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Vitamin D3 soft capsule and preparation method thereof

A vitamin and soft capsule technology, applied in the field of vitamin D3 soft capsules and its preparation, can solve the problems of low bioavailability and poor stability, and achieve the effects of extending shelf life, easy absorption, and enhancing integrity and stability

Active Publication Date: 2017-05-31
富诺健康股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve vitamin D in the prior art 3 Soft capsules have the defects of low bioavailability and poor stability. The purpose of the present invention is to provide a vitamin D 3 Soft capsule and preparation method thereof, to solve above-mentioned defect

Method used

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  • Vitamin D3 soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1, a kind of preparation of acylated gelatin

[0047] Prepare 70 parts of 3% bovine gelatin solution, add 2mol / L NaOH solution to adjust the pH value to 9.7, and put it in a water bath at a constant temperature of 65°C for 30 minutes; Amine tetraacetic dianhydride, adjust the pH value to 9.7, after the acylation reaction for 4 hours, dialyze the dialysis bag for 48 hours until the pH value of the water is 7, place it in a polyethylene glycol solution and concentrate to a protein concentration of 15%, then add 1 part 25% glutaraldehyde solution was cross-linked and solidified at 45° C. and 500 rpm / min constant temperature stirring for 60 minutes, aged at room temperature for 24 hours, frozen and dried to obtain the product.

Embodiment 2

[0048] Embodiment 2, a kind of vitamin D 3 soft capsule

[0049] The vitamin D 3 Soft capsules consist of contents and capsule shell:

[0050] The content consists of the following preparation raw materials and their parts by weight: Vitamin D 3 30 parts of powder and 40 parts of olive oil;

[0051] The vitamin D 3 The powder preparation method is:

[0052] A. 40 servings of vitamin D 3 , 50 parts of olive oil, 0.03 part of tert-butyl hydroquinone, 0.5 part of monoglyceride, heated to 45°C and stirred to obtain an oil phase;

[0053] B. Dissolve 5 parts of bovine gelatin, 20 parts of maltodextrin, 2 parts of sodium carboxymethylcellulose, and 3 parts of sucrose ester in 40 parts of purified water, heat to 45°C and stir to obtain the aqueous phase;

[0054] C. the oil phase obtained in step A is mixed with the water phase obtained in step B at a volume ratio of 1:1, homogenized 2 times under 20MPa conditions, each 20min, microemulsion, and the average particle diameter o...

Embodiment 3

[0066] Embodiment 3, a kind of vitamin D 3 soft capsule

[0067] The vitamin D 3 Soft capsules consist of contents and capsule shell:

[0068] The content consists of the following preparation raw materials and their parts by weight: Vitamin D 3 45 parts of powder and 55 parts of walnut oil;

[0069] The vitamin D 3 The powder preparation method is:

[0070] A. 48 Vitamin D 3 , 52 parts of walnut oil, 0.2 part of ethoxyquinoline, 0.8 part of glycerol monostearate, heated to 65 ° C and stirred to obtain an oil phase;

[0071] B. Dissolve 8 parts of soybean protein, 32 parts of β-cyclodextrin, 2 parts of sodium carboxymethyl cellulose, and 3 parts of sucrose ester in 60 parts of purified water, heat to 55°C, stir and mix to obtain the aqueous phase;

[0072] C. the oil phase obtained in step A is mixed with the water phase obtained in step B at a volume ratio of 1:1, homogenized 2 times under 40MPa conditions, each 30min, microemulsion, and the average particle diameter o...

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Abstract

The invention relates to the technical field of healthcare foods, and particularly relates to a vitamin D3 soft capsule and a preparation method thereof. The vitamin D3 soft capsule comprises a content and a capsule shell, wherein the content is prepared from vitamin D3 powder and vegetable oil; the capsule shell is mainly prepared from acylated gelatin, a stabilizer, polyethylene glycol 400, a colorant, a sweetening agent and purified water. The vitamin D3 soft capsule is subjected to targeted intestinal tract disintegration, is easily dissolved into water and can be directly absorbed by small intestines and colons, the damage of gastric acid to vitamin D3 passing through the stomach is avoided and the bioavailability is greatly improved; and meanwhile, the vitamin D3 soft capsule also has the advantages of high stability and good taste and popularization and application of the vitamin D3 soft capsule are greatly promoted.

Description

technical field [0001] The invention belongs to the technical field of health food, in particular to a vitamin D 3 Soft capsule and its preparation method. Background technique [0002] Vitamin D 3 It is a fat-soluble vitamin and one of the essential nutrients for the human body. It is mainly transformed from human subcutaneous cholesterol through ultraviolet irradiation, and can also be obtained from animal foods. Studies have shown that vitamin D 3 It has the effect of strengthening bones and can effectively prevent diseases such as rickets in children, osteoporosis in the elderly and tooth decay. At the same time, it plays an important role in the heart, blood vessels, nerves, immune and other systems, and is one of the essential elements for the human body. [0003] With the advancement of urbanization and changes in lifestyles in our country, the time for outdoor activities of the general public is decreasing, which affects the synthesis of vitamin D in the body. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/155A23L29/00A23P10/30A61K9/48A61K47/42A61K47/26A61K47/32A61K9/50A61K47/36A61K47/38A61K31/593A61P3/14A61P19/10
CPCA23V2002/00A61K9/4816A61K9/4825A61K9/5036A61K9/5042A61K9/5057A61K31/593A61K47/26A61K47/32A23V2200/30A23V2200/306A23V2250/18A23V2250/7106A23V2200/02A23V2200/222A23V2250/5118A23V2250/51082A23V2250/5432A23V2250/5488A23V2250/5114A23V2250/5112A23V2250/1614A23V2250/642A23V2200/04A23V2250/1634A23V2250/1592A23V2250/2482A23V2250/628A23V2250/192A23V2250/1842
Inventor 程彦任哲
Owner 富诺健康股份有限公司
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