Production process of high-quality phenylacetic acid

A production process, a technology of phenylacetic acid, applied in the directions of carboxylate preparation, carboxylate preparation, organic chemistry, etc., can solve the problems of the treatment process without fundamentally removing impurities, complex process, low production efficiency, etc., and achieve convenient Post-processing process, good continuity, and the effect of improving quality

Active Publication Date: 2017-01-04
HEBEI CHENGXIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The quality of phenylacetic acid obtained by this process is high, but the process is more complicated and it is not easy to achieve continuous
[0011] The above-mentioned purification method removes impurities to a certain extent, but there are the following problems: the impurities are not fundamentally removed or the treatment process is complicated, it is difficult to realize continuous operation, and the production efficiency is low

Method used

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  • Production process of high-quality phenylacetic acid
  • Production process of high-quality phenylacetic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] (1) Add a 30% mass concentration sodium hydroxide aqueous solution to a 5000L enamel reaction kettle, and then add a certain amount of water to dilute the 30% mass concentration sodium hydroxide aqueous solution to 3280kg of a 15% mass concentration dilute lye. Then, start warming to reflux. Open the discharge valve of the benzyl nitrile metering tank, adjust the adding speed of 1200kg benzyl nitrile, and complete the addition in about 3 hours. During the dropwise addition, ammonia gas is released all the time, so it is necessary to ensure that the ammonia gas is discharged smoothly. After the dropwise addition was completed, the mixture was kept warm for 2 hours. The temperature was lowered to obtain an aqueous solution of sodium phenylacetate, and the pH of the aqueous solution of sodium phenylacetate was adjusted to 6.

[0047] (2) In the continuous extraction tower, pump the pH-adjusted sodium phenylacetate aqueous solution from the upper inlet, and pump the extrac...

Embodiment 2

[0052](1) Add a 30% mass concentration sodium hydroxide aqueous solution to a 5000L enamel reaction kettle, and then add a certain amount of water to dilute the 30% mass concentration sodium hydroxide aqueous solution to 3280kg of a 15% mass concentration dilute lye. Then, start warming to reflux. Open the discharge valve of benzyl nitrile metering tank, adjust the adding speed of 1200kg benzyl nitrile, finish adding in 3 hours, in the process of dropping, ammonia gas is released all the time, guarantee that ammonia gas is discharged unobstructed. After the dropwise addition is completed, keep warm for 2 hours. The temperature was lowered to obtain an aqueous solution of sodium phenylacetate. Adjust the pH of the sodium phenylacetate aqueous solution to 8.

[0053] (2) In the continuous extraction tower, the sodium phenylacetate aqueous solution after pH adjustment is pumped from the upper inlet, and the extractant isopropyl ether is pumped from the lower inlet. 35%, the ex...

Embodiment 3

[0058] (1) Add a 30% mass concentration sodium hydroxide aqueous solution to a 5000L enamel reaction kettle, and then add a certain amount of water to dilute the 30% mass concentration sodium hydroxide aqueous solution to 3280kg of a 15% mass concentration dilute lye. Then, start warming to reflux. Open the discharge valve of benzyl nitrile metering tank, adjust the adding speed of 1200kg benzyl nitrile, finish adding in 3 hours, in the process of dropping, ammonia gas is released all the time, guarantee that ammonia gas is discharged unobstructed. After the dropwise addition is completed, keep warm for 2 hours. The temperature was lowered to obtain an aqueous solution of sodium phenylacetate. Adjust the pH of the sodium phenylacetate aqueous solution to 8.

[0059] (2) In the continuous extraction tower, pump the pH adjusted sodium phenylacetate aqueous solution from the upper inlet, and pump the extractant toluene from the lower inlet. The amount of toluene is 40% of the p...

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Abstract

The invention discloses a production process of high-quality phenylacetic acid, and relates to the technical field of phenylacetic acid production. The production process includes the following steps that 1, benzyl cyanide is added dropwise into a water solution of sodium hydroxide or potassium hydroxide in a reflux state, a water solution of sodium phenylacetate or potassium phenylacetate is obtained through heat preservation, and the pH is adjusted to be 6-8; 2, extraction and impurity removal are carried out, wherein an extraction agent used in extraction is one or more of benzene, alkyl halide and ether organic solvent; 3, the water solution of sodium phenylacetate or potassium phenylacetate obtained after extraction enters an inlet in the upper portion of a desorber, and nitrogen is blown into an inlet in the lower portion of the desorber to desorb and separate the contained organic solvent; 4, activated carbon is used for adsorbing the water solution of sodium phenylacetate or potassium phenylacetate obtained after desorption; 5, water solution of sodium phenylacetate or potassium phenylacetate obtained after adsorption is acidized to obtain high-quality phenylacetic acid. The process can effectively increase the phenylacetic acid content and achieve continuous operation and is high in yield.

Description

technical field [0001] The invention relates to the technical field of production of phenylacetic acid. Background technique [0002] Phenylacetic acid is an important organic chemical raw material. It is mainly used in the production of penicillin, dimethazole and other drugs in the pharmaceutical industry; phenylacetic acid is chlorinated and esterified to obtain ethyl chlorophenylacetate, which is used for broad-spectrum organophosphorus The production of insecticides Daofengsan and Ethyl Daofengsan itself is also a pesticide plant growth stimulant; phenylacetic acid has a sweet honey taste at low concentrations, and phenylacetic acid and its esters are widely used as fixatives or modifiers. For the fragrance industry. [0003] The production process of phenylacetic acid mainly includes the acid hydrolysis method of benzyl nitrile, the alkaline hydrolysis method of benzyl nitrile, the styrene method, the carbonylation method of benzyl chloride, the acetophenone method, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/02C07C57/32
CPCC07C51/02C07C51/41C07C57/32
Inventor 贾荣荣张艳章李燕杨晓林程真真张林杰冯亚慧刘旭李静程丽华张辰亮
Owner HEBEI CHENGXIN
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