Tebipenem pivoxil granule and preparation method thereof
A technology of tipipenem ester and granules, which is applied in the field of medicine and its preparation, can solve the problems of highly allergenic substances, affecting product quality and curative effect, poor stability of tipipenem ester, etc., so as to facilitate dissolution and absorption, and improve packaging Coating efficiency, the effect of improving coating quality
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Embodiment 1
[0035] The formula of Tippenem Methoxylate Granules is as follows:
[0036] Raw materials
Dosage g
Ratio w / w%
Tippenem
655
11.80
1000
18.02
3000
54.05
45
0.81
talcum powder
49.3
0.89
Ethyl cellulose suspension
433
7.80
Hydroxypropylmethylcellulose
10.3
0.19
18.5
0.33
Ethyl acrylate-methyl methacrylate copolymer water dispersion
339
6.11
[0037] Refer to figure 1 , The preparation method of tippenem meximate granules includes the following steps:
[0038] Step S1: prepare a hydroxypropyl cellulose solution, mix the hydroxypropyl cellulose with pure water, and stir to prepare a solution with a mass percentage of 2 wt%; respectively prepare coating agent I and coating agent II into solutions for use;
[0039] Step S2: Pass the tipipenem ester and diluent through a 100-mesh sieve, weigh the formulated amount of tipipenem ester, microcrystalline cellulose and sucrose, and add them to the fluidized bed granulation...
Embodiment 2
[0047] The formula of Tippenem Methoxylate Granules is as follows:
[0048] Raw materials
Dosage g
Ratio w / w%
Tippenem
655
11.80
1000
18.02
3000
54.05
45
0.81
talcum powder
49.3
0.89
Ethyl cellulose suspension
433
7.80
Hydroxypropylmethylcellulose
10.3
0.19
18.5
0.33
Ethyl acrylate-methyl methacrylate copolymer water dispersion
339
6.11
[0049] The preparation method of Tippenem Methoxylate granules includes the following steps:
[0050] Step S1: Prepare a hydroxypropyl cellulose solution, mix the hydroxypropyl cellulose with pure water, and stir to prepare a solution with a mass percentage of 2 wt%; respectively prepare coating agent I and coating agent II into solutions, see implementation Example 1, spare;
[0051] Step S2: Pass the tipipenem ester and diluent through a 120-mesh sieve, weigh the formula amount of tipipenem ester, microcrystalline cellulose and sucrose, add them to the fluidized bed granul...
Embodiment 3
[0057] The formula of Tippenem Methoxylate Granules is as follows:
[0058] Raw materials
Dosage g
Ratio w / w%
Tippenem
655
11.80
Microcrystalline cellulose
1000
18.02
sucrose
3000
54.05
45
0.81
talcum powder
49.3
0.89
Ethyl cellulose suspension
433
7.80
Hydroxypropylmethylcellulose
10.3
0.19
18.5
0.33
Ethyl acrylate-methyl methacrylate copolymer water dispersion
339
6.11
[0059] The preparation method of Tippenem Methoxylate granules includes the following steps:
[0060] Step S1: Prepare a hydroxypropyl cellulose solution, mix the hydroxypropyl cellulose with pure water, and stir to prepare a solution with a mass percentage of 2 wt%; respectively prepare coating agent I and coating agent II into solutions, see implementation Example 1, spare;
[0061] Step S2: Pass the tipipenem ester and diluent through a 200-mesh sieve, weigh the formula amount of tipipenem ester, microcrystalline cellulose and sucrose, add them to the fluidized bed granul...
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