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Cefixime oral preparation

A technology of cefixime and oral preparations, applied in the field of pharmaceutical preparations, can solve the problems of poor suspensibility, solubility, and low bioavailability, and achieve the effects of high dissolution rate, simple production process, and good drug suspension effect

Inactive Publication Date: 2017-06-13
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cefixime granules, which are common in the market at present, have poor suspensibility and solubility, and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Prescription of Cefixime Granules (Specification: 50mg):

[0018] Cefixime 50.0 g

[0019] Lactose 895.0g

[0020] Tragacanth Gum 18.0 g

[0021] Xanthan Gum 24.0g

[0022] Hypromellose 12.0g

[0023] Magnesium stearate 1.0 g

[0024] A total of 1000 packs were made

[0025] Preparation:

[0026] Mix the prescription amount of cefixime with lactose, tragacanth gum, and xanthan gum evenly, and ball mill in a ball mill for 1

[0027] Take it out after 2 hours, and pass it through a 200-mesh standard sieve for later use; add an appropriate amount of hydroxypropyl cellulose aqueous solution, mix well, and make a soft material, granulate with a 24-mesh sieve, dry the wet granules at 50~55°C, granulate with a 24-mesh sieve, Add the prescribed amount of magnesium stearate into the sized granules, mix well, pack, and obtain.

Embodiment 2

[0029] Prescription of Cefixime Granules (Specification: 100mg):

[0030] Cefixime 100.0 g

[0031] Lactose 846.0g

[0032] Tragacanth Gum 15.0 g

[0033] Xanthan Gum 30.0g

[0034] Hypromellose 8.2g

[0035] Magnesium stearate 0.8 g

[0036] A total of 1000 packs were made

[0037] Preparation:

[0038] Mix the prescription amount of cefixime with lactose, tragacanth gum, and xanthan gum evenly, and ball mill in a ball mill for 1

[0039] Take it out after 2 hours, and pass it through a 200-mesh standard sieve for later use; add an appropriate amount of hydroxypropyl cellulose aqueous solution, mix well, and make a soft material, granulate with a 24-mesh sieve, dry the wet granules at 50~55°C, granulate with a 24-mesh sieve, Add the prescribed amount of magnesium stearate into the sized granules, mix well, pack, and obtain.

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PUM

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Abstract

The invention provides a cefixime oral preparation. The cefixime oral preparation comprises the following components in percentage by weight: 30 to 200 parts of cefixime as an active ingredient, 500 to 1000 parts of a filler, 30 to 80 parts of a suspending agent, 5 to 30 parts of a binding agent, and 0.4 to 5 parts of a lubricating agent. The cefixime oral preparation prepared by the invention is good in suspension effect and dissolubility, and the dissolution rate of the cefixime oral preparation reaches 95% and more than 95%. Furthermore, the cefixime oral preparation is high in bioavailability, solves the defects of poor solubility of the active ingredients and low bioavailability, and has stable quality and reliability, thereby extremely having market development prospects.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations and relates to an oral preparation of cefixime. The invention also provides an oral preparation of cefixime with good quality, safety and stability. Background technique [0002] Cefixime is white to light yellow crystalline powder, odorless, with slight specific odor, easily soluble in methanol, dimethyl sulfoxide, slightly soluble in acetone, hardly soluble in ethanol, almost insoluble in water, ethyl acetate, ether, in hexane. As the third-generation oral cephalosporin antibiotic, cefixime has a broad antibacterial spectrum and strong antibacterial activity. , Proteus mirabilis, and Neisseria gonorrhoeae (including enzyme-producing strains) all have good antibacterial activity, are stable to most β-lactamases, and have the advantages of small side effects. Streptococcus (except Enterococcus), pneumococcus, Neisseria gonorrhoeae, Branhamella catarrhalis, Escherichia coli, K...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/546A61K47/36A61K47/46A61P31/04
CPCA61K9/1652A61K9/1664A61K31/546
Inventor 曾培安曾灿丽朱长富吴健民刘娟
Owner KAMP PHARMA
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