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Aerosol inhalation preparation for treating bronchial asthma

A technology for bronchial asthma and atomization inhalation, applied in the field of medicine

Inactive Publication Date: 2017-01-25
HANGZHOU BIO SINCERITY PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The present invention mainly solves the problems in the prior art and develops a preparation for treating bronchial asthma that can be stored stably and is suitable for nebulized inhalation

Method used

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  • Aerosol inhalation preparation for treating bronchial asthma
  • Aerosol inhalation preparation for treating bronchial asthma
  • Aerosol inhalation preparation for treating bronchial asthma

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Doxofylline 1.0g tartaric acid 0.1g potassium chloride 0.7g sodium hydroxide Appropriate amount (adjust pH to 6.0) Add purified water to 100ml

[0029] Process: under heating, add all the above ingredients except sodium hydroxide and dissolve in pure water, adjust the pH of the solution to 6.0 with sodium hydroxide, filter the obtained solution through a sterile filter, and then fill the filtered medicinal solution in In 2-5ml ampoules, sterilize by high-pressure steam at 121°C for 15 minutes to obtain the doxofylline atomized inhalation preparation.

Embodiment 2

[0031] Doxofylline 1.0g Edetate disodium 0.05g Sodium chloride 0.9g sodium hydroxide Appropriate amount (adjust pH to 5.0) Add purified water to 100ml

[0032] Process: In the case of heating, add all the above ingredients except sodium hydroxide to dissolve in pure water, adjust the pH of the solution to 5.0 with sodium hydroxide, filter the obtained solution through a sterile filter, and then fill the filtered medicinal solution in In 2-5ml low borosilicate ampoule bottle, doxofylline atomized inhalation solution is obtained through aseptic treatment.

Embodiment 3

[0034] Doxofylline 1.0g Edetate disodium 0.1g Sodium chloride 0.7g sodium hydroxide Appropriate amount (adjust pH to 5.8) Add purified water to 100ml

[0035] Process: under heating, add all the above ingredients except sodium hydroxide and dissolve in pure water, adjust the pH of the solution to 5.8 with sodium hydroxide, filter the obtained solution through a sterile filter, and then fill the filtered medicinal solution in 2-5ml low-density polyethylene ampoule bottle, through aseptic treatment, the doxofylline atomized inhalation preparation is obtained.

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Abstract

The invention relates to an aerosol inhalation preparation for treating bronchial asthma. The aerosol inhalation preparation contains doxofylline taken as an active substance, a solvent, a stabilizer and / or a pharmacologically acceptable carrier. According to the doxofylline aerosol inhalation preparation made from the components at specific ratio provided by the invention, the character, PH, insoluble particle, content, related substance and osmotic pressure are not obviously changed after 0-month acceleration, so that the doxofylline aerosol inhalation preparation by the invention is higher in stability. Meanwhile, the doxofylline aerosol inhalation solution has excellent atomization effect and high absorptivity and the effective dose below 5mu m reaches up to 50% or above.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to an atomized inhalation preparation, in particular to an atomized inhalation preparation for treating bronchial asthma. Background technique [0002] The purpose of using medicinal inhalants is to treat respiratory and pulmonary diseases and systemic diseases, and the drug must be delivered to the action site or absorption site to work. The rate of drug absorption in the lungs is directly proportional to the fat solubility of the drug, and inversely proportional to the molecular weight of the drug. When inhaled, not all the atomized particles can reach the main absorption site - the alveoli. For local effects on the lungs, it is generally believed that the size of the particles is 3-10 μm; however, for rapid absorption and systemic effects, the particle size should be as small as 0.5-5 μm. When bronchodilator drugs are administered by inhalation, if they contain a large number of lar...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K31/522A61P11/06
CPCA61K9/0078A61K9/08A61K31/522A61K47/12A61K47/183
Inventor 凌敏燕刘保林楼金芳陆慧张冯敏
Owner HANGZHOU BIO SINCERITY PHARMA TECH CO LTD
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