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Integrated total internal reflecting microfluidic chip detection all-in-one machine

A microfluidic chip and total internal reflection technology, applied in measuring devices, instruments, fluorescence/phosphorescence, etc., can solve the problems of lack of integrated detection equipment, etc., and achieve strong adaptability, uniform and constant temperature, and uniform and constant humidity Effect

Active Publication Date: 2016-06-29
CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Abstract
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Problems solved by technology

However, the all-in-one machine that integrates the two technologies is still relatively rare, and there is a lack of integrated testing equipment for both technologies

Method used

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  • Integrated total internal reflecting microfluidic chip detection all-in-one machine
  • Integrated total internal reflecting microfluidic chip detection all-in-one machine

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Embodiment Construction

[0016] see Figure 1-2 , an integrated total internal reflection microfluidic chip detection all-in-one machine, which is composed of a main box 1, a control box 19 and a processing display 15, and is characterized in that: the main box 1 has an opening vertically facing forward, and the opening is equipped with Door. The back side wall has a sandwich cavity 22 . The inside of the box body is divided into upper and lower layers by a partition 4, and an inverted microscope 2 is installed in the lower layer box. Installing an inverted microscope is to meet the multi-purpose purpose of one machine, which can be used for both total internal reflection detection and inverted microscope detection. The top of the lens of the inverted microscope 2 faces the observation window 3 , and a sample stage 5 is installed on the top of the partition 4 above the observation window 3 . Two optical fiber excitation light sources 7 are correspondingly installed on the left and right sides of th...

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Abstract

The invention discloses an integrated total internal reflecting microfluidic chip detection all-in-one machine. The all-in-one machine is composed of a mainframe box, a control box and a processing display, wherein the processing display is connected with an inverted microscope and a total internal reflecting optical receiver circuit in the mainframe box, and is further connected with a sample injector and a hot-cold compressor circuit in the control box. A light-guide fiber excitation source light source and an incident light angle calibration scale are installed in the mainframe box. Compared with the prior art, the all-in-one machine disclosed by the invention is capable of fast adjusting the total internal reflecting incident angle, the adaptability for chip detection is strong, the microfluidic chips in different types and different designs can be used. The machine is high in function integration degree, capable of realizing the temperature uniform and constant and humidity uniform and constant in the detection region, and meeting the detection and experiments under different temperature conditions.

Description

technical field [0001] The invention relates to an in vitro diagnostic all-in-one machine, more specifically an integrated total internal reflection microfluidic chip detection all-in-one machine belonging to the field of in vitro diagnosis of medical equipment. Background technique [0002] Total internal reflection fluorescence microscopy is an emerging optical imaging technology in recent years. It uses the evanescent field generated by total internal reflection to illuminate the sample, thereby causing the fluorophores in the optical thin layer with a thickness of hundreds of nanometers to be excited. Fluorescence imaging has a high signal-to-noise ratio. The imaging device of this method is simple, and it is very easy to combine with other imaging techniques and detection techniques. At present, the spatial resolution of 100nm or even lower has been successfully realized. At present, the microfluidic chip has been developed rapidly, but the bottleneck hindering the de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64G01N21/01
CPCG01N21/01G01N21/6402
Inventor 廖晓玲徐紫宸李波肖文谦
Owner CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
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