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Hydrophilic lubricating polyurethane medical interventional catheter and manufacturing method thereof

An interventional catheter, water-based polyurethane technology, applied in the field of medical devices, can solve problems such as lack of chemical bond connection, unsatisfactory coating firmness, and combination of catheter base material and coating

Active Publication Date: 2016-10-05
BEIJING DEMAX MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the basically disclosed technologies are all focused on improving the coating, such as modifying the cross-linked structure, etc., but none of them effectively combine the catheter base material and the coating together, and there is a lack of Chemical bond connection, in their own independent systems, the firmness of the coating is still not ideal

Method used

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  • Hydrophilic lubricating polyurethane medical interventional catheter and manufacturing method thereof
  • Hydrophilic lubricating polyurethane medical interventional catheter and manufacturing method thereof
  • Hydrophilic lubricating polyurethane medical interventional catheter and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Preparation of carboxyl-containing thermoplastic polyurethane elastomer (CTPU):

[0047] Synthesize carboxyl-containing polyurethane elastomer by solvent method, add polyether or polyester diol and diisocyanate into the reactor, heat up to 80°C, stir and react for 2 hours to obtain prepolymer, add 2,2-dimethylol Propionic acid and 1,4-butanediol, reacted for 30 minutes, added N,N-dimethylformamide, continued to react for 1 hour, added dibutyltin dilaurate, reacted for another 6 hours, and cooled to room temperature, Pour the solution in the reactor into a container with deionized water, and a white precipitate precipitated out. The precipitate was collected and washed 3 times with deionized water, placed in a vacuum drying oven, and dried in vacuum at 110°C for 48 hours to obtain It is a transparent block product, which is pelletized to obtain a carboxyl group-containing polyurethane elastomer masterbatch.

[0048] Wherein, described polyether or polyester diol is sele...

Embodiment 2

[0054] Preparation of carboxyl-free thermoplastic polyurethane elastomer (TPU):

[0055] Polyurethane elastomer without carboxyl groups is synthesized by melting method, polyether or polyester diol and diisocyanate are added into the reactor, the temperature is raised to 80°C, and the prepolymer is obtained after stirring for 2 hours, and 1,4-butanediol is added , after stirring for 5 minutes, pour the liquid in the reactor into the tray, place the tray in a vacuum drying oven, depressurize and pump air at room temperature until there is no foaming in the liquid, and then place it in a vacuum drying oven under normal pressure After curing at 110° C. for 24 hours, the bulk product was taken out from the tray and pelletized to obtain a carboxyl-free polyurethane elastomer masterbatch.

[0056] Wherein, described polyether or polyester diol is selected from polyoxypropylene diol (PPG), polytetrahydrofuran diol (PTMG), polycarbonate diol (PCDL), polycaprolactone diol (PCL) One of...

Embodiment 3

[0062] Preparation of water-based polyurethane emulsion (WPU):

[0063] Add polyether or polyester diol and diisocyanate into the reactor, raise the temperature to 80°C, stir and react for 2 hours to obtain a prepolymer, add 2,2-dimethylol propionic acid and 1,4-butanediol , after 30 minutes of reaction, the temperature dropped to 60°C, added acetone, continued to react for 1 hour, added dibutyltin dilaurate, reacted for another 6 hours, lowered to room temperature, added triethylamine, stirred for 10 minutes, added deionized water, use a high-speed mixer to emulsify the product for 10 minutes at a stirring speed of 8000 rad / min, and distill off the acetone in the product by vacuum distillation to obtain a water-based polyurethane emulsion.

[0064] Wherein, described polyether or polyester diol is selected from polyoxypropylene diol (PPG), polytetrahydrofuran diol (PTMG), polycarbonate diol (PCDL), polycaprolactone diol (PCL) One of the number average molecular weight (M n ...

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Abstract

The invention relates to a hydrophilic lubricating polyurethane medical interventional catheter and a preparation method thereof. The tube body material of the catheter is a melt-mixed material of carboxyl-containing thermoplastic polyurethane elastomer and carboxyl-free thermoplastic polyurethane elastomer. The outer surface of the catheter is coated with A hydrophilic coating that can be covalently bonded to the catheter, the hydrophilic coating includes a bottom coating that can be grafted to the outer surface of the catheter, and a top coating that forms a semi-interpenetrating cross-linked network structure with the bottom coating . The present invention utilizes the chemical bond grafting technology of the catheter and the coating and the semi-interpenetrating network construction technology of the hydrophilic polymer and the coating to effectively combine the catheter and the coating closely, and obtain high lubricity and wear resistance. The polyurethane medical interventional catheter is suitable for use in the field of endovascular interventional diagnosis and treatment.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a hydrophilic lubricating polyurethane medical intervention catheter and a preparation method thereof. Background technique [0002] Intravascular interventional diagnosis and treatment technology is widely used in clinical angiography, angioplasty, removal of intravascular thrombus or foreign body, etc. Compared with traditional medical technology, it is not only convenient to operate, but also reduces the pain of patients due to the low trauma of interventional treatment , the risk of treatment is small, and the cost of treatment is relatively low, so this technology has been widely promoted and used in the medical field. Intravascular interventional diagnosis and treatment technology is to use interventional catheters to reach distant diseased parts in the body through the vascular lumen, such as coronary arteries and other vascular parts, and then inject diagnostic agents or in...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/06A61L29/14C08J7/04C09D175/08C09D175/06C09D7/12
Inventor 王兴元戴华英
Owner BEIJING DEMAX MEDICAL TECH
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