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Sugar ligand preparation capable of inhibiting growth of candida albicans

A preparation, lactose technology, applied in the directions of medical preparations containing active ingredients, antifungal agents, topical antibacterial agents, etc., can solve the problems of limited application, repeated bactericidal treatment effects, etc., and achieve high safety and recurrence prevention. Effect

Inactive Publication Date: 2016-07-13
王冬颖 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] What the present invention aims to solve is the problem that the simple bactericidal treatment effect in the treatment of Candida albicans vaginitis or thrush in the prior art is repeated, and the application in pregnant women and postpartum women is limited. Agents of carbon source utilization in candida conditionally pathogenic environments

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Preparation of Sabao medium (containing 4% glucose) and stock solutions of lactose (20%), inulin (30%) and lactose (20%)+inulin (30%) for control.

[0018] Heat and dissolve the commercially available Sabau medium powder in sterile water. A part is used as the culture medium for control observation, and a part is used to prepare the sabao culture medium in the dissolved state to dissolve and prepare a liquid culture medium with a storage concentration of lactose, inulin and lactose at a specific concentration.

Embodiment 2

[0019] Example 2: Preparation of Candida albicans medium with different concentrations of lactose, inulin and lactose+inulin.

[0020] The storage solution of Example 1 was taken as 100% and diluted by 75%, 50%, and 25% respectively, and the culture medium of different concentrations was prepared by using the sabao culture medium used in the control as the dilution and dissolution.

Embodiment 3

[0022] For preparation of equal volume culture plates, equal volumes of media with different sugar concentrations were prepared on multi-well culture plates. At the same starting time, about 5*10^3 Candida albicans species of the same amount were implanted for each experimental concentration (4 wells repeated for each concentration), and the Candida albicans conventional culture medium was used as a control observation group. Observe for 72 hours, and take a hole every 24 hours for quantitative comparison of bacterial spores. Observe the quantitative growth results of Candida albicans in the following table. The growth curve of the sabao culture medium in the control group was significantly higher than that of the other sugar intervention groups, and the consumption of the necessary substances for the culture in the control group also decreased after more than 72 hours of culture, and all kinds of cultures showed a similar degree of inhibition. In all sugar concentrations, th...

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PUM

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Abstract

The invention discloses a sugar ligand preparation capable of inhibiting the growth of candida albicans. A formula comprises main sugar components including lactose and inulin; other components can have needed or improved properties of the preparation, and added essence and menthol, and excipients for preparing other preparations are sensed; the effective concentration region of the lactose is 10 percent to 20 percent; the effective concentration region of the inulin is 15 percent to 30 percent. The formula reaches the bacterium inhibition effect through changing a carbon source composition ratio of a growth environment, aiming at that the candida albicans is conditional pathogenic bacteria and microbiological characteristics that the lactose and the inulin cannot be used as growth carbon sources. Furthermore, the lactose is a substrate for the growth of profitable strains in a vagina, and the substrate lactose in a microenvironment of the vagina is increased, so that the growth of normal lactobacillus in the vagina can be easily recovered and physiological balance is recovered. The effective components of the formula preparation comprise the lactose and the inulin, the safety is higher and the cost of the raw materials is low, so that the sugar ligand preparation can be applied during a pregnancy duration and a lactation period and is also suitable for appropriate crowd in other age ranges.

Description

technical field [0001] The present invention relates to a sugar formulation for inhibiting the growth of Candida albicans Background technique [0002] Candida albicans is an opportunistic pathogenic fungus in the human body. It mainly occurs in the vagina, oral cavity and other parts. It occurs frequently in people with high blood sugar, decreased immunity, and long-term use of antibiotics. Candida albicans is a normal flora in the female vagina, and in most cases it is in a non-pathogenic state. It is pathogenic and causes diseases such as vaginitis and thrush. Long-term use of antibiotics and immunosuppressants, and imbalance of normal vaginal flora. [0003] What mainly use in the external preparation of existing gynecological treatment Candida albicans at present is the suppository containing antifungal drug. There are few preparations aimed at changing the microecological environment in the vagina, and there is even a lack of preparations aimed at affecting the utili...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7016A61K31/733A61K31/045A61P31/10A61P31/02
CPCA61K31/7016A61K31/045A61K31/733A61K2300/00
Inventor 不公告发明人
Owner 王冬颖
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