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Method for manufacturing hydrophilic lubricating coating on surface of medical interventional catheter

A technology for intervening catheters and lubricating coatings, applied in catheters, coatings, etc., can solve the problems of easy falling off of coatings and limited connection points, and achieve the effects of firm hydrophilic lubrication, reduced friction, and excellent friction resistance.

Inactive Publication Date: 2016-10-05
BEIJING DEMAX MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, only a single polymer is used to coat the catheter, and the coating is still easy to fall off after absorbing water, and limited by the grafting efficiency of the catheter, the connection points between the polymer and the catheter surface are limited, so other components are required to cooperate, and other Chemical reaction immobilizes hydrophilic polymer

Method used

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  • Method for manufacturing hydrophilic lubricating coating on surface of medical interventional catheter

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of side carboxyl group-containing polyurethane (PU): use solvent method to synthesize side carboxyl group-containing polyurethane, add polyether or polyester diol and diisocyanate into the reactor, raise the temperature to 70°C, stir and react for 1 hour to obtain a prepolymer, Add 2,2-dimethylol propionic acid and 1,4-butanediol, react for 2 hours, add N,N-dimethylformamide, continue the reaction for 1 hour, add dibutyltin dilaurate, and then Reacted for 8 hours, down to room temperature, the solution in the reactor was poured into a container with deionized water, a white precipitate was precipitated, collected the precipitate and washed 3 times with deionized water, placed in a vacuum drying oven, at 90 After vacuum drying at ℃ for 48 hours, a transparent block product was obtained, which was granulated to obtain a side carboxyl group-containing polyurethane masterbatch.

[0037] Wherein, described polyether or polyester diol is selected from polyoxypropy...

Embodiment 2

[0043] Add side carboxyl group-containing polyurethane PU-1, triphenylmethane-4,4',4"-triisocyanate, and N,N-dimethylformamide into the container, and stir at room temperature for 30 minutes to obtain a primer, The mass ratio of PU-1 to triphenylmethane-4,4',4"-triisocyanate is 1:1, and the mass of N,N-dimethylformamide is 95 wt% of the total mass of the primer. Add side carboxyl group-containing polyurethane PU-1, polymethyl vinyl ether-maleic anhydride, and ethyl acetate into the container, and stir at room temperature for 30 minutes to obtain a top coat, in which PU-1 and polymethyl vinyl ether - the mass ratio of maleic anhydride is 1:8, ethyl acetate is 90wt% of the total mass of the top coat, polymethyl vinyl ether-maleic anhydride is a product of Sigma Aldrich Company, and the number average molecular weight is 80000, three Phenylmethane-4,4',4"-triisocyanate is a product of Bayer's Desmodur RE model.

[0044] Place the interventional catheter in the sample chamber of ...

Embodiment 3

[0048]Add the prepolymer of polyurethane PU-2 containing side carboxyl groups, 2,4-toluene diisocyanate, and tetrahydrofuran into the container, and stir at room temperature for 30 minutes to obtain a primer, in which PU-2 and 2,4-toluene diisocyanate The mass ratio of the prepolymer is 1:3, and the mass of tetrahydrofuran is 80wt% of the total mass of the primer. Add side carboxyl group-containing polyurethane PU-2, polymethyl vinyl ether-maleic anhydride, and dichloromethane into the container, and stir at room temperature for 30 minutes to obtain a top coat, in which PU-2 and polymethyl vinyl ether - the mass ratio of maleic anhydride is 1:10, methylene chloride is 99wt% of the total mass of the top coat, polymethyl vinyl ether-maleic anhydride is a product of Sigma Aldrich Company, and the number average molecular weight is 80000, 2 , The prepolymer of 4-toluene diisocyanate is the Desmodur RC type product of Bayer Company.

[0049] Place the interventional catheter in th...

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Abstract

The invention relates to a method for manufacturing a hydrophilic lubricating coating on the surface of a medical interventional catheter. The surface of the catheter undergoes plasmid processing and acrylic acid grafting, so that the surface contains active carboxyl; and then, a dual-layer coating system is constructed, so that a multi-component cross-linked structure is formed, wherein a polyisocyanate curing agent functions as a cross-linking agent for connecting the carboxyl in the surface of the catheter, polyurethane in the coating and a hydrophilic polymer, namely poly (vinyl methyl ether)-maleic anhydride, so that the bottom of the coating is in covalent bond connection with the catheter and the bottom of the coating is firmly combined with the top of the coating; and the coating surface is hydrophilic and lubricant and is firm and wear-resistant as well, and is suitable for hydrophilic lubrication treatment of such instruments as the interventional catheter and the like in the endovascular intervention diagnosis and treatment technology.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a method for preparing a hydrophilic lubricating coating on the surface of a medical intervention catheter. Background technique [0002] Intravascular interventional diagnosis and treatment technology is widely used in clinical angiography, angioplasty, removal of intravascular thrombus or foreign body, etc. Compared with traditional medical technology, it is not only convenient to operate, but also reduces the pain of patients due to the low trauma of interventional treatment , the risk of treatment is small, and the cost of treatment is relatively low, so this technology has been widely promoted and used in the medical field. Intravascular interventional diagnosis and treatment technology is to use interventional catheters to reach distant diseased parts in the body through the vascular lumen, such as coronary arteries and other vascular parts, and then inject diagnostic agents ...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14
Inventor 王兴元戴华英
Owner BEIJING DEMAX MEDICAL TECH
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