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Bisphenol A imprinted Pickering emulsion polymer microspheres, preparation and applications thereof

A Pickering emulsion and polymer technology, applied in the fields of biological analysis and new materials, to achieve high adsorption capacity and selectivity, reduce matrix interference, and ultra-high specific selectivity

Inactive Publication Date: 2017-01-04
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report on the preparation of polymer microspheres for imprinting bisphenols by Pickering emulsion polymerization

Method used

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  • Bisphenol A imprinted Pickering emulsion polymer microspheres, preparation and applications thereof
  • Bisphenol A imprinted Pickering emulsion polymer microspheres, preparation and applications thereof
  • Bisphenol A imprinted Pickering emulsion polymer microspheres, preparation and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of bisphenol A imprinted Pickering emulsion polymer microspheres and their corresponding non-imprinted Pickering emulsion polymer microspheres for selective separation and purification of bisphenol pollutants:

[0033] (1) 0.228g (1mmol) template molecule bisphenol A (BPA), 0.42mL (4mmol) functional monomer 4-vinylpyridine (4-VP), 3.8mL (20mmol) cross-linking agent dimethacrylate Glycol ester (EGDMA) and 40mg initiator azobisisobutyronitrile (AIBN) were dissolved in 3.6mL of porogen toluene, 100Hz ultrasonic 5min to make it evenly mixed to form a pre-polymerization solution, and nitrogen gas was passed through for 10min to remove oxygen for backup use.

[0034] (2) 30mg of SiO 2 Nanoparticles were dispersed in 10 mL of Triton X-100 aqueous solution with a mass concentration of 0.2% by ultrasonication at 100 Hz for 10 min. Then add 4 mL of the pre-polymerization solution obtained in step (1), shake it by hand for 1.0 min to form a stable Pickering emulsion,...

Embodiment 2

[0039] Static adsorption evaluation is carried out to the material prepared by the method provided by the invention:

[0040] Accurately configure acetonitrile of BPA with a series of concentrations (0.02mmol / L, 0.05mmol / L, 0.1mmol / L, 0.2mmol / L, 0.5mmol / L, 1.0mmol / L, 2.0mmol / L, 4.0mmol / L) The solution is ready for use. Take 2ml of each of the above solutions and place them in separate sample bottles, add 40 mg of bisphenol A imprinted Pickering emulsion polymer microspheres prepared in Example 1 to each sample bottle, and take BPA of serial concentrations configured in addition. Each 2ml of the acetonitrile solution was placed in a separate sample bottle, and 40 mg of the non-imprinted Pickering emulsion polymer microspheres prepared in Example 1 were added to each sample bottle. After continuous shaking at a speed of 150 rpm for 24 hours, the solid-liquid mixture was filtered with a 0.22 μm filter membrane. Utilize Agilent 1200 type high performance liquid chromatography to ...

Embodiment 3

[0043] Evaluate the imprint factor of bisphenol A imprinted Pickering emulsion polymer microspheres prepared by the method provided by the invention to bisphenol pollutants:

[0044] The bisphenol pollutants include: bisphenol A (BPA), bisphenol F (BPF), bisphenol B (BPB), bisphenol E (BPE), bisphenol AF (BPAF), bisphenol S (BPS) , bisphenol AP (BPAP), bisphenol Z (BPZ), tetrabromobisphenol A (TBBPA), estrone (E1), 17β-estradiol (E2), dienestrol (DNS), diethylstilbestrol ( DES), n-octylphenol (OP) and n-nonylphenol (NP).

[0045] The bisphenol A imprinted Pickering emulsion polymer microspheres prepared in Example 1 and the corresponding non-imprinted Pickering emulsion polymer microspheres were packed into stainless steel chromatographic columns (100mm × 4.6mm) with methanol as the dispersion solvent. i.d.), resulting in imprinted and non-imprinted columns. The retention time of the above-mentioned bisphenol pollutants on the imprinted column and non-imprinted column was ob...

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Abstract

The invention provides bisphenol A imprinted Pickering emulsion polymer microspheres, preparation and applications thereof. The preparation method comprises: dissolving a template molecule bisphenol A (BPA), a functional monomer 4-vinylpyridine (4-VP), a cross-linking agent ethyleneglycol dimethacrylate (EGDMA) and an initiator azobisisobutyronitrile (AIBN) in a pore forming agent toluene, introducing high-purity nitrogen gas to remove oxygen gas, dispersing SiO2 nanoparticles in an aqueous solution of Triton X-100, mixing the two obtained solutions, violently vibrating, introducing nitrogen gas to remove oxygen gas, sealing, polymerizing for 16 h at a temperature of 70 DEG C, removing the SiO2 on the surface of the obtained SiO2-polymer composite material through hydrofluoric acid, and removing the template molecule bisphenol A (BPA) through Soxhlet extraction so as to complete the preparation of the BPA imprinted Pickering emulsion polymer microspheres. According to the present invention, the molecular imprinting polymer microspheres have good adsorption capacity for BPA, provide good selectivity to BPA and structural analogues thereof, and show good type selectivity and good purification capacity when the molecular imprinting polymer microspheres adopted as the solid phase extraction filler are applied in the selective separation experiments of the eight bisphenol substances in the human urine sample.

Description

technical field [0001] The invention relates to the preparation and application of bisphenol A imprinted Pickering emulsion polymer microspheres for selectively separating and purifying bisphenol A and its structural analogues, belonging to the fields of biological analysis and new materials. Background technique [0002] Bisphenol A is recognized as an endocrine disrupting chemical (EDC), and its harm to human reproduction and development, nervous system, cardiovascular system, metabolism and immune system has been widely confirmed. In view of this situation, the U.S. Environmental Protection Agency (USEPA) and the European Food Safety Authority (EFSA) have stipulated the reference value of the maximum daily intake of bisphenol A, and Health Canada has also done related work. The European Union has imposed strict restrictions on the migration of bisphenol A from plastic products used in food production. In response to these restrictions and regulations, many manufacturers ...

Claims

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Application Information

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IPC IPC(8): C08F222/14C08F226/06C08K3/36C08J9/28B01J20/26B01J20/28B01J20/30B01D15/08
Inventor 陈吉平杨甲甲李云王龙星
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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