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Degradable silica-based hybrid polymer biomedical elastomer and preparation method thereof

A biomedical and elastic body technology, which is applied in the field of degradable silicon-based hybrid polymer biomedical elastomer and its preparation, can solve problems such as hindering practical application, unfavorable tissue repair, and lack of biological activity, and achieve monomer biophase Good capacitive properties, enhanced mechanical properties and elastic behavior, high biological stability effects

Inactive Publication Date: 2016-04-20
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in recent years, PCD-based elastomers have the following disadvantages: first, low mechanical strength, especially compared with bone tissue; second, PCD is an aliphatic polyester elastomer, and its excessively fast degradation rate Especially in the in vivo environment, it hinders the practical application; third, the pure organic elastomer is not conducive to tissue repair due to the lack of biological activity

Method used

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  • Degradable silica-based hybrid polymer biomedical elastomer and preparation method thereof
  • Degradable silica-based hybrid polymer biomedical elastomer and preparation method thereof
  • Degradable silica-based hybrid polymer biomedical elastomer and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] 1) Preparation of PCD prepolymer: The molar ratio of citric acid: 1,8-octanediol is 1:1.1, and the total mass is 5.0 g. Add it to a 50 mL round-bottomed flask, stir it in a nitrogen environment and put it at 160 °C Melt in an oil bath; after the reaction monomers citric acid and 1,8-octanediol are all melted, the temperature is immediately lowered to 140° C., and the reaction is carried out in a nitrogen environment for 1 hour. The reaction product was washed three times with deionized water, centrifuged, and freeze-dried for later use;

[0038] 2) Preparation of PCD-g-POSS prepolymer: the molar ratio of citric acid: 1,8-octanediol: aminopropyl isobutyl POSS is 1: 1.1: 0.8, and the total mass is 5.0 g. In a 50mL round-bottomed flask, stir and dissolve in a 160°C oil bath under nitrogen atmosphere; after citric acid and 1,8-octanediol are all melted, the temperature immediately drops to 140°C, and the reaction is performed in a nitrogen atmosphere for 1 hour. The reacti...

Embodiment 2

[0042] 1) Preparation of PCD prepolymer: the molar ratio of citric acid: glycerin is 1:0.8, and the total mass is 5.0 g, added to a 50 mL round-bottomed flask, stirred in a nitrogen environment and put into a 160 ° C oil bath to melt; After the reaction monomers citric acid and glycerol were all melted, the temperature was immediately lowered to 142° C., and the reaction was carried out in an argon atmosphere for 1 hour. The reaction product was washed three times with deionized water, centrifuged, and freeze-dried for later use;

[0043] 2) Preparation of PCD-g-POSS prepolymer: according to the molar ratio of citric acid: glycerol: aminopropyl isobutyl POSS of 1:0.8:0.4, the total mass is 5.0g, and added to a 50mL round bottom flask, Stir in a nitrogen environment and put it into a 160°C oil bath to melt; after the citric acid and glycerin are all melted, the temperature immediately drops to 142°C, and the reaction is performed in a nitrogen environment for 1 hour. The react...

Embodiment 3

[0047] 1) Preparation of PCD prepolymer: the molar ratio of citric acid: xylitol is 1:0.9, and the total mass is 5.0 g. Add it into a 50 mL round-bottomed flask, stir it in a 160°C oil bath under nitrogen atmosphere and melt it in an oil bath. ; After the reaction monomers citric acid and xylitol are all melted, the temperature is immediately reduced to 145 ° C, and the reaction is carried out in a helium atmosphere for 1 hour. The reaction product was washed three times with deionized water, centrifuged, and freeze-dried for later use;

[0048] 2) Preparation of PCD-g-POSS prepolymer: the molar ratio of citric acid: xylitol: aminopropyl isobutyl POSS is 1:0.9:0.5, the total mass is 5.0g, and it is added to a 50mL round bottom flask , stir in a nitrogen atmosphere and put it into a 160°C oil bath to melt; after all the citric acid and xylitol are melted, the temperature immediately drops to 145°C, and the reaction is performed in a nitrogen atmosphere for 1 hour. The reaction...

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Abstract

The invention provides degradable silica-based hybrid polymer biomedical elastomer and a preparation method thereof. The degradable silica-based hybrid polymer biomedical elastomer (PCD-POSS) is obtained by preparing PCD prepolymer from citric acid, diol or polyhydric alcohol through thermal polymerization, preparing PCD-g-POSS prepolymer from acid, diol or polyhydric alcohol and POSS through thermal polymerization, dissolving the two types of prepolymer in organic solvent, and adding a cross-linking agent HDI and a catalyst for the cross-linking reaction. The thermal polymerization method used for the method is environmentally friendly, convenient to operate and low in raw material cost. The prepared PCD-POSS has biomimetic viscoelasticity, high chemical strength, good mechanical performance, high biological activity and biological stability, adherency and proliferation of osteoblast and soft tissue cells can be remarkably promoted, and the silica-based hybrid polymer biomedical elastomer has good application prospects in the fields of bone tissue and soft tissue regeneration and medicine transportation.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, in particular to a degradable silicon-based hybrid polymer biomedical elastomer and a preparation method thereof. Background technique [0002] Human tissues, such as bone tissue, muscle, skin and heart, not only have certain mechanical strength and self-healing function, but also have elastic behavior, which is an important guarantee for exerting their physiological functions (FongE.L, WatsonB.M, KasperF. K, MikosA.G.AdvMater.2012;24:4995-5013;PuppiD,ChielliniF,PirasA.Prog.Polym.Sci.2010;35:403-440.), therefore, biomedical materials should be able to simulate the mechanical behavior of tissues and biological activity, thereby ensuring the actual needs in clinical applications. [0003] In recent years, based on organic polymers, there are elastomers that simulate tissue elastic behavior, such as poly-1,3-trimethylene carbonate (PTMC), polyglycerol-sebacic acid (PGS), pol...

Claims

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Application Information

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IPC IPC(8): C08G63/695C08G63/06C08G63/78C08J3/24
CPCC08G63/06C08G63/6952C08G63/78C08J3/246C08J2367/04
Inventor 雷波杜玉章于萌
Owner XI AN JIAOTONG UNIV
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