Application of ergosterol and ergosterol liposome prepared from ergosterol
A technology of ergosterol lipids and keratosterol lipids, applied in the field of lung cancer drugs, can solve the problems of undiscovered anti-lung cancer effects, hindering the research of anti-cancer drugs, complex components of Antrodia antrodia, and achieve anti-lung cancer effects, small damage, and cytotoxicity low effect
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[0023] A use of ergosterol for treating lung cancer.
Embodiment 2
[0025] A kind of ergosterol liposome for the treatment of lung cancer, the drug loading capacity of ergosterol (commercially available, U.S. Sigma company) in the described ergosterol liposome is 5-20wt%, and described liposome is composed of lecithin and Cholesterol composition, the molar ratio of lecithin to cholesterol is 1:1-7:1.
[0026] Best preparation technology of ergosterol liposome
[0027] 1. Single factor investigation
[0028] 1.1 Investigation on the molar ratio of lecithin to cholesterol
[0029] This experiment investigated the ratio (molar ratio) of lecithin and cholesterol when ergosterol was loaded with 5% drug. The ratios of the two were set to 1:1, 3:1, 5:1, and 7:1, and the encapsulation efficiencies were respectively 71.59%, 89.15%, 92.58%, 96.62%. When the ratio of the two is 1:1, due to the high ratio of cholesterol, the rigidity of the liposome is enhanced, and when the ratio is 7:1, precipitation is prone to occur after placement.
[0030] 1.2 P...
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