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A kind of injectable calcium phosphate/natural polymer composite material and its preparation method and application

A technology of natural polymers and composite materials, applied in the field of biomedical materials, can solve the problems of restoring the original state, producing granulomas, and being difficult to remove within 5-1 years, achieving the effect of good clinical application prospects and good shaping effect.

Active Publication Date: 2019-11-15
成都睿漾再生医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Non-degradable biomaterials have some potential risks, such as foreign body granuloma, material displacement, etc., and it is not easy to take out when there is a problem, which will bring great harm to patients; degradable biomaterials have higher biological safety, However, the absorption is fast and the maintenance time is short. Generally, it returns to its original state within 0.5-1 year, and it is difficult to maintain the plastic effect for a long time. The composite biomaterial can moderately prolong the maintenance time, which is a good choice in clinical practice, but there are still some problems, such as granulation. swelling etc.
[0005] With the increasing application of the above-mentioned filling materials, their shortcomings are exposed. Some tissue reactions are severe, and some degrade quickly, which is far from achieving the desired effect.

Method used

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  • A kind of injectable calcium phosphate/natural polymer composite material and its preparation method and application
  • A kind of injectable calcium phosphate/natural polymer composite material and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1 Preparation of injectable calcium phosphate / sodium hyaluronate composite material of the present invention

[0026] 1. Preparation method

[0027] 1) Prepared with sodium hyaluronate (molecular weight 1000kDa, Shandong Huaxi Freda Biomedical Co., Ltd.) modified by 1,4-butanediol glycidyl ether (BDDE) (modification degree 6-10%) into 10ml of 2.5% aqueous solution;

[0028] 2) Take 15g of hydroxyapatite ceramic particles with a particle size of 70-100 μm, add them to the above-mentioned sodium hyaluronate solution and stir evenly to form a paste compound (the solid content of the calcium phosphate ceramic particles is 60 (w / w)%, The solid content of sodium hyaluronate is 1.0 (w / w)%);

[0029] Preparation of hydroxyapatite ceramic particles with a particle size of 70-100 μm: disperse hydroxyapatite micropowder into 1.5% polyvinyl alcohol aqueous solution, transfer to a ball mill and mill for 24 hours to form a slurry with good particle dispersibility. The p...

Embodiment 2

[0031] Embodiment 2 Preparation of injectable calcium phosphate / collagen composite material of the present invention

[0032] 1. Preparation method

[0033] 1) Take medical collagen and prepare 10ml of 1.0% aqueous solution;

[0034] 2) Take 30g of biphasic calcium phosphate ceramic particles (hydroxyapatite / tricalcium phosphate=70 / 30) with a particle size of 40-70 μm, add them to the above collagen solution and stir evenly to form a paste-like composite (calcium phosphate ceramic The solid content of the particles is 75 (w / w)%, and the solid content of the collagen is 0.25 (w / w)%);

[0035] Preparation of biphasic calcium phosphate ceramic particles with a particle size of 40-70 μm: Disperse the biphasic calcium phosphate micropowder into a 1.0% polyvinyl alcohol aqueous solution, transfer to a ball mill and mill for 24 hours to form a slurry with good particle dispersion, through peristaltic The pump is transported to the spray dryer for spray drying treatment, the spray d...

Embodiment 3

[0037] Example 3 Preparation of injectable calcium phosphate / sodium hyaluronate-chondroitin sulfate composite material of the present invention

[0038] 1. Preparation method

[0039] 1) Take sodium hyaluronate (molecular weight 500kDa, Shandong Huaxi Freda Biomedicine Co., Ltd.) and chondroitin sulfate (Shanghai Aladdin Reagent Company) to prepare 10ml of 1.5% sodium hyaluronate and 0.5% chondroitin sulfate Mixed aqueous solution;

[0040] 2) Take 30g of hydroxyapatite ceramic particles containing 5% bioactive glass (45S5 bioglass, Kunshan Huaqiao Technology New Material Co., Ltd.) with a particle size of 20-40 μm, and add it to the above-mentioned sodium hyaluronate-chondroitin sulfate mixture Stir evenly in the solution to form a paste compound (the solid content of calcium phosphate ceramic particles is 75 (w / w)%, and the solid content of sodium hyaluronate and chondroitin sulfate is 0.5 (w / w)%);

[0041] Preparation of hydroxyapatite ceramic particles containing 5% bioa...

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Abstract

The invention discloses an injectable calcium phosphate / natural polymer composite material. The injectable calcium phosphate / natural polymer composite material is an injectable paste material formed by uniformly dispersing approximately spherical calcium phosphate ceramic particles with the particle size of 20-100 microns in a natural polymer (or its derivative) solution, wherein calcium phosphate is hydroxyapatite or diphasic calcium phosphate, 0-20% of bioactive glass can be added, the natural polymer or its derivative is one or more of sodium hyaluronate, collagen, chitosan, chondroitin sulfate and the like. The invention further discloses a preparation method of an injectable calcium phosphate / natural polymer composite material and a method for performing facial mini-plastic surgery by adopting the method. After the injectable calcium phosphate / natural polymer composite material is implanted in a body by adopting the method, a natural polymer in the material is degraded and absorbed, the calcium phosphate ceramic particles are fused with an autologous bone tissue together, a lasting shaping effect can be achieved, and clinical application prospect is good.

Description

technical field [0001] The invention relates to an injectable calcium phosphate / natural polymer composite material and its preparation method and application, belonging to the field of biomedical materials. Background technique [0002] According to statistics, there are more than 1 million new patients with craniofacial soft and hard tissue deformities or defects caused by congenital malformations, tumor resections, and traffic accidents worldwide every year, and the number of people who need facial plastic surgery cannot be counted. [0003] Since liquid paraffin was first used clinically as a skin and soft tissue filler in 1899, scholars from all over the world have conducted in-depth research on injection filling materials and their clinical applications, and have made many progresses. More and more injection fillers are widely used. In the fields of cosmetic dermatology and plastic surgery, in order to correct human body shape defects and deformities through injection. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/54A61L27/50A61L27/24A61L27/20A61L27/12A61L27/10
CPCA61L27/10A61L27/12A61L27/20A61L27/24A61L27/50A61L27/54A61L27/58A61L2400/06C08L89/06C08L5/08
Inventor 朱向东刘燕林海肖玉梅樊渝江张兴栋
Owner 成都睿漾再生医疗科技有限公司
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