Chip analysis system for chip electrophoretic separation and plasma mass spectrometric detection

Abstract

The invention discloses a chip analysis system fro chip electrophoretic separation and plasma mass spectrometric detection. With a center through hole being the circle center, at least two identical radial flow-distributing channels are formed on the edge of each micro-fluidic chip in a radiated mode and communicated with the center through hole; a separation channel comprises two micro-fluidic chips arranged symmetrically, the micro-fluidic chips are arranged at the initial end and the terminal end respectively, opposite radial flow-distributing channels are communicated through connecting capillary tubes, and porous plugs are evenly arranged inside the radial flow-distributing channels of the micro-fluidic chip at the initial end; the center through hole of the micro-fluidic chip at the initial end is connected with a high-voltage electrode, the center through hole of the micro-fluidic chip at the terminal end is connected with a grounding electrode, and the high-voltage electrode and the grounding electrode are connected with the two ends of a high-voltage power supply respectively; a transfer capillary tube of a outflow channel is connected with a plasma mass spectrometer through an atomizer. The chip analysis system has the advantages of being high in separation efficiency and detection sensitivity, simple in structure, convenient to operate and low in cost.

Description

(1) Technical field [0001] The invention relates to a chip analysis system for chip electrophoresis separation and plasma mass spectrometry detection. (2) Background technology [0002] Information on the speciation of elements in environmental and biological samples helps to understand its toxicity, mobility and bioavailability. Atomic spectrometry, especially plasma mass spectrometry, is a powerful tool for total trace element analysis, but it is difficult to analyze the existing form and content of trace elements in complex matrices such as environment, biology and food. Chromatography has a variety of analysis modes and a wide range of applications. It is an efficient means of analyzing different species of trace elements in complex matrices, especially capillary electrophoresis technology, which has the advantages of high separation efficiency, fast speed and low sample consumption. Capillary electrophoresis coupled with plasma mass spectrometry combines the advantages...

AI Technical Summary

Problems solved by technology

Existing interfaces for capillary electrophoresis and plasma mass spectrometry generally use two-way, three-way or four-way connections to connect high-voltage electrodes, separation capillaries, sheath fluid pipelines and nebulizers, and their dead volumes range from tens of nanoliters. , as many as several microliters, which can easily lead to broadening of electrophoretic peaks

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