / kg / day tablet, it is 80 times, 40 times and 20 times of the effective dose for human respectively; another control group is set up, which is given continuously for 90 days and 180 days by intragastric administration and part of the animals are withdrawn for 10 days. Days later, the effects on various physiological and biochemical indicators of rats were observed. The experimental results show that: continuous oral administration of different doses to rats for 180 days has no effect on the food intake and weight growth of the rats. No significant toxic effects were found on liver and kidney function. There was no obvious effect on blood routine, bl...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating coronary heart disease, which comprises: lip balsam, ginseng reed, hazel lip flower, an umbrella, Gan Mutong, ginkgo leaf, Chuan Qiong, long-tube bat grass, poria cocos, and Lignus serrata , white milk mushroom, the invention also discloses the preparation method of the above-mentioned traditional Chinese medicine composition. This kind of traditional Chinese medicine composition is prepared with pure traditional Chinese medicine. It has the characteristics of low toxicity and good curative effect of natural medicine. It has clear curative effect on coronary heart disease and treats both symptoms and root causes. The effect of improving blood flow and improving myocardial ischemia is low in price, easy to make, and has good application prospects.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a traditional Chinese medicine composition for treating coronary heart disease and a preparation method thereof. Background technique [0002] Coronary atherosclerotic heart disease is a heart disease caused by atherosclerotic lesions in the coronary arteries that cause stenosis or blockage of the vessel lumen, resulting in myocardial ischemia, hypoxia or necrosis. It is often called "coronary heart disease". However, the scope of coronary heart disease may be wider, including inflammation, embolism, etc. leading to stenosis or occlusion of the lumen. The World Health Organization divides coronary heart disease into five categories: asymptomatic myocardial ischemia (occult coronary heart disease), angina pectoris, myocardial infarction, ischemic heart failure (ischemic heart disease) and sudden death. Clinically, it is often divided into stable coronary artery disease and acute coronary ...

Claims

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Application Information

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IPC IPC(8): A61K36/716A61K9/48A61K9/08A61P9/10
CPCA61K36/716A61K9/0019A61K9/08A61K9/1652A61K36/07A61K36/076A61K36/16A61K36/236A61K36/258A61K36/28A61K36/29A61K36/48A61K36/53A61K47/02A61K2236/331A61K2236/333A61K2236/39A61K2236/51
Inventor 不公告发明人
Owner 青岛友诚高新技术有限公司
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