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A kind of Bougainvillea polysaccharide tablet with hypoglycemic health care function and preparation method thereof

A technology of sorghum polysaccharide and tablet, which is applied in the field of sorghum polysaccharide tablet and preparation thereof, can solve the problem of not involving drugs or health products, and achieve the effects of accurate dosage, mild drying conditions, and not easy to absorb moisture.

Active Publication Date: 2019-01-15
迪芬娜健康产业(深圳)集团有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] CN103070880B discloses that Bougainvillea polysaccharide has hypoglycemic effect and its application in the preparation of drugs for treating diabetes, but it does not involve the production of related drugs or health products
Based on the fact that there is no health food made of bougainvillea as raw material in the market, so bougainvillea polysaccharide tablets have broad development prospects and great significance as a functional food for diabetes health care

Method used

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  • A kind of Bougainvillea polysaccharide tablet with hypoglycemic health care function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: the preparation of Bougainvillea polysaccharide tablet

[0034] Tablet specification: 0.3g / tablet, the preparation quantity is 10000 tablets;

[0035] Raw material components: Bougainvillea polysaccharide dry cream powder 150g, starch 90g, microcrystalline cellulose 45g, internal cross-linked PVP 6g, external cross-linked PVP 6g, magnesium stearate 2.4g, 30% ethanol 46.6mL.

[0036] The preparation method is as follows:

[0037] Step 1: Preparation of Bougainvillea polysaccharide dry cream powder:

[0038] 1) Cut the fresh medicinal materials of the above-ground part of the dried bougainvillea into small pieces about 2cm long, clean them and set aside;

[0039] 2) Decoct and filter according to the amount of medicinal materials: water = 1:10, decoct for 2 hours each time, repeat twice, and combine the filtrate;

[0040] 3) Concentrate the filtrate obtained by combining the above steps to an extract with a relative density of 1.1 at a temperature of 60°C...

Embodiment 2

[0047] Embodiment 2: Phenol-sulfuric acid method is used to measure the polysaccharide content of Bougainvillea

[0048] 1) Preparation of sample solution: randomly select 3 pieces of Bougainvillea polysaccharide tablets, weigh them respectively, dissolve them in distilled water, and centrifuge to remove insoluble impurities. , and then take 1mL of the mother solution into a 25mL volumetric flask, dilute to the mark, and shake well to obtain the sample solution;

[0049] 2) Absorbance measurement: Accurately pipette 1mL of sample solution into a test tube, add 1.0mL of 6% phenol and 5.0mL of 98% sulfuric acid in sequence, mix well, cap the tube, let it stand for 30min, and then immerse in a cold water bath After cooling, take out the test tube after the water bath is over, measure the absorbance at a wavelength of 490nm, and obtain the absorbance value of the sample;

[0050] 3) Standard curve: Accurately pipette 1 mL each of glucose standard solutions with concentrations of ...

Embodiment 3

[0055] Example 3: Hypoglycemic Pharmacological Study of Bougainvillea Polysaccharide Tablets

[0056] Animal experiments were carried out aiming at the hypoglycemic health care function of the Bougainvillea polysaccharide tablet.

[0057] 1) Experiment grouping and processing:

[0058] Take 90 26±2g healthy male mice and feed them adaptively for three days, 70 of them fasted for 8 hours, and received a one-time intraperitoneal injection of streptozotocin (STZ) 150mg / kg; the remaining 20 were injected with the same volume Normal saline, as normal mice. After 72 hours, the fasting blood glucose value was measured, and the blood glucose value was greater than 11.1mmol / L as the standard. 50 mice with successful modeling and 20 normal mice were selected for hypoglycemic experiments.

[0059] The mice that successfully established the model were divided into 5 groups, namely hyperglycemia model group, metformin group, low-dose polysaccharide tablet group, medium-dose polysaccharid...

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Abstract

The invention discloses an acanthopanax trifoliatus polysaccharide tablet with blood sugar-reducing and health-care functions, which takes acanthopanax trifoliatus polysaccharide dry extract powder as an active ingredient and comprises the following raw ingredients in parts by weight: 50 parts of acanthopanax trifoliatus polysaccharide dry extract powder, 30 parts of starch, 15 parts of microcrystalline cellulose, 2 parts of internally-added crosslinking PVP, 2 parts of externally-added crosslinking PVP and 0.8 part of magnesium stearate. The invention also discloses a preparation method of the acanthopanax trifoliatus polysaccharide tablet with blood sugar-reducing and health-care functions and a preparation method of acanthopanax trifoliatus polysaccharide dry extract powder. Preparation processes have the advantages of controllable quality, low production cost, accurate dose and the like and are suitable for clinical application of the acanthopanax trifoliatus polysaccharide tablet in health-care products and large-scale industrial production of the acanthopanax trifoliatus polysaccharide tablet. A blood sugar-reducing pharmacological study is also carried out on the acanthopanax trifoliatus polysaccharide tablet through animal experiments, and the result shows that the acanthopanax trifoliatus polysaccharide tablet has an obvious blood sugar-reducing effect, can be used for blood sugar-reducing health-care products and has relatively high safety.

Description

technical field [0001] The invention belongs to the technical field of health food, and relates to a white bougainvillea polysaccharide tablet with hypoglycemic and health-care functions and a preparation method thereof. Background technique [0002] Diabetes has become one of the chronic diseases that seriously threaten human health. Its biochemical characteristics are hyperglycemia, typical clinical manifestations such as polyuria, polydipsia, polyphagia, and weight loss, which are "three more and one less". Diabetes is not a single disease, and its etiology and pathogenesis have not been fully elucidated. Coronary heart disease, nephropathy, retinopathy and neuropathy caused by diabetes are the main causes of death and disability of patients. According to the data of WHO, the incidence of diabetes in the world has been increasing year by year. In 2013, the prevalence of diabetes among adults in my country was about 9.7%, and the total number was about 90 million. Diabet...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K31/715A61K36/254A61P3/10A23L33/00
CPCA23V2002/00A61K9/2009A61K9/2027A61K9/2054A61K9/28A61K31/715A61K36/254A61K2236/331A61K2236/39A61K2236/51A61K2236/53A23V2200/328A23V2250/51A23V2300/10
Inventor 潘育方张旭红杨慧文程轩轩宋凤兰
Owner 迪芬娜健康产业(深圳)集团有限公司
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