Influenza vaccine nasal vaccination system

A flu vaccine, transnasal technology, applied in the direction of antibody medical ingredients, inorganic non-active ingredients, aerosol delivery, etc., to achieve strong immune induction, less side effects, and maintain antigenicity

Active Publication Date: 2017-04-19
TOKO YAKUHIN IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many problems in practical application, for example, how to reduce the toxicity of the adjuvant used to improve the immune induction, or how to design the drug delivery device to improve its use effect, etc.

Method used

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  • Influenza vaccine nasal vaccination system
  • Influenza vaccine nasal vaccination system
  • Influenza vaccine nasal vaccination system

Examples

Experimental program
Comparison scheme
Effect test

example 1

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[0088]

[0089] Virus stock solution example 1

[0090]

[0091] Virus stock solution example 2

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[0093]

[0094] Virus stock solution example 3

[0095]

[0096]

[0097] Each of the above-mentioned colloidal base example (1) and virus stock solution examples (1)-(3) is stirred and mixed at a ratio of 1:1, respectively, to prepare homogeneous influenza vaccine composition example 1 and example 2. and Example 3. The composition of the composition of each example and its physical properties / spray performance exhibited when sprayed using a spray device or a syringe-type sprayer are shown below. The stirring and mixing process can be done gently in a short time without stressing the inactivated whole virus antigen. In the resulting influenza vaccine composition, the amounts of the respective components and the spraying properties exhibited by spraying the composition using an appropriate device are shown below.

[0098] Example 1 ...

example 2

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example 3

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PUM

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Abstract

The present invention pertains to an influenza vaccine nasal vaccination system in which an influenza vaccine composition characterized by including a gel base that contains a carboxyvinyl polymer and an influenza virus deactivated full particle antigen, and including no adjuvants, is packed into a medical syringe for administration to the mucus membrane of the nasal cavity.

Description

technical field [0001] The present invention relates to a nasal vaccination system for use in conjunction with a medical syringe for administering an influenza vaccine composition to the nasal mucosa. Background technique [0002] Influenza is an acute respiratory infection caused by influenza virus, especially in winter. Also, influenza sometimes causes widespread epidemics that are severe enough to kill people. For influenza, influenza vaccination is known to have a certain preventive effect and can be widely administered before the epidemic season. [0003] The only influenza vaccine licensed in Japan is the inactivated protein component of the influenza virus antigen for subcutaneous inoculation, and its split vaccine is currently used as a seasonal influenza vaccine. This subcutaneously administered vaccine is highly effective in preventing severe influenza such as pneumonia, but has low antibody-inducing activity in the mucosa of the upper respiratory tract at the si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/145A61K9/12A61K47/32A61M11/00A61P31/16
CPCA61K47/32A61K9/12A61M11/007A61M2206/16A61K39/12A61K2039/5252A61K2039/543A61K2039/55505A61K2039/55511A61P31/16C12N2760/16134A61K39/145A61M11/06A61M11/00A61M11/001A61K47/02A61M2210/0618C12N7/00C12N2760/16034
Inventor 上下泰造宫崎隆
Owner TOKO YAKUHIN IND CO LTD
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