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Drug-loaded protein microparticles and preparation method thereof

A technology of protein particles and proteins, applied in the field of materials science, can solve the problems of poor slow and controlled release of drugs, achieve significant technological progress, prolong the time of slow and controlled release, and prevent clogging problems

Active Publication Date: 2017-05-31
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a drug-loaded protein particle and a preparation method thereof. The drug-loaded protein particle and its preparation method should solve the problem of the drug-loaded protein particle in the prior art. The technical problem of the slow and controlled release effect of the drug is not good

Method used

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  • Drug-loaded protein microparticles and preparation method thereof
  • Drug-loaded protein microparticles and preparation method thereof
  • Drug-loaded protein microparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: Preparation of high-voltage electrostatic spraying working fluid

[0031] 12 g of zein and 2 g of ibuprofen were dissolved in 100 mL of a mixed solvent of acetic acid and ethanol, where the volume ratio of acetic acid:ethanol was 30:70.

[0032] The mixed solvent of acetic acid and ethanol with a volume ratio of 30:70 was used as the electrospray sheath fluid.

Embodiment 2

[0033] Example 2: Preparation of drug-loaded protein particles by ordinary single-jet high-voltage electrospray process

[0034] Put the eutectic solution of zein and 2 grams of ibuprofen into the syringe, install it on the syringe pump, use the metal capillary with an inner diameter of 0.6 mm as the nozzle, connect it directly to the front end of the syringe, connect the metal needle and DC high voltage Static generator. The flow rate of the working fluid was adjusted to 1.0 mL / h. When there are liquid droplets evenly dripping from the nozzle, start the high-voltage electrostatic generator. Under the working condition of applied voltage of 18 kV and receiving distance of 20 cm, a stable single-jet high-voltage electrostatic spraying process was started. Because proteins are easy to interact with metals, semi-solid adherent substances often hang on the nozzle during electrospray and block the nozzle (such as figure 1 shown). Therefore, these semi-solid substances composed...

Embodiment 3

[0035] Example 3 Preparation of Drug-Loaded Protein Particles by Acidic Solvent Circulation Coaxial High-voltage Electrospray Process

[0036] A co-dissolved solution of zein and 2 g of ibuprofen was filled into a syringe and fitted to a syringe pump. The mixed solvent of acetic acid and ethanol with a volume ratio of 30:70 was filled into another syringe as electrospray sheath fluid, and installed on another syringe pump. The above two working fluids are injected into the coaxial spray head through the pump. Connect the coaxial nozzle and the DC high voltage electrostatic generator. The flow rate of the working fluid in the core was adjusted to 0.7 mL / h, and the flow rate of the working fluid in the sheath to 0.3 mL / h. When there are liquid droplets evenly dripping from the nozzle, start the high-voltage electrostatic generator. Under the working condition of applied voltage of 18 kV and receiving distance of 20 cm, a stable coaxial high-voltage electrostatic spraying proc...

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Abstract

The invention provides drug-loaded protein microparticles. The drug-loaded protein microparticles are prepared from protein and a drug, wherein a mass ratio of the protein to the drug is (5 to 7) to 1; the shape of the drug-loaded protein microparticles is spherical or approximately spherical. The invention also provides a preparation method of the drug-loaded protein microparticles. The preparation method comprises the following steps: adopting a consolute solution of the protein and the drug as a core solution; adopting an acid mixed solvent as a sheath solution; respectively controlling the speed of injecting working fluid of the core solution and the sheath solution into a coaxial spray nozzle through two axial flow pumps, starting a high-voltage generator, atomizing and drying the working fluid of the core solution and the sheath solution after passing through the coaxial spray nozzle under the action of high-voltage static electricity, and collecting through a foil wrapped hard board, thus obtaining the drug-loaded protein microparticles which are spherical or approximately spherical. The high-voltage electrostatic spraying drug-loaded protein microparticles provided by the invention are capable of providing a better drug sustained or controlled release effect. A preparation technology of the invention is simple, single steps are effective, and an effective implementation method can be provided for design and preparation of many drug micro-nano sustained or controlled release dosing systems.

Description

technical field [0001] The invention belongs to the field of material science, and relates to a drug sustained and controlled release material, in particular to a drug-loaded protein particle and a preparation method thereof. Background technique [0002] High-voltage electrostatic spray technology (referred to as EFI) is a top-down (top-down) micro-nano manufacturing technology. This technology overcomes the surface tension and viscoelastic force of the liquid droplets at the tip of the nozzle by applying an electric field force to form a jet. Under the joint action of electrostatic repulsion, Coulomb force and surface tension, the atomized liquid evaporates quickly due to its huge surface area, and the polymer solute is dried into fine micro-nano particles. The technical process is simple, easy to operate, a wide range of polymer materials can be selected, strong controllability, and continuous industrial production can be realized. The application of this technology to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/192A61K47/42B01J13/04
CPCA61K9/0002A61K9/1658A61K31/192B01J13/043
Inventor 余灯广李海鹏王庆李娇娇周孙依
Owner UNIV OF SHANGHAI FOR SCI & TECH
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