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Compound propofol water-based injection for dogs, preparing method thereof and application

A propofol water-based, injection technology, which can be used in medical preparations containing active ingredients, pharmaceutical formulations, non-central analgesics, etc., can solve problems such as adverse reactions, avoid drug waste, stabilize the recovery process, and improve The effect of convenience

Inactive Publication Date: 2016-04-20
WENZHOU VOCATIONAL COLLEGE OF SCI & TECH
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Problems solved by technology

However, in large doses, it can also make animals enter a state of deep anesthesia, and adverse reactions often occur at this time

Method used

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  • Compound propofol water-based injection for dogs, preparing method thereof and application
  • Compound propofol water-based injection for dogs, preparing method thereof and application
  • Compound propofol water-based injection for dogs, preparing method thereof and application

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Embodiment Construction

[0025] The present invention is now described by means of examples, and the experimental examples are only for illustration, and are not intended to limit the scope of the present invention.

[0026] Experimental dogs, 6 (female, 4 male, 2), 2.76±0.39kg, 4 months old. The experimental dogs were fasted for 4 hours and water for 2 hours. The optimal prescription (that is, every 100mL injection contains 0.36g of buffer, 30g of cosolvent, 0.005g of chelating agent, 1.0g of propofol, 0.16g of xylazine hydrochloride, and the balance is water for injection. It is a composition of citric acid and sodium citrate in a ratio of 1:5; the cosolvent is 2-hydroxypropyl-β-cyclodextrin; the chelating agent is disodium edetate) administered by intravenous injection (dose 0.3mL / kg), applied to dogs, and observed the induction time, maintenance time, and recovery time after anesthesia. The results are shown in Table 1.

[0027] Changes of various physiological parameters (Table 2, figure 1 ), ...

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Abstract

The invention relates to a compound propofol water-based injection for dogs, a preparing method thereof and application, and belongs to the technical field of veterinary medicine preparation. The compound propofol water-based injection is suitable for immobilizing and narcotizing dogs. The injection uses propofol and xylazine hydrochloride as active components, and a carrier acceptable pharmaceutically is added. The compound propofol water-based injection has hypnosis, calming and abirritation functions and can achieve the effect of anesthesia induction or anesthesia maintenance through one-time injection delivery, and the anesthesia process is more convenient; dosage of all single drugs is reduced, and a good anesthesia effect is achieved with the minimum side effect. The injection is stable in quality and suitable for subcutaneous, muscle and intravenous injection, and pain is avoided in the injection process. A fat emulsion carrier applied the most extensively is abandoned from the preparation, a water-based solution is prepared, microorganism growth can be limited, the injection can be sucked for multiple times, and the problem of medicine waste of a propofol fat emulsion preparation is avoided.

Description

technical field [0001] The invention discloses a compound propofol aqueous injection for dogs and belongs to the technical field of veterinary drug preparation. It is suitable for immobilization and anesthesia of dogs. Background technique [0002] Propofol (2,6-diisopropylphenol) is an alkylphenol intravenous general anesthetic, which is currently widely used in veterinary clinics for induction of anesthesia, maintenance of anesthesia, and sedation. After routine administration, the effect is rapid and the course is stable, and the animals have no side effects such as involuntary muscle movement, coughing, and hiccups. The duration is very short, the awakening is complete, and there is no excitement. It is an ideal hypnotic intravenous general anesthetic, but it has no analgesic effect, so propofol alone cannot achieve the purpose of maintaining anesthesia. [0003] "Diprivan", launched in 1986, is currently the most mature and widely used fat emulsion formulation of prop...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/5517A61P23/00A61P25/08A61P25/20A61P21/02A61P29/00A61K31/05
CPCA61K9/08A61K9/0019A61K31/05A61K31/5517A61K2300/00
Inventor 李培德侯凤香金俊杰周闯胡霖刘素贞白宇金大春王清艳罗厚强简永利李秀红钱锦铭
Owner WENZHOU VOCATIONAL COLLEGE OF SCI & TECH
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