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Liver clearing and toxin removing tablets and preparation method

A technology for clearing liver and detoxification, and Schisandra chinensis, which is applied in the directions of antiviral agents, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of low bioavailability, long disintegration time, low dissolution rate, etc. Simple, improved dissolution and bioavailability, low cost of production

Active Publication Date: 2017-05-24
恒拓集团广西圣康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention not only has good moisture-proof effect of the tablet, but also overcomes the defects of poor solubility, long disintegration time limit, slow effect, low dissolution rate and low bioavailability of the tablet, and is convenient to use, convenient to carry and store, stable in quality, The advantages of simple preparation process and low production cost

Method used

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  • Liver clearing and toxin removing tablets and preparation method
  • Liver clearing and toxin removing tablets and preparation method
  • Liver clearing and toxin removing tablets and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] A preparation method of Qingganjiedu tablet, comprising the following steps:

[0077] (1) Take each raw material according to the following parts by weight: 300 parts of Schisandra chinensis, 300 parts of Polygonum cuspidatum, 300 parts of Yexiazhu, 300 parts of Gynostemma pentaphyllum, 300 parts of Salvia miltiorrhiza, 200 parts of Ganoderma lucidum, 200 parts of charcoal mother, 200 parts of rhubarb, Bupleurum 200 parts, Liushenqu 200 parts, licorice root 200 parts, starch 500 parts, sucrose 150 parts, β-cyclodextrin 30 parts, sucrose fatty acid ester 90 parts, Cordyceps sinensis 150 parts, gelatin syrup 80 parts, simethicone 5 parts 200 parts magnesium stearate and 5000 parts ethanol.

[0078] (2) get Schisandra chinensis, Salvia miltiorrhiza and Bupleurum chinensis ethanol ultrasonic extraction 2 times, the add-on of ethanol for the first time is 7 times the weight of the medicinal material, the add-on for the second time is 6 times the weight of ethanol, and the ul...

Embodiment 2

[0083] A preparation method of Qingganjiedu tablet, comprising the following steps:

[0084] (1) Take each raw material according to the following parts by weight: 300 parts of Schisandra chinensis, 300 parts of Polygonum cuspidatum, 300 parts of Yexiazhu, 300 parts of Gynostemma pentaphyllum, 300 parts of Salvia miltiorrhiza, 200 parts of Ganoderma lucidum, 200 parts of charcoal mother, 200 parts of rhubarb, Bupleurum 200 parts, 200 parts Liushenqu, 200 parts licorice, 600 parts starch, 100 parts sucrose, 20 parts β-cyclodextrin, 100 parts sucrose fatty acid ester, 100 parts Cordyceps sinensis, 50 parts gelatin syrup, 10 parts simethicone 300 parts magnesium stearate and 6000 parts ethanol.

[0085] (2) get Schisandra chinensis, Salvia miltiorrhiza and Bupleurum chinensis ethanol ultrasonic extraction 2 times, the add-on of ethanol for the first time is 7 times the weight of the medicinal material, the add-on for the second time is 6 times the weight of ethanol, and the ultra...

Embodiment 3

[0090] A preparation method of Qingganjiedu tablet, comprising the following steps:

[0091] (1) Take each raw material according to the following parts by weight: 300 parts of Schisandra chinensis, 300 parts of Polygonum cuspidatum, 300 parts of Yexiazhu, 300 parts of Gynostemma pentaphyllum, 300 parts of Salvia miltiorrhiza, 200 parts of Ganoderma lucidum, 200 parts of charcoal mother, 200 parts of rhubarb, Bupleurum 200 parts, Liushenqu 200 parts, licorice 200 parts, starch 550 parts, sucrose 200 parts, β-cyclodextrin 40 parts, sucrose fatty acid ester 90 parts, Cordyceps sinensis 200 parts, gelatin syrup 100 parts, simethicone 8 parts parts, magnesium stearate 250 parts and ethanol 550 parts.

[0092] (2) get Schisandra chinensis, Salvia miltiorrhiza and Bupleurum chinensis ethanol ultrasonic extraction 2 times, the add-on of ethanol for the first time is 7 times the weight of the medicinal material, the add-on for the second time is 6 times the weight of ethanol, and the ...

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Abstract

The invention discloses liver clearing and toxin removing tablets and a preparation method thereof. The liver clearing and toxin removing tablets are prepared from the following raw materials in parts by weight: 300 parts of schisandra chinensis, 300 parts of polygonum cuspidatum, 300 parts of phyllanthus urinaria, 300 parts of gynostemma pentaphylla, 300 parts of salvia miltiorrhiza, 200 parts of lucid ganoderma, 200 parts of polygonum chinense, 200 parts of rheum officinale, 200 parts of radix bupleuri, 200 parts of medicated leaven, 200 parts of liquorice, 500-600 parts of starch, 100-200 parts of sucrose, 20-40 parts of beta-cyclodextrin, 80-100 parts of sucrose fatty acid ester, 100-200 parts of insect wax, 50-100 parts of gelatin syrup, 5-10 parts of dimeticone, 200-300 parts of magnesium stearate and 5,000-6,000 parts of ethanol. The liver clearing and toxin removing tablets disclosed by the invention not only realize a damp-proof effect, but also can overcome the defects of tablets of poor solubility, long disintegration time, slow effect, low dissolution rate and low bioavailability and have the characteristics of convenience in carrying, using and storing, simple preparation technology, low cost and high stability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a Qinggan Jiedu tablet and a preparation method. Background technique [0002] Liver-clearing and detoxifying drugs have the functions of clearing heat and detoxifying, removing dampness and relieving jaundice, and are suitable for the adjuvant treatment of hypochondral pain, jaundice, abdominal distension, anorexia, nausea and vomiting, yellow urine and yellow coating caused by damp-heat syndrome of hepatitis B and gallbladder. Existing liver-clearing and detoxifying drugs are mainly based on B-gan Qing-re-jiedu capsules. B-gan Qing-re-jiedu capsules have been used clinically in China for many years. Judging from the clinical use, their clinical efficacy is affirmed. However, the capsule dosage form is suitable for a narrow range of people, has low bioavailability, poor drug stability, and is prone to moisture. Therefore, in order to promote the diversifie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/40A61K9/36A61K47/36A61K47/40A61K47/26A61K47/44A61K47/34A61K36/79A61K36/708A61P1/16A61P31/20
CPCA61K9/2013A61K9/2018A61K9/2036A61K9/205A61K9/2059A61K9/2826A61K9/2873A61K36/00A61K36/074A61K36/233A61K36/424A61K36/47A61K36/484A61K36/537A61K36/57A61K36/704A61K36/708A61K36/79A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 苏军峰
Owner 恒拓集团广西圣康制药有限公司
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