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Injectable antibacterial bone cement

An antibacterial bone and injection technology, applied in medical science, prosthesis, etc., can solve problems such as hindering bacterial DNA replication, bacterial DNA structural denaturation, and bacterial death, and achieve good biocompatibility, degradability, and injectability Good, obvious antibacterial effect

Active Publication Date: 2016-03-16
山东明德生物医学工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that silver ions can penetrate the cell wall of bacteria, and can cause bacterial DNA structure denaturation, hinder bacterial DNA replication, and cause bacterial death
However, there is no report on the direct use of sodium hypophosphite to reduce silver salts in the self-curing process of bone cement to enhance the antibacterial properties of bone cement.

Method used

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  • Injectable antibacterial bone cement
  • Injectable antibacterial bone cement
  • Injectable antibacterial bone cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Calcium sulfate 90%, hydroxyapatite 8%, sodium hypophosphite 2%; 2ml concentration is 500mmol / L silver nitrate aqueous solution.

[0048] Take by weighing 4.5g calcium sulfate (calcium sulfate dihydrate 1%), 0.4g hydroxyapatite and 0.1g sodium hypophosphite at room temperature, mix homogeneously; It is the silver nitrate aqueous solution of 500mmol / L that powder is added to 2ml concentration, Mix and stir for 1 minute, and the injectable time is about 5.5 minutes.

[0049] Place the cured bone cement in the SBF solution for 7 days, dry the cured sample and observe it with a scanning electron microscope, as shown in the attached figure 1 As shown, the cured bone cement is mainly lamellar calcium sulfate dihydrate, and hydroxyapatite particles are evenly distributed on the surface of the lamellar object.

[0050] The bone cement was cured in an environment of 37°C and 100% relative humidity, and the compressive strength test was performed on the bone cement sample cured ...

Embodiment 2

[0052]Calcium sulfate 70%, hydroxyapatite 29%, sodium hypophosphite 1%; 3.34ml of silver nitrate aqueous solution with a concentration of 10mmol / L.

[0053] Take by weighing 3.5g calcium sulfate (calcium sulfate dihydrate 10%), 1.45g hydroxyapatite and 0.05g sodium hypophosphite at room temperature, mix uniformly; Add the powder body to 3.34ml concentration and be the silver nitrate aqueous solution of 10mmol / L , mix and stir for 2 minutes, and the injectable time is about 6 minutes.

[0054] The bone cement was cured in an environment of 37°C and 100% relative humidity, and the compressive strength test was performed on the bone cement sample cured for 7 days. The compressive strength test sample was cylindrical (Φ6mm×12mm), and the compressive strength The average value is 9.58Mpa (as attached figure 2 -B shown).

[0055] The bone cement is made into discs (Φ6mm×3mm), and antibacterial experiments are carried out on it. It can be seen that the antibacterial bone cement ha...

Embodiment 3

[0057] Calcium sulfate 80%, hydroxyapatite 18.5%, sodium hypophosphite 1.5%; 2.5ml of silver nitrate aqueous solution with a concentration of 100mmol / L.

[0058] Take by weighing 4g calcium sulfate (calcium sulfate dihydrate 5%), 0.925g hydroxyapatite and 0.075g sodium hypophosphite at room temperature, mix homogeneously; Powder is added to 2.5ml concentration and is the silver nitrate aqueous solution of 100mmol / L, Mix and stir for 1.5 minutes, and the injectable time is about 6.5 minutes.

[0059] The bone cement was cured in an environment of 37°C and 100% relative humidity, and the compressive strength test was performed on the bone cement sample cured for 7 days. The compressive strength test sample was cylindrical (Φ6mm×12mm), and the compressive strength The average value is 10.24Mpa (as attached figure 2 -C shown).

[0060] The bone cement is made into discs (Φ6mm×3mm), and antibacterial experiments are carried out on it. It can be seen that the antibacterial bone c...

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Abstract

The invention relates to injectable antibacterial bone cement. The injectable antibacterial bone cement is composed of powder and liquid, the powder is prepared from, by mass, 70%-90% of calcium sulfate, 8%-29% of apatite and 1%-2% of sodium hypophosphite, the liquid adopts a silver nitrate aqueous solution with the concentration ranging from 10 mmol / L to 500 mmol / L, and the mass ratio of the powder to the liquid is 1.5-2.5 to 1. A soluble silver salt solution is adopted to serve as the liquid, the calcium sulfate, the apatite and the sodium hypophosphite serve as the powder, the sodium hypophosphite is utilized to serve as a reducing agent, after the powder and the liquid are mixed to be uniform, in-situ reduction is conducted on silver ions in silver nitrate, silver and silver oxide are formed and evenly dispersed in the bone cement, novel injectable antibacterial bone cement is prepared, and the problem that due to the fact that the silver or the silver oxide is directly added into the bone cement, the silver element distribution is uneven is solved. The compressive strength is 9.5 MPa or above, and the injectable antibacterial bone cement is a novel antibacterial bone repair material with excellent performance.

Description

technical field [0001] The invention relates to an injectable antibacterial bone cement for bone tissue repair, which is mainly used in the fields of biomedical materials and the like. Background technique [0002] Artificial bone repair is an ideal method for the treatment of bone defects. As a traditional bone repair material, calcium sulfate has a good application prospect in bone repair because of its good biocompatibility and osteoconductivity. Since Dressman first used calcium sulfate to successfully heal bone defects in 1892, calcium sulfate bone repair materials have gradually developed. In 1996, Wright Company of the United States developed surgical grade calcium sulfate bone cement. And passed the US FDA and European certification; recently produced a new generation of injectable bone graft material MIIG bone cement, which not only has clinical curative effect, but also has more accurate and stable biological properties, and provides an effective way for minimall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/50A61L27/12A61L27/02
CPCA61L27/025A61L27/12A61L27/50A61L27/54A61L2300/104A61L2300/404
Inventor 李朝阳崔永顺吕维加
Owner 山东明德生物医学工程有限公司
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