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Azlocillin sodium drug composition and anti-aging function thereof

A technology of azlocillin sodium and its composition, which is applied in the field of azlocillin sodium pharmaceutical composition, can solve problems such as the related reports of azlocillin sodium and its pharmaceutical composition, and achieve outstanding substantive characteristics, anti Improvement of aging effect, effect of remarkable progress

Inactive Publication Date: 2016-06-08
李晨露
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between azlocillin sodium and its pharmaceutical composition and anti-aging

Method used

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  • Azlocillin sodium drug composition and anti-aging function thereof
  • Azlocillin sodium drug composition and anti-aging function thereof
  • Azlocillin sodium drug composition and anti-aging function thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0016] Separation method: (a) Grind the dry root (2kg) of Anemarrhena, extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until there is no alcohol smell (3L), and then use petroleum ether (3L ×3 times), ethyl acetate (3L×3 times) and water-saturated n-butanol (3L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) In the step (a), the n-butanol extract is removed with a D101 type macroporous resin, and first eluted with 10% ethanol for 8 column volumes, then with 70% ethanol for 10 column volumes, collected 70% eluate, and reduced Concentrate under pressure to get 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 60:1 (10 column volumes), 30:1 successively (8 column volumes), 15:1 (10 col...

Embodiment 2

[0020]Example 2: Effects on learning and memory of D-galactose-induced aging model mice

[0021] 1. Materials and methods

[0022] 1.1 Animals, drugs and reagents

[0023] Healthy Kunming mice, half male and half male, weighing 18-22 g, were provided by the Animal Experiment Center of Guiyang Medical College, clean grade.

[0024] Azlocillin sodium was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. D-Galactose (Amresco, USA); Coomassie Brilliant Blue Protein Assay Kit; Superoxide Dismutase (SOD) Detection Kit; Malondialdehyde (MDA) Detection Kit (Nanjing Jiancheng Bioengineering Institute); Racetam tablets (trade name: Naofukang, Hubei Huazhong Pharmaceutical Co., Ltd.).

[0025] 1.2 Instruments

[0026] 721 UV-Vis spectrophotometer (Shanghai Third Analytical Instrument Factory); Morris water maze (Taimeng Technology Co., Ltd.).

[0027] 1.3 Gr...

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Abstract

The invention discloses an azlocillin sodium drug composition and an anti-aging function thereof. The azlocillin sodium drug composition comprises azlocillin sodium and a natural product compound (I), wherein the natural product compound (I) is of a novel structure and is separated from dried roots of rhizoma anemarrhenae. The azlocillin sodium drug composition has the advantages that when the azlocillin sodium and the compound (I) singly act on a D-galactose model mouse, the learning and memory capabilities of the mouse can be respectively improved; when the azlocillin sodium and the compound (I) jointly act, the improvement function is stronger; meanwhile, when the azlocillin sodium and the compound (I) singly act on the D-galactose model mouse, the SOD (superoxide dismutase) activity of the body is improved, and the function of delaying aging is realized; when the azlocillin sodium and the compound (I) jointly act, the function is more obvious, and the azlocillin sodium drug composition can be developed into an anti-aging drug.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of azlocillin sodium, in particular to a pharmaceutical composition of azlocillin sodium and its anti-aging effect. Background technique [0002] The chemical name of azlocillin sodium is (2S,5R,6R)-3,3-dimethyl-6-[[[[(2-oxo-1-imidazolidinyl)carbonyl]amino]phenylacetyl] Amino]-7-oxo-4-thia-1-azabicyclo[3,2,0]heptane-2-carboxylic acid sodium salt, is a penicillin antibiotic, the third generation broad-spectrum semi-synthetic penicillin, on Gram+ bacteria, Gram-bacteria and anaerobic bacteria are effective and can strongly fight against Pseudomonas aeruginosa. It is suitable for infections caused by G+ bacteria, G- bacteria and anaerobic bacteria, and is effective for Pseudomonas aeruginosa infection. [0003] So far, there is no report on the correlation between azlocillin sodium and its pharmaceutical composition and anti-aging. Contents of the invention [0004] Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/743C07C45/78C07C45/79A61K31/122A61K31/431A61P39/06
CPCC07C49/743A61K31/122A61K31/431C07C45/78C07C45/79
Inventor 李晨露
Owner 李晨露
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