Folium artemisiae argyi effervescent tablet and preparation method thereof
The technology of effervescent tablet and mugwort leaf is applied in the field of mugwort effervescent tablet and its preparation, which can solve the problems such as the difficulty of dissolving active ingredients, and achieve the effects of preventing melanin deposition, delaying skin aging, and making the skin white and smooth.
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Embodiment 1
[0035] A kind of mugwort leaf effervescent tablet of the present invention, its raw material comprises by weight: 8 parts of mugwort leaf extract, 10 parts of jujube extract, 2 parts of wolfberry extract, 5 parts of honey, 6 parts of aspartame, 30 parts of sodium bicarbonate parts, 25 parts of citric acid, 6 parts of polyvinylpyrrolidone, and 2 parts of polyethylene glycol 6000.
[0036] The preparation method of described mugwort effervescent tablet, comprises the steps:
[0037] 1. Preparation of Folium Artemisiae Argyi Extract:
[0038] Grind an appropriate amount of dried Artemisia argyi leaves evenly with a pulverizer, use 70% ethanol-water as the extraction solvent, heat and reflux at 85°C for 1 hour to extract three times, each time for 2 hours, combine the extracts, discard the dregs, and evaporate the extracts under reduced pressure and rotary evaporation Concentrate to dryness to evaporate water, adopt the method of spray drying to obtain the extract powder of Artem...
Embodiment 2
[0048] Embodiment 2 Determination of relevant indexes of Artemisia argyi effervescent tablet
[0049] 1. Determination of disintegration time limit
[0050] Take 1 piece of Artemisia argyi effervescent tablet prepared in Example 1 and put it into a clean beaker filled with 200mL of water. The time during which the aggregated particles stay is the disintegration time of the effervescent tablet.
[0051] The results showed that the average disintegration time was 3.58min, all within 5min, and the relative standard deviation was 2.93%. 2. Determination of pH value
[0052] Take 1 piece of mugwort effervescent tablet, calculate the amount of water added according to the weight in the photo, put it in a beaker with water at 37°C, when the mugwort effervescent tablet is evenly dissolved in the water, no gas escapes, and no visible aggregated particles stay , to measure the pH of the solution.
[0053] As a result, the average pH value of the Artemisia argyi effervescent ta...
Embodiment 3
[0067] Example 3 In vitro antioxidation study of Artemisia argyi effervescent tablets
[0068] Determination of DPPH free radical inhibition rate
[0069] DPPH free radical has characteristic absorption in the visible light region. It is a kind of stable free radical synthesized by man-made. Oxidation properties.
[0070] Take different concentrations and different volumes of Artemisia argyi effervescent tablet solutions and dilute them to 3.0 mL with ethanol, then add 1.0 mL of 0.2 mmol / LDPPH ethanol solution, shake evenly, place in the dark for 30 min at room temperature, and measure the absorbance of the reaction solution at 517 nm. Take ethanol as a reference. Artemisia argyi effervescent tablet solution and ascorbic acid solution can calculate following formula to the inhibition rate of DPPH: inhibition rate (%)=(A 0 -A 样 ) / A 0 x100%, the results of the ability of scavenging DPPH free radicals of Artemisia argyi effervescent tablet sample liquid see figure 1 . ...
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