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Compositions of pentosan polysulfate salts for oral administration and methods of use

A technology of pentosan polysulfate sodium and composition, which is applied in the direction of drug combination, sugar derivatives, sugar derivatives, etc., and can solve the problems of high dose, low oral absorption of pentosan polysulfate, and affecting the urinary tract, etc.

Inactive Publication Date: 2017-02-22
URIGEN PHARMA INC +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tritiated pentosan polysulfate was used in this study and pentosan polysulfate was not directly measured, tritiated pentosan polysulfate is released spontaneously 3 h
The key point of this study is that the oral absorption of pentosan polysulfate is low
[0023] Therefore, due to the relatively poor bioavailability of pentosan polysulfate sodium, relatively large doses are required when using pentosan polysulfate sodium for oral administration in the treatment of interstitial cystitis and other diseases or conditions affecting the urinary tract
Such large dose requirements may lead to side effects

Method used

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  • Compositions of pentosan polysulfate salts for oral administration and methods of use
  • Compositions of pentosan polysulfate salts for oral administration and methods of use
  • Compositions of pentosan polysulfate salts for oral administration and methods of use

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Embodiment Construction

[0106] One aspect of the present invention is a pharmaceutical composition comprising:

[0107] (1) A therapeutically effective amount of pentosan polysulfate;

[0108] (2) A certain amount of penetration enhancer is used to improve the bioavailability of pentosan polysulfate; and

[0109] (3) Optionally, at least one filler, excipient or carrier.

[0110] Pentosan polysulfate (PPS) is a semi-synthetic polysulfated oligosaccharide comprising a mixture of multi-charged anionic polysaccharides. PPS is prepared from woody plants such as beech trees by chemical sulfation of polysaccharides such as xylan. The resulting product usually contains about 15-17% sulfur in the form of about 1.5-1.9 covalently bound sulfuric acid groups per sugar residue in a mixture of polydisperse polymer molecules, and is estimated to have about 4000 to about 10,000 Daltons. The molecular weight. PPS is composed of sulfated linear polysaccharides of about 12 to 30 1-4 conjugated β-D-xylopyranose units (Mr=~4...

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Abstract

The present invention is directed to a pharmaceutical composition comprising: (1 ) a therapeutically effective quantity of sodium pentosan polysulfate; (2) a quantity of a penetration enhancer sufficient to improve the bioavailability of the sodium pentosan polysulfate; and (3) optionally, a pharmaceutically acceptable carrier and to methods for the oral administration of sodium pentosan polysulfate with improved bioavailability for the treatment of interstitial cystitis and other urinary tract diseases and conditions. Such compositions and methods allow the administration of sodium pentosan polysulfate at lower dosages to reduce the frequency and severity of side effects.

Description

[0001] Cross-reference related applications [0002] This application requires the rights of the U.S. Provisional Application Serial No. 61 / 943824 filed on February 24, 2014. The applicants are Dr. C. Lowell Parsons, Dr. Michael Gorberg and Christopher P. Minan, applying The name is "Composition using oral administration of sodium pentosan polysulfate and other pentosan polysulfate salts and methods for treating diseases and disorders", the entire content of which is incorporated into this application by reference. Technical field [0003] The present invention relates to a composition of pentosan polysulfate sodium for oral administration and a method for treating a series of diseases and disorders, including interstitial cystitis and other urinary tract diseases and disorders, such as, but not limited to, kidney stones , Radiation cystitis, prostatitis, overactive bladder and urinary system infections, and other diseases and conditions, including but not limited to: HIV infection...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715C07H5/10A61K47/14A61P19/02
CPCA61K31/715A61K45/06A61K31/20A61K31/737A61P13/02A61P13/08A61P13/10A61P13/12A61P19/00A61P19/02A61P25/00A61P25/28A61P29/00A61P31/18A61P35/00A61P37/02A61P9/00A61P9/10Y02A50/30A61K2300/00A61K31/166A61K9/006A61K47/00
Inventor C·洛厄尔·帕森斯迈克尔·高伯格克里斯托弗·P·米南
Owner URIGEN PHARMA INC
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