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Preparation method of composite porous microspheres of core-shell structure

A technology of porous microsphere and core-shell structure, which is applied in the direction of medical preparations, microcapsules, and pharmaceutical formulations of non-active ingredients. Problems such as lumps, to achieve the effects of drug loading, good dispersion, and improved slow release

Inactive Publication Date: 2016-05-04
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technology must add initiating groups on the particle surface or in the solution, the polymerization time is longer, and there are many factors affecting the polymerization process
Soak the particles directly in the coating polymer solution. Under the action of intermolecular forces (such as van der Waals force, hydrogen bond, hydrophobic interaction, electrostatic force), a layer of coating polymer can be formed on the surface of the particles, but it will After washing, only a shell layer with a thickness of several nanometers can be obtained, which is not suitable for the sealing of micron-scale surface pores at all (Shchukin et al., Layer-by-layercoatedemulsionmicroparticlesasstorageanddeliverytool, CurrentOpinioninColloid&InterfaceScience, 2012,17,281-289); A mixture of agglomerated coated particles and a large number of free coated polymers is obtained

Method used

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  • Preparation method of composite porous microspheres of core-shell structure
  • Preparation method of composite porous microspheres of core-shell structure
  • Preparation method of composite porous microspheres of core-shell structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. 50mL petroleum ether + 2.4g Span80 + 10mL 0.5wt% sodium alginate solution, emulsified for 1 hour to obtain a water-in-oil emulsion;

[0033] 2. Add 20 mg of chitosan microspheres to the water-in-oil emulsion, stir for 1 hour, let it interact with the sodium alginate in the milk droplet to generate electrostatic attraction, and adsorb on the surface of chitosan porous microspheres;

[0034] 3. After ultrasonically dispersing the emulsion obtained in step 2 for 5min, add 50mL of ethanol, and suction filter to obtain porous chitosan microspheres coated with sodium alginate;

[0035] 4. Put the obtained microspheres into 20mL 2wt% calcium chloride solution and cross-link for 1h to obtain the calcium alginate shell;

[0036] 5. Wash the microspheres obtained in step 4, wash them with distilled water several times, and dry them in vacuum to obtain calcium alginate gel layer-coated porous chitosan composite porous microspheres.

[0037] The scanning electron micrographs of...

Embodiment 2

[0041] 1. 50mL of petroleum ether + 3.2g of Span80 + 8mL of 1wt% polyvinyl alcohol solution, emulsified for 2 hours to obtain a water-in-oil emulsion;

[0042] 2. Add 20 mg chitosan microspheres to the water-in-oil emulsion, stir for 1 hour, let it interact with the polyvinyl alcohol in the emulsion droplet to undergo hydrogen bond interaction, and adsorb on the surface of the chitosan porous microspheres;

[0043] 3. After ultrasonic dispersion of the emulsion obtained in step 2 for 5min, add 50mL of ethanol, and obtain the porous chitosan microspheres coated with polyvinyl alcohol by suction filtration;

[0044] 4. The microspheres obtained in step 4 are washed with ethanol, and vacuum-dried to obtain porous chitosan composite porous microspheres coated with polyvinyl alcohol shells.

Embodiment 3

[0046] 1. 50mL paraffin oil+2gSpan80+10mL1wt% cellulose solution, emulsified for 1.5h to obtain a water-in-oil emulsion;

[0047] 2. Add 20 mg chitosan microspheres to the water-in-oil emulsion, stir for 1 hour, let it interact with the cellulose in the emulsion droplets, and adsorb on the surface of chitosan porous microspheres;

[0048] 3. After ultrasonically dispersing the emulsion obtained in step 2 for 5min, add 50mL of acetone, and obtain the porous chitosan microspheres coated with cellulose by suction filtration;

[0049] 4. Wash the microspheres obtained in step 4, wash them with acetone several times, and dry them in vacuum to obtain porous chitosan composite porous microspheres coated with cellulose shells.

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Abstract

The invention provides a preparation method of composite porous microspheres of a core-shell structure. The method comprises the following steps that a shell material solution, oil-phase dispersion liquid of porous microspheres and an oil-phase solution containing an emulsifying agent are prepared separately; the shell material solution is added into the oil-phase solution containing the emulsifying agent and mixed, and a water-in-oil emulsion is obtained; the oil-phase dispersion liquid of the porous microspheres is added into the water-in-oil emulsion, stirring is conducted, and the porous microspheres coated with shell materials are collected. Compared with the prior art, the preparation method of the composite porous microspheres of the core-shell structure has the advantages that the composite porous microspheres are good in dispersity and free of gathering agglomeration; the preparation technology is simple; the microspheres each has the structure with a dense shell layer and a porous kernel, and improvement of drug-loading capacity and slow release of a drug are facilitated.

Description

technical field [0001] The invention relates to the field of polymer porous microsphere materials, in particular to a method for sealing the surface pores of the polymer porous microsphere, so as to improve the drug slow-release ability of the porous microsphere. Background technique [0002] Biopolymer porous microspheres contain rich pore structures, and they have been widely studied as drug carriers and tissue engineering scaffold materials. In order to overcome the shortcoming of sudden release of drug-loaded microspheres during medication, to enable slow release, reduce side effects, improve drug efficacy and therapeutic effect, the closure of surface pores of drug-loaded porous microspheres is one of the effective methods. How to only close the surface pores without damaging the internal pores is the premise to ensure the drug loading rate and sustained release rate, so the establishment of such methods and technologies is of great significance. For example, South Kor...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K9/52A61K47/36A61K47/38A61K47/34A61K47/42
CPCA61K9/0002A61K9/5026A61K9/5036A61K9/5042A61K9/5057A61K9/5089A61K47/34A61K47/36A61K47/38A61K47/42
Inventor 刘海清吴晓威李济祥
Owner FUJIAN NORMAL UNIV
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