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Pressure-proof lycopene microcapsule and preparation method thereof

A lycopene and microcapsule technology, applied in the field of carotenoid microcapsules, can solve the problems of reduced core material protection, poor mechanical strength, not considering the quality requirements of tableting products, etc., so as to reduce voids and improve mechanical strength. and stability effects

Active Publication Date: 2016-11-09
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent uses spray drying to prepare powder, the particle size is small, the mechanical strength is poor, and the tablet is easy to leak the core material and reduce the stability.
2) 201410806201 (CN104431690A) relates to a lycopene microcapsule particle and its preparation process, which uses lycopene crystal powder, sunflower oil or corn oil, porous starch, oxidized starch, tapioca modified starch, corn syrup, seaweed Sugar and natural VE oil are used as the main raw materials to prepare microcapsule particles. The defect of this process is that the product quality requirements for tableting are not considered, the mechanical strength is poor, and the microcapsules are easily broken after tableting, which reduces the protective effect on the core material. Seriously affect its storage time

Method used

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  • Pressure-proof lycopene microcapsule and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Add 24g of gum arabic, 36g of gelatin, 100g of sucrose, 1.0g of polysorbate-80, 2.5g of sodium ascorbate and 2.5g of tea polyphenols into 200g of purified water, stir at 80°C for 30 minutes until completely dissolved, then add 2g of natural vitamins E, continue to stir and disperse evenly to obtain an aqueous phase.

[0026] 2. Add 20g of lycopene crystals with a content of 90% into the high-speed shearing water phase, the shearing speed is 10000r / min, the emulsification time is 30 minutes, and then pass through the high-pressure homogenizer twice, with a low pressure of 5MPa and a high pressure of 60MPa.

[0027] 3. Add the emulsion to the feed temporary storage tank, evacuate to 0.09MPa, and stir for 45 minutes.

[0028] 4. One-step granulation of the emulsion by spray-starch fluidized bed drying method, the conditions are: air inlet temperature 45°C, starch fluidized bed blast temperature 65°C, to obtain lycopene microcapsules with a particle size of 40-100 mesh ...

Embodiment 2

[0031] 1. Add 233.3g gum arabic, 466.7g gelatin, 900g glucose, 20g sucrose fatty acid ester, 10g sodium ascorbate and 10g tea polyphenol into 2200g purified water, stir at 65°C for 30 minutes until completely dissolved, then add 40g rosemary to extract matter, continue stirring to disperse evenly, and obtain an aqueous phase.

[0032] 2. Add 200g of lycopene crystals with a content of 90% to the high-speed shearing water phase, the shearing speed is 12000r / min, the emulsification time is 40 minutes, and then pass through the high-pressure homogenizer twice, with a low pressure of 5MPa and a high pressure of 75MPa.

[0033] 3. Add the emulsion into the feed temporary storage tank, evacuate to 0.095MPa, and stir for 30 minutes.

[0034] 4. One-step granulation of the emulsion by spray-starch fluidized bed drying method, the conditions are: air inlet temperature 40°C, starch fluidized bed blast temperature 75°C, to obtain lycopene microcapsules with a particle size of 40-100 mesh...

Embodiment 3

[0037] 1. Add 20kg of gum arabic, 40kg of gelatin, 60kg of isomaltooligosaccharide, 1.2kg of polyglycerol fatty acid ester, 1.27kg of sodium ascorbate and 1.28kg of tea polyphenol into 180kg of purified water, stir at 70°C for 1 hour until completely dissolved, then add 2.25kg of the mixture of natural vitamin E and rosemary extract etc., continue to stir and disperse evenly to obtain the water phase.

[0038] 2. Add 15kg of lycopene crystals with a content of 90% to the high-speed shearing water phase, the shearing speed is 13000r / min, the emulsification time is 45 minutes, and then pass through the high-pressure homogenizer 3 times, with a low pressure of 10MPa and a high pressure of 70MPa.

[0039] 3. Add the emulsion into the feed temporary storage tank, evacuate to 0.09MPa, and stir for 1 hour.

[0040] 4. One-step granulation of the emulsion by spray-starch fluidized bed drying method, the conditions are: air inlet temperature 50°C, starch fluidized bed blast temperature...

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Abstract

The invention relates to a preparation method of a pressure-proof lycopene microcapsule. The preparation method comprises the following specific operation steps: adding a composite wall material, a filling agent, a water-soluble emulsifying agent and a water-soluble antioxidant into purified water, heating and stirring to dissolve the components, then adding an oil-soluble antioxidant, and uniformly dispersing, so as to prepare a water phase; adding lycopene crystals into a water phase under a high-speed shearing condition for emulsification, and homogenizing by virtue of a high-pressure homogenizing machine; adding the homogenized emulsion into a temporary storage tank, vacuumizing, and stirring; and carrying out one-step granulation on the emulsion by virtue of an atomizing-starch fluid bed drying method, so as to obtain the lycopene microcapsule. The mechanical strength of the lycopene microcapsule reaches above 100g, and the content retention rate is higher than 95%, so that the tabletting requirement can be met.

Description

technical field [0001] The invention belongs to carotenoid microcapsule technology, and in particular relates to a preparation method of pressure-resistant lycopene microcapsules and lycopene microcapsules. Background technique [0002] Lycopene is a kind of carotenoid. Lycopene has superior performance than other carotene. For example, the ability to scavenge singlet oxygen is 100 times that of vitamin E and twice that of β-carotene. many. Lycopene can improve the body's immunity, inhibit the proliferation of cancer cells, reduce DNA damage, prevent low-density lipoprotein oxidation, and reduce blood cholesterol levels, so it can reduce the incidence of various diseases. The molecular structure of lycopene is a non-cyclic planar conjugated polyunsaturated aliphatic hydrocarbon containing 11 carbon-carbon double bonds. The multiple unsaturated double bond structure of lycopene determines that it is easily degraded and oxidized by light, oxygen and heat. On the one hand, as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/01A61K9/20A61K9/50A61K47/36A61K47/42A61P39/06A61P37/04A61P35/00A61P3/06
CPCA61K9/2081A61K9/5036A61K9/5057A61K9/5089A61K31/01
Inventor 徐建中贾新超杨文江李新愿杨香瑜
Owner CHENGUANG BIOTECH GRP CO LTD
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