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Application of clostridium butyrate in preparation for prevention and treatment or adjuvant therapy of hyperglycemia

A technology of Clostridium spp. and Bacillus zoster, applied in the field of diabetes prevention and treatment, can solve problems such as affecting the quality of life and physical health, difficult to cure type 2 diabetes, limited clinical application of probiotics, etc., and achieves improvement of hyperglycemia and increased abundance. , the effect of changing the composition

Active Publication Date: 2016-07-20
QINGDAO EASTSEA PHARMA
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Problems solved by technology

[0003] Type 2 diabetes is difficult to cure, and can only control blood sugar and complications through reasonable diet control, physical exercise and drugs, seriously affecting people's quality of life and health, and depleting health resources
However, the clinical application of probiotics in the treatment of metabolic syndrome is still very limited, mainly because of our lack of understanding of their mechanism of action

Method used

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  • Application of clostridium butyrate in preparation for prevention and treatment or adjuvant therapy of hyperglycemia
  • Application of clostridium butyrate in preparation for prevention and treatment or adjuvant therapy of hyperglycemia
  • Application of clostridium butyrate in preparation for prevention and treatment or adjuvant therapy of hyperglycemia

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preparation example Construction

[0034] Preparation of bacterial solution: Dissolve the bacterial powder of each strain in sterile water to 1.575×10 8 CFU / mL bacterial solution (dissolve with use).

[0035] Preparation of sodium butyrate solution: Dissolve 2 g of sodium butyrate in sterile water to form a 2 g / ml solution (dissolve as needed).

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Abstract

The invention discloses an application of clostridium butyrate in a preparation for prevention and treatment or adjuvant therapy of hyperglycemia and belongs to the technical field of prevention and treatment of diabetes. According to the application, during the prevention and treatment or adjuvant therapy of the hyperglycemia, butyric acid is produced in an intestinal tract, meanwhile, florae of the intestinal tract are changed, signals are sent to an ileum, a liver, a pancreatic gland and a brain by a portal vein blood sugar sensor, the ileum is promoted to secrete (GLP-1) glucagon-like peptide-1, the gluconeogenesis of the liver is lowered, pancreatic beta cells are protected, the secretion of insulin of the pancreatic gland is promoted, and thus, the action of reducing blood sugar is exerted. The clostridium butyrate is a medicine which has been proven by clinical drug trials and can be directly taken orally.

Description

technical field [0001] The invention relates to the application of Clostridium butyricum in preparations for prevention and treatment of hyperglycemia and belongs to the technical field of diabetes prevention and treatment. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia caused by multiple etiologies, which is caused by defects in insulin secretion and (or) action. Symptoms are related to metabolic disorders, especially "three excesses and one deficiency". However, according to the current research on the pathogenesis of diabetes, it is generally believed that diabetes may be related to genetic susceptibility, unhealthy diet, and sedentary lifestyle. In recent years, some studies have suggested that the composition of gut microbes is closely related to diabetes-related energy metabolism disorders . Diabetes, especially type 2 diabetes, is distributed worldwide. In recent years, the incidence has increa...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/742A61P3/10A61P1/00A61K35/745A61K35/747A61K35/744A23L33/135
CPCA23V2002/00A61K35/742A61K35/744A61K35/745A61K35/747A61K2300/00A23V2200/328A23V2200/3204
Inventor 孙嘉陈永泉贾玲玲
Owner QINGDAO EASTSEA PHARMA
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