Kit for predicting recurrence and transference risk of patient suffering from early-stage operable esophageal squamous carcinoma

Abstract

The invention provides a kit for predicting recurrence and transference risk of a patient suffering from early-stage operable esophageal squamous carcinoma. The kit contains amplification primers of 32 genes of BCL2, Survivin, STAT3, cIAP1, cIAP2, beta-catenin, Cyclin D1, CDKN2A, TCF4, EGFR, HER-2, AREG, EREG, TFPI-2, WNT1, BMI-1, MTOR, ATM, ATR, XRCC1, XRCC2, XRCC3, XRCC4, XRCC5, HIF-1alpha, HIF-2alpha, VEGF, RAD51, beta-actin, GAPDH, GUS and TFRC in all. The kit is capable of accurately predicting transference potential of early-stage operable esophageal squamous carcinoma, so that the transference and recurrence risk of the patient suffering from the early-stage operable esophageal squamous carcinoma after radical operation can be accurately predicted and evaluated, patients with high risk can be particularly monitored and effectively interfered, recurrence and transference of esophageal squamous carcinoma can be reduced, and prognosis of the patients can be further improved.

Description

technical field [0001] The invention belongs to the technical field of medical detection reagents, and specifically relates to a kit for predicting the risk of recurrence and metastasis of patients with early operable esophageal squamous cell carcinoma and the application of amplification primers for 32 genes. Background technique [0002] Esophageal cancer is one of the most common malignant tumors in my country, and about 95% of them are squamous cell carcinomas. According to NCCN guidelines, the standard treatment for early esophageal squamous cell carcinoma (T1-2N0M0) is surgical resection. Although the 5-year survival rate after surgical treatment for early esophageal squamous cell carcinoma can reach more than 90%, some patients still have early lymph node metastasis and local recurrence, showing a poor prognosis. Therefore, to predict lymph node metastasis and recurrence in patients with early-stage esophageal squamous cell carcinoma. [0003] With the advancement o...

AI Technical Summary

Problems solved by technology

However, there are multiple groups of genes involved in the regulation of the biological characteristics of tumors. At present, most studies focus on single-factor research models, only exploring the correlation between one or a few genes and prognosis, which cannot fully reflect the accurate molecular biology of early esophageal squamous cell carcinoma. characteristics, it is difficult to reflect the complex transfer process

Therefore, there is no index at home and abroad that can be used clinically to predict and diagnose the metastasis and recurrence of early-stage esophageal squamous cell carcinoma.

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