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Desonide lotion with more stable quality

A technology for desonide lotion and neide lotion, applied in the field of desonide lotion and desonide preparation, can solve problems such as uneven content and obvious sedimentation of active ingredients, and achieve obvious improvement in sedimentation, uniform and stable content , the effect of good physical stability

Inactive Publication Date: 2017-03-08
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, one of the purposes of the present invention is to provide a stable matrix that improves the quality stability of desonide lotion, and the stable matrix can improve the obvious and uneven content of the active ingredient in the existing desonide lotion. Defects

Method used

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  • Desonide lotion with more stable quality
  • Desonide lotion with more stable quality
  • Desonide lotion with more stable quality

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The desonide lotion of this embodiment has the following composition:

[0034]

[0035]

[0036] Preparation:

[0037] 1) Aqueous phase preparation: Weigh the purified water, xanthan gum, glycerin, disodium edetate, phenoxyethanol, citric acid and sodium citrate, heat and stir at 80℃ to dissolve completely, keep warm , Add desonide, stir and disperse evenly at 40R / min;

[0038] 2) Preparation of oil phase: Weigh the prescription amount of Span 80, liquid paraffin and cetostearyl alcohol, heat and melt them completely at 80°C, and keep warm;

[0039] 3) Emulsification: Add the water phase to the oil phase at a temperature of 80°C, stir and emulsify for 10 minutes at 40R / min, and gradually lower the temperature to 40°C to obtain a lotion.

Embodiment 2

[0041] The desonide lotion of this embodiment has the following composition:

[0042]

[0043]

[0044] Preparation:

[0045] 1) Water phase preparation: Weigh half of the prescription amount of hot purified water (about 80℃), add hydroxyphenylmethyl cellulose and stir to disperse, then add half of the prescription amount of purified water and stir to dissolve; then add glycerin and ethylenediamine Disodium acetate, phenoxyethanol, citric acid and sodium citrate, heated and stirred at 80°C to dissolve completely, keep warm, add desonide, stir and disperse evenly at 40R / min;

[0046] 2) Preparation of oil phase: Weigh the prescription amount of Span 80, liquid paraffin and cetostearyl alcohol, heat and melt them completely at 80°C, and keep warm;

[0047] 3) Emulsification: Add the water phase to the oil phase at a temperature of 80°C, stir and emulsify for 10 minutes at 40R / min, and gradually lower the temperature to 40°C to obtain a lotion.

Embodiment 3

[0049] The desonide lotion of this embodiment has the following composition:

[0050]

[0051] Preparation:

[0052] 1) Aqueous phase preparation: Weigh the purified water, gum arabic, glycerin, disodium edetate, phenoxyethanol, citric acid and sodium citrate, heat and stir at 80℃ to dissolve completely, keep warm, add Desonide, 40R / min stirring and dispersing uniformly

[0053] 2) Preparation of oil phase: Weigh the prescription amount of Span 80, liquid paraffin and cetostearyl alcohol, heat and melt them completely at 80°C, and keep warm;

[0054] 3) Emulsification: Add the water phase to the oil phase at a temperature of 80°C, stir and emulsify for 10 minutes at 40R / min, and gradually lower the temperature to 40°C to obtain a lotion.

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Abstract

The invention relates to a desonide preparation, specifically to a desonide lotion with more stable quality, belonging to the field of medicinal preparations. The desonide lotion with more stable quality is a lotion containing a stable matrix which is one or more selected from a group consisting of a natural high polymer or a derivative thereof, a cellulose ether compound and a synthetic polymeric compound. The desonide lotion has good physical stability and chemical stability; the physical stability is embodied in that active components are suspended in the lotion and free of obvious settlement trend, and the desonide lotion has good content uniformity and does not need shaking in use, which greatly facilitates usage of the desonide lotion by patients, especially elder patients; and the chemical stability is embodied in that related substances in the lotion accord with control limits prescribed in guidance principles for related substances of chemical drugs, and components in the prescription of the desonide lotion pose no interference to a detection system for the related substances, which is better than commercially available products at present.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a desonide preparation, in particular to a desonide lotion with more stable quality. Background technique [0002] Desonide is a glucocorticoid drug that has anti-inflammatory, anti-allergic, antipruritic and reducing exudation effects; it can reduce and prevent tissue response to inflammation, and can eliminate fever, redness and redness caused by local non-infectious inflammation. Swelling, thereby reducing the manifestation of inflammation; has an immunosuppressive effect: prevent or inhibit cellular immune response, and inhibit the initial immune response. Desonide external preparations can be used for the treatment of various hormone-sensitive skin diseases such as contact dermatitis, neurodermatitis, seborrheic dermatitis, eczema, psoriasis, lichen planus, lichen simplex, hidrosis and pruritus Wait. [0003] Currently commercially available desonide lotion is developed b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/58A61K47/10A61K47/12A61P17/00A61P37/08
Inventor 陈李平管璐晗蒋海龙传娜赵静
Owner CHONGQING HUAPONT PHARMA
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