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A kind of compound fluocinolone acetate spray and preparation method thereof

A fluocinolone acetate and spray technology, which is applied in aerosol delivery, pharmaceutical formulations, active ingredients of salicylic acid, etc., can solve the problems of no spray formulation, etc., and achieve improved efficiency, fast drug onset, and stability Good results

Active Publication Date: 2019-06-18
INNER MONGOLIA DATANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinically, the topical drugs for the treatment of neurodermatitis are mainly tinctures and ointments, but there is no corresponding spray formulation

Method used

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  • A kind of compound fluocinolone acetate spray and preparation method thereof
  • A kind of compound fluocinolone acetate spray and preparation method thereof

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preparation example Construction

[0080]The present invention also provides a kind of preparation method of compound fluocinolone acetate spray, comprising the following steps:

[0081] Step a. Accurately weigh the main ingredients and additives, and the solid medicines therein should be subjected to ultrasonic and microwave pulverization, so that the particle size is between 50 and 90 μm, so as to improve the solubility of the solid medicines;

[0082] Step b. After mixing the penetration enhancer and the surfactant, stir evenly in an ultrasonic environment to obtain a stable solution A; mix salicylic acid and glycerin and stir at a constant speed until completely dissolved, then add borneol, resorcinol, and sodium chloride to continue stirring Solution B is obtained until it is completely dissolved; solution C is obtained by mixing fluocinolone acetate and dimethyl sulfoxide at a constant speed until it is completely dissolved. Solutions A, B, and C are all completed in a uniform shaking environment during th...

Embodiment 1－6

[0088] Preparation of compound fluocinolone acetate spray

[0089] The preparation method of the compound fluocinolone acetate spray of the present embodiment may further comprise the steps:

[0090] (1) Weighing and pulverization: Weigh each raw material according to the ratio of raw materials in each embodiment in Table 1, and carry out ultrasonic microwave pulverization on the solid drug therein, so that the particle size is 50-90 μm, so as to improve the solubility of the drug.

[0091] (2) Drug dissolution: Mix peppermint oil and Tween-80 and stir evenly under an ultrasonic environment to obtain a stable solution A. Mix and stir salicylic acid, glycerin and hydrochloric acid for 2 hours until completely dissolved, then add borneol and resorcinol , Sodium chloride was continuously stirred for 1 hour until completely dissolved to obtain solution B; fluocinolone acetate and dimethyl sulfoxide were mixed and stirred for 1 hour until completely dissolved to obtain solution C, ...

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Abstract

The application relates to the field of a medicinal preparation, and more specifically relates to a compound fluocinolone acetonide spraying agent and a preparation method thereof. The compound fluocinolone acetonide novel spraying agent comprises a solvent as well as basic remedy components and additives dissolved in the solvent; the basic remedy components comprise fluocinolone acetonide, salicylic acid, resorcinol, borneol, glycerin and dimethyl sulfoxide; additives comprise a osmotic pressure conditioning agent, a transdermal enhancer, a pH regulator and a surfactant. The compound fluocinolone acetonide novel spraying agent has the advantages of good stability in storage process, rapid effectiveness of medicament, and improved effective rate of disease treatment.

Description

technical field [0001] The application relates to the field of pharmaceutical preparations, in particular to compound fluocinolone acetate spray and a preparation method thereof. Background technique [0002] Neurodermatitis is a chronic skin nerve dysfunction skin disease, which is very common in clinical practice, and mostly occurs in middle-aged and elderly people. parts. At present, it is considered that mental factors are the main cause of this disease, and mood swings, excessive mental stress, anxiety, sudden changes in living environment, etc. can all make the condition worse and repeated. [0003] Clinically, tinctures and ointments are the main topical drugs for the treatment of neurodermatitis. As traditional medicinal dosage forms, tinctures and ointments have many deficiencies and defects. During the course of medication, patients often cannot accurately control and master the dosage. , prone to drug waste and uneven application, the weakened or even ineffectiv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K31/60A61P17/00A61P25/00A61K31/58A61K31/05A61K31/047A61K31/10A61K31/045
CPCA61K9/0014A61K9/12A61K31/045A61K31/047A61K31/05A61K31/10A61K31/58A61K31/60A61K47/26A61K2300/00
Inventor 赵粉荣
Owner INNER MONGOLIA DATANG PHARMA
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