Penicillin bottle handling method, penicillin bottle obtained through handling, and penicillin-bottled water for injection

Abstract

The invention provides a penicillin bottle handling method, a penicillin bottle obtained through handling, and penicillin-bottled water for injection, and belongs to the technical field of medicine. The penicillin bottle comprises a bottle body and a butyl rubber plug. The penicillin bottle handling method comprises the following steps in any sequence: (1) handling the bottle body by utilizing an acid solution and an alkaline solution sequentially, carrying out cleaning till the pH value reaches 5.0-7.0, and carrying out drying and sterilization for standby application; and (2) handling the butyl rubber plug by utilizing the acid solution, the alkaline solution and warm water sequentially, carrying out cleaning till the pH value reaches 5.0-7.0, and carrying out sterilization for standby application. The invention further provides a preparation method of the penicillin-bottled water for injection. The preparation method comprises the following step: filling the penicillin bottle obtained through handling with the water for injection. The water or liquid medicine for injection accommodated in the penicillin bottle obtained according to the penicillin bottle handling method, or the penicillin-bottled water or liquid medicine for injection obtained according to the preparation method not only is qualified and high in stability, but also can be protected from chloride leakage, chloride out-of-specification and the like after standing for a long time, and is suitable for long-term preservation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for preparing vial-packed water for injection. Background technique [0002] In the field of medicine, water for injection and liquid medicine for injection are often contained in ampoules. [0003] Ampoule (ampoule / ampule) is a kind of small glass container, and the capacity is generally 1~25ml. In the past, ampoules were also used for the packaging of oral liquids, but they are no longer popular due to the difficulty of opening and accidents for consumers. [0004] Modern ampoules are fired in glass tubes and are widely used to contain injection preparations and high-purity chemicals that must be isolated from air. The nipple of the ampoule is sealed with an open flame to insulate the air, and the neck of the bottle is marked. When pressure is applied, the neck of the bottle will snap off so that the liquid medicine can be extracted. Some ampoules use a...

AI Technical Summary

Problems solved by technology

[0006] (1) Defective ampoules or mishandling can cause the nipple or even the bottle to be broken when the ampoule is opened, resulting in injury to medical staff and possible pollution caused by glass fragments falling into the liquid medicine

[0007] (2) Particles in the glass and grinding wheel during the opening of the ampoule will cause contamination of the liquid medicine

[0008] (3) When the straight-neck ampoule is broken by a nurse, many invisible glass fragments will fall into the medicine, causing platelet rupture in the recipient. Once particles enter the heart with the blood, it may even cause death

[0010] Existing some prior art at present, is to contain various injection liquids in vials, for example: cefepime hydrochloride for injection, aztreonam for injection, ropivacaine mesylate injection etc., and their preparation process , but, the preparation method of packing water for injection into vials is still blank in the art

However, in clinical practice, the use of water for injection is more frequent than that of liquid medicine for injection, and the amount of use is also larger. Therefore, there is an urgent need to establish a preparation process for bottled water for injection in this field.

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