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Radix linderae extract for treating diabetic bladder dysfunction disease and preparation method thereof

A technology of bladder dysfunction and extract, which is applied in the field of medicine, can solve the problems of bladder dysfunction disease research and lack of therapeutic drugs, and achieve wide application prospects and good curative effects

Inactive Publication Date: 2016-07-27
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are very few drugs that can really effectively achieve the purpose of treatment. Generally speaking, the research and treatment of bladder dysfunction diseases are still relatively lacking.

Method used

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  • Radix linderae extract for treating diabetic bladder dysfunction disease and preparation method thereof
  • Radix linderae extract for treating diabetic bladder dysfunction disease and preparation method thereof
  • Radix linderae extract for treating diabetic bladder dysfunction disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 black medicine extract

[0032] Take black herb, cleanly select, remove impurities, dry and pulverize at low temperature, add 4 times the mass of 50% ethanol to heat and reflux to extract, filter with 200 mesh, and repeat heating and reflux to extract the filter residue twice, combine three alcohol extracts to concentrate under reduced pressure, spray After drying, pulverize and pass through an 80-mesh sieve to obtain the black medicine extract.

Embodiment 2

[0033] The identification of embodiment 2 black medicine extract

[0034] 1. Determination of Higastrolide Lactone by High Performance Liquid Chromatography

[0035] Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel was used as filler; acetonitrile-water (56:44) was used as mobile phase; detection wavelength was 235nm. Preparation of Reference Substance Solution Take 10 mg of higlobalactone reference substance, accurately weigh it, put it in a 100ml measuring bottle, dissolve it with methanol and dilute to the mark, shake well, accurately measure 10ml, put it in a 25ml measuring bottle, add methanol to Scale, shake well, and get it (every 1ml contains 40μg of higranate lactone). Preparation of the test solution: Take about 1 g of the coarse powder of this product, weigh it accurately, place it in a Soxhlet extractor, add 50 ml of ether, extract for 4 hours, evaporate the extract to dryness, dissolve the residue in stages with methanol, a...

Embodiment 3

[0043] Example 3 The effect of herbal extracts on bladder function and capacity in diabetic mice

[0044] 1. Experimental method

[0045] (1) Diabetes modeling method: C57 mice were adaptively fed for 1 week, weighed and randomly divided into two groups according to the digital table method, normal control group and model group. The model group was fed with high fat for 8 weeks, and the normal control group was fed with common feed. All animals had free access to food and water. After fasting for 12 hours in the eighth week, the mice were intraperitoneally injected with STZ 200mg / kg, and the normal control group was intraperitoneally injected with the solvent according to the fasting body weight. The fasting blood glucose ≥ 10.5mmol / L after one-time injection of STZ 3 days was used as the modeling standard.

[0046] (2) Administration method: the model mice were randomly divided into 2 groups, the model control group was administered with distilled water, the dosage of the bl...

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Abstract

The invention discloses a radix linderae extract for treating diabetic bladder dysfunction disease and a preparation method thereof. The radix linderae extract prepared by the preparation method has a perfect curative effect on bladder dysfunction disease and particularly diabetic bladder dysfunction disease and can be used for preparing a related medicine; and the medicine consists of the radix linderae extract and medically acceptable accessories, wherein 500-5,000mg of radix linderae extract is contained in daily dosage. The radix linderae extract and medicine thereof can regulate the diastolic and systolic tension of the bladder smooth muscle so as to regulate the bladder function; and the mechanism is related to a cholinergic nerve receptor (M receptor), a beta-adrenergic receptor (beta-AR) and a non-cholinergic non-adrenergic TRPV1 passage. Therefore, the radix linderae extract can be used for preventing and treating bladder dysfunction disease and has wide application prospects in preparing a medicine for preventing and / or treating diabetic bladder dysfunction disease.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to an extract of black medicine for treating diabetic bladder dysfunction and a preparation method thereof. Background technique [0002] Diabetic bladder dysfunction (diabetic bladderdysfunction, DBD), also known as diabetic neurogenic bladder (diabetic neurogenic bladder), is the manifestation of diabetic peripheral neuropathy in the urinary system. DBD disease often has storage symptoms and voiding symptoms, and in the early stage of the disease, it often manifests as detrusor overactivity (or called unstable bladder). With the prolongation of the onset, detrusor decompensation occurs, and bladder contractility or flaccid bladder appears. In addition to the general control of blood sugar and the treatment of diabetic neuropathy, the treatment of DBD should also treat bladder sensory and motor disturbances, avoid excessive swelling of the detrusor muscle, and pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P13/10A61P3/10
CPCA61K9/0019A61K9/0031A61K9/0034A61K9/0043A61K9/0048A61K9/0053A61K9/0073A61K9/08A61K9/10A61K9/107A61K9/12A61K36/54A61K2236/333A61K2236/39A61K2236/51
Inventor 操红缨黄萍谈博吴清和连大卫范平龙江伟雯
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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