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Polypyrrole nano particle having photo-thermal effect, preparation method and application thereof

A technology of polypyrrole nanometer and photothermal effect, which is applied in the interdisciplinary field of nanoengineering and cell biology, can solve the problems of non-biodegradable, adverse reactions, long-term persistence, etc., achieve good photostability, inhibit restenosis, and inhibit local chronic inflammation Effect

Inactive Publication Date: 2016-08-10
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

Most of the nanoparticles currently used in photothermal therapy are inorganic substances, including gold nanorods, copper nanomaterials, carbon nanomaterials, and Pdnanosheets. The above inorganic substances have the following defects: they cannot be biodegraded and can persist in the body for a long time. resulting in unexpected clinical adverse reactions, etc.

Method used

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  • Polypyrrole nano particle having photo-thermal effect, preparation method and application thereof
  • Polypyrrole nano particle having photo-thermal effect, preparation method and application thereof
  • Polypyrrole nano particle having photo-thermal effect, preparation method and application thereof

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Experimental program
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Embodiment 1

[0033] Using near-infrared rays to irradiate polypyrrole nanoparticles (PPy nanoparticles), and using immunofluorescence and HE staining to identify its inhibitory effect on vascular chronic inflammation and intimal thickening; including the following steps:

[0034] (1) Synthesis of PPy nanoparticles and functional testing

[0035]First, 0.5g of PVA (≈10kDa) was dissolved in 10mL of deionized water, then 0.63g of ferric chloride was added to the reaction mixture and stirred for 30min, and finally, 69μL of polypyrrole monomer was added dropwise to the reaction mixture; after 24h of polymerization, The extra PVA was removed by an ultrafiltration filter with a molecular weight cut-off of 100kDa to obtain PPy nanoparticles; the size and shape of the PPy nanoparticles were detected by high-resolution transmission electron microscopy; The color dish is used to measure its ultraviolet light absorption spectrum, the optical channel is 1cm, and 915nm near-infrared laser is used for ir...

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Abstract

The invention belongs to the crossing field of nano engineering and cell biology, and relates to a polypyrrole nano particle having a photo-thermal effect, a preparation method and an application thereof. The nano particle generates heat under irradiation of near infrared ray and can be used for preparing a medicine preparation for treating hemadostenosis caused by inflammatory reaction in blood vessel and vascular smooth muscle cell proliferation. In the invention, on the basis of killing effects on chronic inflammatory cells in vitro with photo-thermal therapy of the nano particle and near infrared laser, an application test of mouse vascular chronic inflammation and in an arteriostenosis model is carried out further, and a result proves that the nano particle can locally enter the focus of the chronic inflammation in artery, and can be used for inhibiting the local chronic inflammation with near infrared ray local irradiation, thereby inhibiting restenosis after intracavitary therapy and being used for evaluating the restenosis after intracavitary therapy through MRI.

Description

technical field [0001] The invention belongs to the interdisciplinary field of nanoengineering and cell biology, and relates to a polypyrrole nanoparticle with photothermal effect and its preparation method and application; the nanoparticle has the characteristic of heating under near-infrared irradiation, and can be used for preparing and treating Drug preparations for vascular stenosis caused by vascular inflammation and proliferation of vascular smooth muscle cells. Background technique [0002] As the aging society enters, the heart and cerebrovascular injury caused by atherosclerosis (AS) seriously affects and threatens human health, and heart and cerebrovascular diseases have become the number one cause of human death; therefore, prevention and treatment AS and vascular injury have always been the focus and difficulty of research in this field. It is known that lipid deposits in the arterial subintima and atherosclerotic plaques progress, resulting in high stenosis of...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/14A61P9/14A61P29/00A61P9/10
Inventor 陆信武彭智猷秦金保叶开创袁福康杨心蕊黄丽佳蒋米尔
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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