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Penicillin V potassium tablets and preparation technology thereof

A technology for the preparation of penicillin V, which is applied in the field of medicine, can solve the problems of greater interference in the quality inspection of penicillin V potassium tablets and increased costs, and achieve the effects of reducing the types of excipients, saving production costs, and improving stability

Active Publication Date: 2016-12-07
SHANXI GOODDOCTOR PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many types of excipients and their dosages in penicillin V potassium tablets on the market, resulting in increased costs. The more types of excipients, the greater the interference with the quality inspection of penicillin V potassium tablets. Therefore, it is urgent to screen out an excipient containing excipients. There are few types of prescription technology that can ensure the stability of penicillin V potassium tablets at the same time

Method used

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  • Penicillin V potassium tablets and preparation technology thereof
  • Penicillin V potassium tablets and preparation technology thereof
  • Penicillin V potassium tablets and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Feeding amount is shown in Table 1 (unit: kg)

[0041]

[0042] Prepare penicillin V potassium tablets according to the following preparation method from prescription 1 to prescription 6

[0043] Preparation Process:

[0044] (1) Preparation of adhesive: according to the weight ratio of povidone K30 and purified water is 11:28, add the povidone K30 of prescription quantity into purified water, stir while adding, place until it is completely dissolved, Pass through 120 mesh sieve;

[0045] (2) Granulation: Add penicillin V potassium into the tank mixer, mix for 2 minutes, add the adhesive, and stir for 3 minutes to make a soft material that can be held in a ball and disperse when lightly pressed. Granulate in a swinging granulator with a 22-mesh nylon screen to obtain wet granules;

[0046] (3) Drying: Pour the wet granules into a boiling dryer for drying at a temperature of 45°C for 35 minutes, and when the moisture content of the granules is controlled below 2.0%...

Embodiment 2

[0052] The dosage is as shown in prescriptions 1 to 6 in Table 1, and penicillin V potassium tablets were prepared according to the following preparation method.

[0053] (1) Preparation of adhesive: according to the weight ratio of povidone K30 and purified water is 11:18, add the povidone K30 of the prescription amount into purified water, stir while adding, place until it is completely dissolved, Pass through 100 mesh sieve;

[0054] (2) Granulation: Add penicillin V potassium into the tank mixer, mix for 1 minute, add binder, and stir for 2 minutes to make a soft material that can be held into a ball and disperse when lightly pressed. Granulate in a swinging granulator with a 22-mesh nylon screen to obtain wet granules;

[0055] (3) Drying: Pour the wet granules into a boiling dryer for drying at a temperature of 35°C for 60 minutes, and when the moisture content of the granules is controlled below 2.0%, dry granules are obtained;

[0056] (4) Grain sizing: the dry granule...

Embodiment 3

[0061] The dosage is as shown in prescription 1 to prescription 6 in Table 1, and penicillin V potassium tablets were prepared according to the following preparation method.

[0062] (1) Preparation of adhesive: according to the weight ratio of povidone K30 and purified water is 11:30, add the povidone K30 of the prescription amount into purified water, stir while adding, place until it is completely dissolved, Pass through 120 mesh sieve;

[0063] (2) Granulation: Add penicillin V potassium into the tank mixer, mix for 3 minutes, add binder, and stir for 3 minutes to make a soft material that is hand-held and lightly pressed to disperse. Granulate in a swinging granulator with a 22-mesh nylon screen to obtain wet granules;

[0064] (3) Drying: Pour the wet granules into a boiling dryer for drying at a temperature of 40°C for 40 minutes, and when the moisture content of the granules is controlled below 2.0%, dry granules are obtained;

[0065] (4) Grain sizing: the dry granu...

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Abstract

The invention provides penicillin V potassium tablets and a preparation technology thereof. The penicillin V potassium tablets are prepared from, by weight, 267 parts of penicillin V potassium, 8-10 parts of povidone, 3-5 parts of talc powder and 2-4 parts of magnesium stearate. The preparation technology comprises the steps of granulating of penicillin V potassium through the povindone solution, drying, grain size stabilizing, total blending, tabletting and film coating. According to the penicillin V potassium tablets, the stability is good, the disintegration time meets the specification, and little effective substance content is decreased in the expiry date; the production cost and interference on detection are reduced while the variety and dosage of auxiliary materials are reduced. The penicillin V potassium tablets obtained through the preparation method have the advantages that the tablets are not burst, a small tablet weight difference is generated, and no sticking occurs in the tabletting process.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a penicillin V potassium tablet and a preparation process thereof. Background technique [0002] Penicillin V potassium is suitable for mild and moderate infections caused by penicillin-sensitive strains, including tonsillitis, pharyngitis, scarlet fever, erysipelas, etc. caused by streptococcus; bronchitis, otitis media, and sinusitis caused by Streptococcus pneumoniae; and penicillin Skin and soft tissue infections caused by sensitive staphylococci. Penicillin V potassium can also be used as a preventive drug for recurrent rheumatic fever and infective endocarditis, and can also be used for spirochete infection. [0003] The application number is 201410137140.3, which discloses a penicillin V potassium tablet and its preparation method, wherein the composition of the penicillin V potassium tablet is "penicillin V potassium 30%-40%, compressible starch 55%-65%, seaweed Sodium Acetate 0...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K47/32A61K47/12A61K47/02A61P31/04
CPCA61K9/2009A61K9/2013A61K9/2027A61K9/2095A61K9/284A61K9/2893A61K31/43
Inventor 耿福能沈咏梅刘越飞
Owner SHANXI GOODDOCTOR PHARMA CO LTD
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